Copper Nanoparticles as Growth Promoter, Antioxidant and Anti-Bacterial Agents in Poultry Nutrition: Prospects and Future Implications

Sharif, Muhammad; Rahman, Muhammad Aziz-Ur; Ahmed, Bilal; Abbas, Rao Zahid; Hassan, Faiz‐ul

doi:10.1007/s12011-020-02485-1

Cited by 28 publications

(17 citation statements)

References 96 publications

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“…Also, Pu et al, [46] As in table (6) OTA residue in both liver and muscle, samples of G2 revealed a signi cant increase than all treated groups, while both doses of treatment showed no signi cant difference than G1. It was established that body weight signi cantly increased on feeding CuNP ( [52][53] which signi cantly improved aminopeptidases activity that is vital for protein digestion in muscles [54], ZnONP [55],Cu and Zn NP which resulted in a study [20] in a positive productive effect and muscle tissue by greater accompanied by increased bioavailability of the assessed microelements than inorganic form of mineral supplements. It is proved that feeding on Fe 3 O 4 NPs improved the nal weight and increased bioavailability of trace minerals which enhanced health [56][57][58] The studied haematological and immunological parameters revealed that birds had OTA feeding only (G2) showed signi cant reduction than G1 in TLC, heterophils and monocytes percentages.…”

Section: Discussiionmentioning

confidence: 99%

The efficacy of metal nanocomposite (Fe 3 O 4 /CuO/ZnO) to ameliorate the toxic effects of ochratoxin in broilers

Shap

El-Sherbeny

Masry

2022

Preprint

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Background: The study aimed to investigate the effectiveness of different doses of metal nanocomposite (MNc) (Fe3O4/CuO/ZnO) sub its cytotoxic level in order to overcome or minimize the ochratoxin (OTA) adverse effects in broilers fed on contaminated ration. The study conducted on 120 one - day old chicks which were divided into equal 6 groups; G1: negative control, G2: positive control (fed on OTA 17 ppb), G3 & G4 (fed MNc only with low and high doses respectively). The rest two groups G5 & G6 (treatment groups) were fed on both OTA post induced ochratoxification with low and high doses respectively. Results: Body weight gain and heamatecellular elements in both treated groups increased significantly than control. Serum phagocytic levels were increased-significantly in both treated groups than control groups. Prothrombin time (PT) decreased significantly (P<0.05) in both treated groups than intoxicated control group (G2) but still higher than non-intoxicated control group (G1). Total protein, albumin, globulin, calcium and phosphorus increased significantly in both treated groups than intoxicated control group. Kidney function test showed non significantly improvement in both treated groups than intoxicated control group. Antioxidant study revealed that malondialdehyde (MDA) decreased significantly in treated groups than intoxicated control group. Ochratoxin-residue decreased significantly in treated groups. OTA residues in tested liver and muscle of treated groups showed no-significant difference with control group at the experiment’s end. In conclusion, feeding either low or high doses of MNc to broilers were significantly counteracting the negative impacts of OTA or its resided and increase their body weight gain.

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Section: Discussiionmentioning

confidence: 99%

The efficacy of metal nanocomposite (Fe 3 O 4 /CuO/ZnO) to ameliorate the toxic effects of ochratoxin in broilers

Shap

El-Sherbeny

Masry

2022

Preprint

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“…Copper accretion is correlated chiefly to cattle manure [79] because the confluence of Cu and Zn functions as a complement (anti-bacterial agent in the gut) [80], which boosts microbial activity and also modulates weaning patterns [81]. The application of Cu-rich manure (especially from livestock like pigs) and phosphate-based fertilizers, according to Cheng et al, [82] and Xiong et al [79], may perhaps ultimately lead to Cu accumulation in agricultural soil.…”

Section: Source Apportionment Via Pmfmentioning

confidence: 99%

Human health risk exposure and ecological risk assessment of potentially toxic element pollution in agricultural soils in the district of Frydek Mistek, Czech Republic: a sample location approach

et al. 2021

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Background Human activities considerably contribute to polluting potentially toxic element (PTEs) levels in soils, especially agricultural soils. The consistent introduction of PTEs in the environment and the soil pose health-related risks to humans, flora and fauna. One hundred and fifteen samples were collected in the district of Frydek Mistek (Czech Republic) in a regular grid form. The soil samples were air-dried, and the concentrations of PTEs (i.e. lead, arsenic, chromium, nickel, manganese, cadmium, copper, and zinc) were determined by ICP-OES (inductively coupled plasma optical emission spectrometry). The purpose of this study is to create digitized soil maps that expose the human-related health risks posed by PTEs, estimate pollution indices, ascertain the spatially distributed patterns of PTEs, source apportionment and quantify carcinogenic and non-carcinogenic health risks using the sample location approach. Results The results revealed that the pollution assessment of the soils in the study area using diverse pollution assessment indexes (pollution index, pollution load index, ecological risk and risk index), based on the application of the local background value and the European average value, displayed a range of pollution levels due to differences in the threshold limits from differing geochemical background levels. The principal components analysis and positive matrix factorization, respectively, identified the sources of pollution and the distribution of PTE sources. Mapping the health index and total carcinogenic risk highlighted hotspots of areas within the study area that require immediate remediation. The self-organizing map (SeOM) revealed a diversified colour pattern for the factor scores. A single neuron exhibited a high hotspot in all factor loadings on different blocks of neurons. Children’s CDItotal (Chronic Daily Intake total) values for non-carcinogenic risk and carcinogenic risk were found to be greater than adults’, as were their HQ (hazard quotients) and CR (carcinogenic risk) values. According to the health index of non-carcinogenic risk, 6.1% of the study area sampled posed a potential risk to children rather than adults. Corresponding to the sampled pointwise health risk assessment, 13.05% of the sampled locations are carcinogenic to children. The estimated health risk in the agricultural soil was high, with both carcinogenic and non-carcinogenic risks that could threaten persons living in the study area, particularly children. Conclusion In general, the continuous application of agriculturally related inputs such as phosphate fertilizers and other anthropogenic activities (e.g., steel industry) can increase the level of PTEs in soils. The use of mean, maximum, and minimum values in health risk estimation does not provide a comprehensive picture of a research area’s health state. This study recommends using a sampled pointwise or location health risks assessment approach, which allows researchers to identify high-risk environments that exceeds the recommended threshold as well as areas on the verge of becoming high risk, allowing for rapid remedial action.

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“…In this COVID-19 pandemic, zinc supplementation has been used as an inexpensive adjunct therapy along with potential antiviral drugs to impart additional host resistance against SARS-CoV-2. This would require clinical validation, but using zinc in COVID-19 patients in the current situation would in turn serve as a well-intended trial (Rahman and Idid 2020 ). Using ZnO NPs would thus not only help in inactivation of SARS-CoV-2, but also boost antiviral immunity of the host by increasing the concentration of Zn 2+ in the human body once these ZnO NPs are metabolized and hence can be considered to be used in COVID-19 therapeutics.…”

Section: Use Of Nanotechnology For Treating Covid-19mentioning

confidence: 99%

Use of nanotechnology in combating coronavirus

Gharpure

Ankamwar

2021

3 Biotech

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Recent COVID-19 pandemic situation caused due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected global health as well as economics. There is global attention on prevention, diagnosis as well as treatment of COVID-19 infection which would help in easing the current situation. The use of nanotechnology and nanomedicine has been considered to be promising due to its excellent potential in managing various medical issues such as viruses which is a major threat. Nanoparticles have shown great potential in various biomedical applications and can prove to be of great use in antiviral therapy, especially over other conventional antiviral agents. This review focusses on the pathophysiology of SARS-CoV-2 and the progression of the COVID-19 disease followed by currently available treatments for the same. Use of nanotechnology has been elaborated by exploiting various nanoparticles like metal and metal oxide nanoparticles, carbon-based nanoparticles, quantum dots, polymeric nanoparticles as well as lipid-based nanoparticles along with its mechanism of action against viruses which can prove to be beneficial in COVID-19 therapeutics. However, it needs to be considered that use of these nanotechnology-based approaches in COVID-19 therapeutics only aids the human immunity in fighting the infection. The main function is performed by the immune system in combatting any infection.

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Copper Nanoparticles as Growth Promoter, Antioxidant and Anti-Bacterial Agents in Poultry Nutrition: Prospects and Future Implications

Cited by 28 publications

References 96 publications

The efficacy of metal nanocomposite (Fe 3 O 4 /CuO/ZnO) to ameliorate the toxic effects of ochratoxin in broilers

The efficacy of metal nanocomposite (Fe 3 O 4 /CuO/ZnO) to ameliorate the toxic effects of ochratoxin in broilers

Human health risk exposure and ecological risk assessment of potentially toxic element pollution in agricultural soils in the district of Frydek Mistek, Czech Republic: a sample location approach

Use of nanotechnology in combating coronavirus

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