Background: The study aimed to investigate the effectiveness of different doses of metal nanocomposite (MNc) (Fe3O4/CuO/ZnO) sub its cytotoxic level in order to overcome or minimize the ochratoxin (OTA) adverse effects in broilers fed on contaminated ration. The study conducted on 120 one - day old chicks which were divided into equal 6 groups; G1: negative control, G2: positive control (fed on OTA 17 ppb), G3 & G4 (fed MNc only with low and high doses respectively). The rest two groups G5 & G6 (treatment groups) were fed on both OTA post induced ochratoxification with low and high doses respectively. Results: Body weight gain and heamatecellular elements in both treated groups increased significantly than control. Serum phagocytic levels were increased-significantly in both treated groups than control groups. Prothrombin time (PT) decreased significantly (P<0.05) in both treated groups than intoxicated control group (G2) but still higher than non-intoxicated control group (G1). Total protein, albumin, globulin, calcium and phosphorus increased significantly in both treated groups than intoxicated control group. Kidney function test showed non significantly improvement in both treated groups than intoxicated control group. Antioxidant study revealed that malondialdehyde (MDA) decreased significantly in treated groups than intoxicated control group. Ochratoxin-residue decreased significantly in treated groups. OTA residues in tested liver and muscle of treated groups showed no-significant difference with control group at the experiment’s end. In conclusion, feeding either low or high doses of MNc to broilers were significantly counteracting the negative impacts of OTA or its resided and increase their body weight gain.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.