Copper Nanoparticle/Polymer Composites with Antifungal and Bacteriostatic Properties

Cioffi, Nicola; Torsi, Luisa; Tantillo, Giuseppina; Ghibelli, Lina; Sabbatini, Luigia; Bleve-Zacheo, T.; D'alessio, Maria; Zambonin, P. G.; Traversa, Enrico

doi:10.1021/cm0505244

Cited by 743 publications

(419 citation statements)

References 20 publications

Supporting

Mentioning

389

Contrasting

Unclassified

Order By: Relevance

“…In terms of pH, dissolution was pH 4 ≫ pH 7 > pH 11 for the three CBNPs. At pH 4 [Cu] diss peaked for Figure 5), probably due to precipitation of Cu-containing species like Cu(OH) 2 and CuO. 27 We observed an increase in pH over time in all pH 4 samples (pH 5−6 by Day 90), while pH decreased over time at pH 11 (pH 7−8 by Day 90).…”

Section: ■ Experimental Sectionmentioning

confidence: 74%

“…In contrast to pH 4 and 7, f-Cu 2+ was nondetect at pH 11 both via direct measurements and modeling. Hydrolysis of Cu 2+ occurs at alkaline pH so it exists mostly as Cu(OH) 4 2− , Cu(OH) + , Cu(OH) 2 , and Cu(OH) 3 − . In general, Kocide had higher amounts of dissolved and suspended Cu than nano-Cu and nano-CuO at pH 7 on Cu mass basis.…”

Section: Speciationmentioning

confidence: 99%

“…In this study, however, we also investigated the fate of a commercial Cu(OH) 2 -based product, Kocide 3000 (denoted Kocide). We introduced Kocide, nano-Cu and nano-CuO to a series of aqueous solutions with the goal of investigating the effect of EPS, pH, and IS on (1) stability; and (2) dissolution and speciation over 90 days.…”

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Extracellular Polymeric Substances on the Long-Term Fate, Dissolution, and Speciation of Copper-Based Nanoparticles

Adeleye

Conway

Pérez

et al. 2014

Environ. Sci. Technol.

209

217

View full text Add to dashboard Cite

ABSTRACT:The influence of phytoplankton-derived soluble extracellular polymeric substances (EPS), pH, and ionic strength (IS) on the dissolution, speciation, and stability of nano-CuO, nano-Cu, and Kocide (a micron sized Cu(OH) 2 -based fungicide) was investigated over 90 days. EPS improved the stability of commercial copper-based nanoparticles (CBNPs) in most conditions, in addition to influencing their dissolution. The dissolution rate was pH 4 ≫ pH 7 > pH 11. The presence of EPS correlated with higher dissolved Cu at pH 7 and 11, and lower dissolved Cu at pH 4. More dissolution was observed at higher IS (NaCl) due to complexation with Cl − . Dissolution of nano-CuO at pH 7 increased from 0.93% after 90 days (without EPS) to 2.01% (with 5 mg-C EPS/L) at 10 mM IS. Nano-CuO dissolved even more (2.42%) when IS was increased to 100 mM NaCl (with EPS). The ratio of freeCu 2+ /total dissolved Cu decreased in the presence of EPS, or as pH and/or IS increased. On a Cu mass basis, Kocide had the highest dissolved and suspended Cu at pH 7. However, dissolution of nano-Cu resulted in a higher fraction of free Cu 2+ , which may make nano-Cu more toxic to pelagic organisms. ■ INTRODUCTIONGlobal production of copper-based nanoparticles (CBNPs) was estimated at ∼200 t/yr in 2010, and is increasing. 1 CBNPs have found use in cosmetics, pigments, paints and coatings, electronics, and pesticides. 2−4 These applications may lead to direct exposure of CBNPs to the environment due to normal use, product wear-and-tear, and/or end-of-life disposal. 1 Toxicity of CBNPs and composites to organisms has been demonstrated. 2,5−8 It is therefore important to understand the long-term fate and transformations of these materials in aquatic systems in order to predict exposure to at-risk organisms.Stability and dissolution of engineered nanoparticles (ENPs) depend on ionic strength (IS), pH, and natural organic material (NOM). 9−12 Rapid aggregation of nano-Cu was reported in freshwater by Griffitt et al. 5 The authors also found that less than 0.1% of the nano-Cu dissolved in 48 h in the freshwater media used (pH 8.2). 98% dissolution of nano-Cu was however reported at pH 6 in "uterine-fluid" after a week, 13 demonstrating the importance of pH and media composition on CBNPs' dissolution. Mudunkotuwa and co-workers 14 reported increased dissolution of aged and new CBNPs in the presence of organic acids. Similarly, Worthington et al. 15 showed that the chitosan improved stability and dissolution of nano-Cu. To our knowledge, no studies have previously investigated the effects of naturally occurring NOM such as extracellular polymeric substances (EPS) on the stability and dissolution of CBNPs. EPS are synthesized by microorganisms, which are abundant in natural aquatic systems. EPS are mainly composed of polysaccharides, proteins, nucleic acids, and other polymers; and their composition may vary spatially and temporally even within the same species. 16 EPS may interact with ENPs, thus affecting their fate and transformation. 17 Additional...

show abstract

Section: ■ Experimental Sectionmentioning

confidence: 74%

Section: Speciationmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Extracellular Polymeric Substances on the Long-Term Fate, Dissolution, and Speciation of Copper-Based Nanoparticles

Adeleye

Conway

Pérez

et al. 2014

Environ. Sci. Technol.

209

217

View full text Add to dashboard Cite

show abstract

“…Although only a few studies have reported the antibacterial properties of copper nanoparticles, they show copper nanoparticles have a significant promise as bactericidal agent [16]. However, other nanoparticles, such as platinum, gold, iron oxide, silica and its oxides, and nickel have not shown bactericidal effects in studies with Escherichia coli [15,17,18].…”

Section: Introductionmentioning

confidence: 99%

Strain specificity in antimicrobial activity of silver and copper nanoparticles

Chatterjee²,

et al. 2008

View full text Add to dashboard Cite

“…Indeed, many oral products, including toothpastes, now incorporate powdered (micron-sized) zinc citrate or acetate to control the formation of dental plaque. 110 With respect to nanoparticulate metals, the antimicrobial properties of silver 111 and copper 112 have received the most attention. Both of these have been coated onto or incorporated into various test materials, including the denture material Poly (methyl methacrylate) (PMMA).…”

Section: Nanotechnologymentioning

confidence: 99%