Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose

Abstract

Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2(BDC)2(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 μM and 1803 μM (linear range) with good sensitivity (2500 μA mM−1 cm−2). Our glucose sensor also possesses low limits of detection (0.44 μM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose.

Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing

“…The large surface area and chemical properties of Cu NPs provide high adsorption rates and strong interactions with analytes [ 24 ]. Cu NPs also possess catalytically active sites with enhanced electron transfer rates [ 25 ].…”

Heteroatom-doped graphene as sensing materials: a mini review

“…Sivasankar et al also analyzed human serum samples for glucose by CuNPs/NGO which was prepared by direct carbonization of [Cu 2 (BDC) 2 (DABCO)] MOF. 98 It exhibited a linear concentration range of 1-1803 mM with a detection limit of 0.44 mM. It also showed good sensitivity of 2500 mA mM À1 cm À2 .…”

Carbonization and Preparation of Nitrogen-Doped Porous Carbon Materials from Zn-MOF and Its Applications

“…The morphology of nanoporous carbon can be tuned by optimizing the carbonization method (such as temperature, time, and atmosphere) [1,27,28]. Recently, MOF-derived metal/metal oxide embedded porous carbon materials [29,30] are used in the electrodes for electrochemical sensors [31,32]. But, maintaining the pristine MOF morphology of the resulting porous materials from the carbonization process is a difficult task due to the shrinkage of framework/decomposing organic ligand during carbonization, therefore, a systematic study is necessary [33].…”