Copper(II) complexes with N,N-dimethylbiguanide

Olar, Rodica; Badea, Mihaela; Grecu, Maria Nicoleta; Marinescu, Dana; Lazăr, Veronica; Balotescu, Carmen

doi:10.1007/s10973-007-8767-3

Cited by 17 publications

(12 citation statements)

References 10 publications

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“…Thermal analysis of materials is a very important tool for finding their stability in order to understand the structure [34][35][36], the interactions within components [37][38][39][40] and to know the applicability domains [41,42]. The kinetic studies of the thermal decompositions were usually used for performing lifetime predictions [43,44], for comparative purposes [45,46] or for better understanding of the structural dynamics [47].…”

Section: Investigation Techniquesmentioning

confidence: 99%

Thermal and kinetic study of hexagonal boric acid versus triclinic boric acid in air flow

Rotaru

2016

J Therm Anal Calorim

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Boric acid is a very important inorganic material with diverse uses in optoelectronics, petroleum industry, medicine, agriculture, etc. Recently, it was reported on the modification of the crystallization system of the triclinic boric acid (TBA) to hexagonal boric acid (HBA), when a special obtaining procedure is applied. In this paper, the thermokinetic stability of HBA novel material was comparatively studied with respect to the well-known TBA, in air flow atmosphere. Both HBA and TBA undergo a threestep overall thermal decomposition reaction (dehydration), following similar pathways; from the thermodynamic point of view HBA is more stable-decomposition temperatures and DH are higher in this case compared to those of TBA. The kinetic analysis was performed by means of the isoconversional methods, for each step of dehydration observing different thermokinetic regions. Higher thermal stability for HBA enables it to be employed at higher temperatures instead of TBA, explaining why the triclinic symmetry enhances the formation actually of the pseudohexagonal crystals as crystal habit at the macroscopic scale. Lower thermodynamic and kinetic stability of HBA makes it easier to be activated and thus more instable at the microstructural scale: this is an indirect proof of the TBA presence in the usual surrounding conditions and in the same time raises the probability for HBA molecules to slide onto their crystalline layers due to the lability of hydrogen bonds keeping them and thus increased potential to intercalate with other molecules. The present results open the possibility for promising applications of HBA as a better lubricant for various industries, while in the medical sector superior cleanser, antifungal and antibacterial properties may be foreseen.

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Section: Investigation Techniquesmentioning

confidence: 99%

Thermal and kinetic study of hexagonal boric acid versus triclinic boric acid in air flow

Rotaru

2016

J Therm Anal Calorim

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“…The first weight loss between 50 and 85°C corresponds to the elimination of the ethanolic alcohol, which is in agreement with the results obtained from the IR spectra. Futher weight loss continued with elimination of chloro benzene, resulting from the decomposition of the chlorhexidine (85-170°C), elimination of the coordinated chloride (complex 1), coordinated bromide (complex 2) and ionic and coordinated acetate (complex 3) at 170-400°C and finally removal of the remainder of chlorhexidine between 400 and 800°C [21,22].…”

Section: Physico-chemical Analysesmentioning

confidence: 99%

Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I

et al. 2010

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“…Several studies reported that the copper(II) complexes exhibit antimicrobial activity, especially against Gram-positive bacteria, which seem to be more susceptible than the Gram-negative ones [41,42,43]. In this study, the antimicrobial activity of the obtained compounds was evaluated against Gram-positive ( Enterococcus faecium, Bacillus subtilis, Staphylococcus aureus ) and Gram-negative ( Escherichia coli, Pseudomonas aeruginosa ) bacteria, as well as against fungi ( Candida albicans, Penicillium sp.…”

Section: Resultsmentioning

confidence: 99%

X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives

et al. 2018

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Five new copper(II) acrylate complexes (acr is the acrylate anion: C3H3O2) with imidazole derivatives (2-methylimidazole/2-MeIm, 5-methylimidazole/5-MeIm, 2-ethylimidazole/2-EtIm) of type: cis-[Cu(2-RIm)2(acr)2]·xH2O ((1): R = –CH3, x = 2; (4): R = –CH2–CH3, x = 0), trans-[Cu(2-RIm)2(acr)2] ((2): R = –CH3; (5): R = –CH2–CH3) and trans-[Cu(5-RIm)2(acr)2] ((3): R = –CH3) have been prepared and characterized by elemental analysis, Fourier Transform Infrared spectrometry (FTIR), Electron Paramagnetic Resonance (EPR), electronic reflectance spectroscopy, scanning electron microscopy, and mass spectrometry. The single crystal X-ray diffraction study of complexes (2) and (5) reveals that the copper(II) ion is located on an inversion center and show elongated octahedral geometry completed by two coplanar bidentate acrylates and two unidentate imidazole derivatives displayed in trans positions. For complex (4) the single crystal X-ray diffraction shows that the copper(II) ion is in a distorted octahedral environment which can be easily confused with a trigonal prism completed by two bidentate acrylates and two unidentate imidazole derivatives displayed in cis positions. These results indicate the fact that complexes (4) and (5) are the geometric isomers of the same compound bis(acrylate)-bis(2-ethylimidazole)-copper(II). Complexes (1) and (2), as well as (4) and (5), were produced simultaneously in the reaction of the corresponding copper(II) acrylate with imidazole derivatives in methanol solution. Furthermore, in order to be able to formulate potential applications of the obtained compounds, our next goal was to investigate the in vitro antimicrobial activity of the synthesized complexes against Gram-positive and Gram-negative bacteria, as well as fungal strains, of both clinical and ecological importance (biodeterioration of historical buildings). The trans isomers (2) and (5), followed by (4) have shown the broadest range of antimicrobial activity. In case of (1) and (2) isomers, the trans isomer (2) was significantly more active than cis (1), while the cis isomer (4) proved to be more active than trans (5). Taken together, the biological evaluation results indicate that the trans (2) was the most active complex, demonstrating its potential for the development of novel antimicrobial agents, with potential applications in the biomedical and restoration of architectural monuments fields.

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Copper(II) complexes with N,N-dimethylbiguanide

Cited by 17 publications

References 10 publications

Thermal and kinetic study of hexagonal boric acid versus triclinic boric acid in air flow

Thermal and kinetic study of hexagonal boric acid versus triclinic boric acid in air flow

Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I

X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives

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