Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I

Călinescu, Mirela; Negreanu–Pîrjol, Ticuţa; Georgescu, Rodica; Călinescu, Octavian

doi:10.2478/s11532-010-0028-9

Cited by 19 publications

(22 citation statements)

References 23 publications

(33 reference statements)

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“…In the spectrum of complex 1 , two new bands appeared at 1536 and 1392 cm −1 , which are assigned to ν COO (asy) and ν COO (sym) of the acetate group, respectively. The difference between these two bands (Δν) is 144 cm −1 , which indicate the bidentate behavior of the acetate group . In the spectrum of complex 3 , the appearance of the two new bands at 1487 and 1269 cm −1 with a separation (Δν) of 218 cm −1 indicates that the coordinated nitrate ion is bidentate .…”

Section: Resultsmentioning

confidence: 96%

Synthesis, Characterization, and Catalytic Activity of New Cu(II) Complexes of Schiff Base: Effective Catalysts for Decolorization of Acid Red 37 Dye Solution

Elsherbiny

El‐Ghamry

2015

Int J of Chemical Kinetics

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In this paper, three new Cu(II) Schiff base complexes with three different anions (acetate, chloride, and nitrate) were successfully synthesized and characterized by elemental analysis, mass spectra, molar conductance, FT‐IR, NMR,UV–vis spectroscopy, magnetic moment, ESR, and thermal analysis. The catalytic performances of these complexes in decolorization of azo dye, Acid Red 37, were evaluated. Copper(II) complexes were found to be an efficient catalyst for decolorization of Acid Red 37 in the presence of hydrogen peroxide. The catalytic investigation revealed that the Cu(II) complex with acetate anion (complex 1) performed the highest catalytic activity. The kinetics of the decolorization of AR37 with this catalyst was studied, and the observed rate constant was determined. The effects of different reaction parameters such as catalyst dosage, solution pH, initial concentration of H2O2, dye solution, and reaction temperature on the reaction rate constant were studied. The best reacting conditions should be catalyst dosage = 0.004 g, initial pH 4.0, [H2O2]0 = 0.8 M, and [AR37]0 = 1.16 M at temperature 25°C. Under these conditions, about 99% of AR37 was decolorized within 60 min. The results indicated that the Cu(II) complex with the acetate anion is a promising catalyst for wastewater treatment.

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Section: Resultsmentioning

confidence: 96%

Synthesis, Characterization, and Catalytic Activity of New Cu(II) Complexes of Schiff Base: Effective Catalysts for Decolorization of Acid Red 37 Dye Solution

Elsherbiny

El‐Ghamry

2015

Int J of Chemical Kinetics

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“…This low temperature range of degradation indicates the ionic nature of the acetate. 20 For all three Ni(II) complexes, the last decomposition step (300-680 °C), strongly exothermic, is related to the oxidative degradation of the chlorhexidine ligand. The residue is NiO and the metal content determined is in accordance with the results of the chemical analysis.…”

Section: Thermal Decompositionmentioning

confidence: 97%

“…The experimental mass losses were 10.85 % (calc. 10.57 %) and 20 3, the second decomposition step, with an experimental weight loss of 15.94 %, occurred between 120-210 °C and corresponds to the elimination of two acetate ions (Δ calc = 16.19 %). This low temperature range of degradation indicates the ionic nature of the acetate.…”

Section: Thermal Decompositionmentioning

confidence: 99%

“…They refer to the synthesis and characterization of some complexes of Cu(II), Zn(II) and Ag(I) with chlorhexidine. [20][21][22] The purpose of this study was to establish the products of the interaction of chlorhexidine diacetate with Ni(II), Pd(II) and Cr(III) and the action of the formed metal complexes against some bacteria and fungi. The antioxidant activity of the metal complexes was also evaluated by the photochemiluminescent method.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

Mihalache

Negreanu–Pîrjol

Dumitraşcu

et al. 2018

JSCS

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Six new coordination compounds of Ni(II), Pd(II) and Cr(III) with chlorhexidine, 1,1′-hexamethylenebis[5-(4-chlorophenyl)biguanide], were prepared, characterized and examined for their potential as antimicrobial agents, as well as for their antioxidant activity. The metal complexes correspond to the formulas: [Ni(CHX)]Cl 2 •2H 2 O, [Ni(CHX)]Br 2 •2H 2 O, [Ni(CHX)](CH 3 COO) 2 •C 2 H 5 OH, [Pd(CHX)][PdCl 4 ]•2H 2 O, [Pd(CHX)](CH3COO) 2 and [Cr(CHX)Cl 2 ](CH 3 COO), where CHX = chlorhexidine. Investigations on the in vitro antimicrobial activity of the complexes indicated that all have high activity against the tested bacteria, but are less active against fungi. Among the six complexes, those of Pd(II) showed the highest antibacterial activity, [Pd(CHX)][PdCl 4 ]•2H 2 O being more active against Gram-positive and Gram-negative bacteria than chlorhexidine diacetate. The antioxidant activity of the metal complexes was investigated by photochemiluminescence and the results showed that the palladium(II) complexes have high antioxidant activities.

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“…[31] The non-chalcone bands observed within the ranges 611-630 and 463-473 cm −1 can be assigned to ν (M-O) and ν (M-S) , respectively, confirming the coordination of both oxygen and sulfur atoms to the metal centre. [32,33] The mass spectra of DMATP and its metal complexes are shown in Figure S2. The fragmentation pattern proposed for the mass spectrum of free DMATP is in accordance with m/z of ions produced under electron impact and is shown in Scheme 1.…”

Section: Characterization Of Synthesized Dmatp-metal Complexesmentioning

confidence: 99%

Metal complexes of chalcone analogue: Synthesis, characterization, DNA binding, molecular docking and antimicrobial evaluation

Atlam

El‐Nahass

Bakr

et al. 2017

Applied Organom Chemis

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A novel chalcone, namely 5-(4-(dimethylamino)phenyl)-1-(thiophen-2-yl)penta-2,4-dien-1-one, DMATP, and its complexes with nickel(II), vanadium(III), palladium(II) and platinum(II) metal ions were synthesized and characterized using a set of chemical and spectroscopic tools including elemental analysis, electrical conductance, magnetic susceptibility and spectral techniques. The interactions of the synthesized chalcone and its metal complexes with DNA were studied using steady-state absorption and emission techniques as well as viscosity and electrochemical measurements. The obtained results confirm DNA intercalation. Additionally, theoretical studies were performed for all the investigated compounds using DFT/B3LYP calculations. The optimized geometries are found to be in good agreement with the suggested experimental structures. The bond lengths, bond angles, chemical reactivity, energy components, binding energy and dipole moment were evaluated. Also, theoretical infrared intensities and thermodynamic parameters for all compounds were calculated. Molecular docking calculations show that the Ni(II) complex exhibits the highest DNA binding activity, which agrees well with the experimental results. Finally, the compounds were screened for antimicrobial activity using several microorganisms.

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Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I

Abstract: Investigations on antimicrobial activity in vitro show that all the complexes are active against the tested microorganisms, the complex with chloride being more active against Gram negative bacteria than chlorhexidine diacetate..

Cited by 19 publications

References 23 publications

Synthesis, Characterization, and Catalytic Activity of New Cu(II) Complexes of Schiff Base: Effective Catalysts for Decolorization of Acid Red 37 Dye Solution

Synthesis, Characterization, and Catalytic Activity of New Cu(II) Complexes of Schiff Base: Effective Catalysts for Decolorization of Acid Red 37 Dye Solution

Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

Metal complexes of chalcone analogue: Synthesis, characterization, DNA binding, molecular docking and antimicrobial evaluation

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