Copolymer Involving 2-Hydroxyethyl Methacrylate and 2-Chloroquinyl Methacrylate: Synthesis, Characterization and In Vitro 2-Hydroxychloroquine Delivery Application

Aljubailah, Abeer; Alharbi, Wafa Nazzal Odis; Haidyrah, Ahmed S.; AlGarni, Tahani Saad; Saeed, Waseem Sharaf; Semlali, Abdelhabib; Alqahtani, Saad Mohammed; Al-Owais, Ahmad Abdulaziz; Karami, Abdulnasser Mahmoud; Aouak, Taı̈eb

doi:10.3390/polym13234072

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…The swelling capacity of any polymer used as carrier is an essential condition for performing the dynamic of a drug released from a drug carrier system. According to different investigators, this property is affected by different parameters such as the crosslink degree of the polymer [ 29 , 30 ], temperature [ 31 , 32 ] and pH medium in which the drug is released [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Poly(vinyl Acetate-co-2-hydroxyethyl Methacrylate) and In Vitro Application as Contact Lens for Acyclovir Delivery

Alqahtani

Khulaifi

Alassaf

et al. 2023

IJMS

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A series of poly(vinyl acetate-co-2-hydroxyethylmethacrylate)/acyclovir drug carrier systems (HEMAVAC) containing different acyclovir contents was prepared through bulk free radical polymerization of 2-hydroxyethyl methacrylate with vinyl acetate (VAc) in presence of acyclovir (ACVR) as the drug using a LED lamp in presence of camphorquinone as the photoinitiator. The structure of the drug carrier system was confirmed by FTIR and 1HNMR analysis, and the uniform dispersion of the drug particles in the carrier was proved by DSC and XRD analysis. The study of the physico-chemical properties of the prepared materials, such as the transparency, swelling capacity, wettability and optical refraction, was carried out by UV–visible analysis, a swelling test and measurement of the contact angle and the refractive index, respectively. The elastic modulus and the yield strength of the wet prepared materials were examined by dynamic mechanical analysis. The cytotoxicity of the prepared materials and cell adhesion on these systems were studied by LDH assay and the MTT test, respectively. The results obtained were comparable to those of standard lenses with a transparency of 76.90–89.51%, a swelling capacity of 42.23–81.80% by weight, a wettability of 75.95–89.04 o, a refractive index of 1.4301–1.4526 and a modulus of elasticity of 0.67–1.50 MPa, depending on the ACVR content. It was also shown that these materials exhibit no significant cytotoxicity; on the other hand, they show significant cell adhesion. The in vitro dynamic release of ACVR in water revealed that the HEMAVAC drug carrier can consistently deliver uniformly adequate amounts of ACVR (5.04–36 wt%) over a long period (7 days) in two steps. It was also found that the solubility of ACVR obtained from the release process was improved by 1.4 times that obtained by direct solubility of the drug in powder form at the same temperature.

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Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Poly(vinyl Acetate-co-2-hydroxyethyl Methacrylate) and In Vitro Application as Contact Lens for Acyclovir Delivery

Alqahtani

Khulaifi

Alassaf

et al. 2023

IJMS

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Mevacor/Poly(vinyl acetate/2-hydroxyethyl methacrylate) as Solid Solution: Preparation, Solubility Enhancement and Drug Delivery

Alassaf,

Alqahtani,

Al Khulaifi

et al. 2023

Polymers

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Mevacor/Poly(vinyl acetate-co-2-hydroxyethyl methacrylate) drug carrier systems (MVR/VAC-HEMA) containing different Mevacor (MVR) contents were prepared in one pot by free radical copolymerization of vinyl acetate with 2-hydroxyethyl methacrylate using an LED lamp light in the presence of camphorquinone as a photoinitiator and Mevacor as a drug filler. The prepared material was characterized by FTIR, 1H NMR, DSC, SEM and XRD methods. Different parameters influencing the efficiency in the Mecvacor-water solubility and the drug delivery of this system, such as the swelling capacity of the carrier, the amount of Mevacor loaded and the pH medium have been widely investigated. The results obtained revealed that the Mevacor particles were uniformly dispersed in their molecular state in the copolymer matrix forming a solid solution; the cell toxicity of the virgin poly(vinyl acetate-co-2-hydroxy ethyl methacrylate) (VAC-HEMA) and MVR/VAC-HEMA drug carrier system exhibited no significant effect on their viability when between 0.25 and 2.00 wt% was loaded in these materials; the average swelling capacity of VAC-HEMA material in water was found to be 45.16 wt%, which was practically unaffected by the pH medium and the solubility of MVR deduced from the release process reached more than 22 and 37 times that of the powder dissolved directly in pH 1 and 7 media, respectively. The in vitro MVR release kinetic study revealed that the MVR/VAC-HEMA system containing 0.5 wt% MVR exhibited the best performance in the short gastrointestinal transit (GITT), while that containing 2.0 wt% is for the long transit as they were able to considerably reduce the minimum release of this drug in the stomach (pH1).

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Copolymer Involving 2-Hydroxyethyl Methacrylate and 2-Chloroquinyl Methacrylate: Synthesis, Characterization and In Vitro 2-Hydroxychloroquine Delivery Application

Cited by 2 publications

References 54 publications

Preparation and Characterization of Poly(vinyl Acetate-co-2-hydroxyethyl Methacrylate) and In Vitro Application as Contact Lens for Acyclovir Delivery

Preparation and Characterization of Poly(vinyl Acetate-co-2-hydroxyethyl Methacrylate) and In Vitro Application as Contact Lens for Acyclovir Delivery

Mevacor/Poly(vinyl acetate/2-hydroxyethyl methacrylate) as Solid Solution: Preparation, Solubility Enhancement and Drug Delivery

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