“…Thus there is a reasonably good correlation between the occurrence of withdrawal excitability as indicated in the present experiments and the published results of other workers, for both animal and man. Withdrawal phenomena or CNS tolerance have been reported to occur in laboratory animals after administration of barbiturates (Essig & Flanary, 1959;Ebert, Yim & Miya, 1964;Jaffe & Sharpless, 1965;Leonard, 1968), ethanol (Le Blanc, Kalant, Gibbins & Berman, 1969Ratcliffe, 1972), meprobamate (Kato, 1961) and chlorpromazine (Boyd, 1960) and in man after withdrawal of chlordiazepoxide (Hollister, Motzenbecker & Degan, 1961), methyprylon (Berger, 1961), meprobamate (Essig, 1964), nitrazepam (Oswald & Priest, 1965) and diazepam (Isbell & Chruschiel, 1970). However, no evidence was found in our experiments for a withdrawal excitability following methyprylon or diazepam administration.…”