Convulsive and Sham Rage Behaviors in Decorticate Dogs During Barbiturate Withdrawal

Essig, Carl F.

doi:10.1001/archneur.1962.04210050107012

Cited by 8 publications

(1 citation statement)

References 5 publications

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“…The neocortex plays very little part in the genesis of the barbiturate withdrawal seizure (Essig, 1962;Sharpless & Jaffe, 1966) and it has been concluded that the seizure arises subcortically (Essig & Flanary, 1961). A more specific effect than mere neuronal rebound hyperexcitability (Wikler, Fraser & others, 1955 ;Jaffe & Sharpless, 1965) is therefore likely and many general theories of drug dependence involving putative central synaptic transmitters have been proposed (Crossland, 1957 ;Collier, 1966).…”

Section: Discussionmentioning

confidence: 99%

The effects of drugs on barbiturate withdrawal convulsions in the rat

Norton

1970

Journal of Pharmacy and Pharmacology

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The effects of drugs on barbitone withdrawal convulsions in rats have been examined. Morphine and rnebanazine had no effect on audiogenically induced barbiturate withdrawal seizures. Alcohol, although suppressing the seizures, did not maintain drug dependence. Chlorpromazine prolonged the recovery period after the induction of the convulsions. Meprobamate, chlordiazepoxide and primidone substituted for the barbiturate and maintained drug dependence. 5-HydroxytryptamineY when administered intraventricularly, tryptophan, a-methyl-p-tyrosine and ethosuximide reduced the severity of the withdrawal seizures. Reserpine and p-chlorophenylalanine greatly increased the severity of the seizures. Anxiolytic sedatives substituted for barbitone in dependent animals, other drugs studied affected barbiturate withdrawal convulsions in a way similar to other convulsive processes.

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Section: Discussionmentioning

confidence: 99%