Controversy about the protective role of volume in the frontal sinus after severe head trauma: larger sinus equates with higher risk of death

Çeliker, Metin; Kanat, Ayhan; Özdemır, Adnan; Çeliker, Fatma Beyazal; Kazdal, Hızır; Özdemi̇r, Bülent; Batçık, Osman Ersegun; Özdemir, Doğukan

doi:10.1016/j.bjoms.2019.12.008

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Second, the sample size may not be adequate. A low sample size of a study may restrict the generalizability of the results [31]. In studies, the calculation of sample size is an important issue [32].…”

Section: Discussionmentioning

confidence: 99%

From Nose to Lumbar Spinal Cord – Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf’s Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome

Yolaş¹,

Kanat²,

Zeynal³

et al. 2023

Neuroendocrinology

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Introduction: Olfaction and its relation to human health is an area of growing interest. Although olfaction disorders have been considered a part of Kallmann Syndrome, the role of olfactory dysfunction on spermatogenesis has not been studied yet. We studied if olfactory bulbectomy causes dysfunction in spermatogenesis as a result of Onuf’s nucleus damage. Methods: Twenty-eight male rats were divided into three groups: six as the control (G-1; n=6), six as the only frontal burr-hole applied animals SHAM (G-1I; n=6), and 16 as the study group (G-III; n=16) in which OBX was performed. The animals were followed for two months. After the decapitation of the animals, olfactory bulb (OB) volumes (mm3), the neuron density of the Onuf nucleus (n/mm3), and sperm density (n/mm3) were estimated stereologically, and analyzed. Results: Olfactory bulb volumes (mm3), degenerated neuron density of Onuf's nucleus (n/mm3), and sperm numbers of control, SHAM, and study groups were estimated as: 4±0.5; 6±2 and 103.245±10.841 in G-I; 3.5±0.7; 14±4 and 96.891±9.569 in G-II and 1.3±0.3; 91±17 and 73.561±6.324 in GIII. The statistical results of degenerated neuron density of Onuf's nucleus and sperm numbers between groups are as p<0.005 for GI/GII; p<0.0005 for GII/GIII and p<0.00001 for G-I/G-III. Discussion/Conclusion: This study first time indicates that Onuf's nucleus degeneration secondary to OBX seems to be responsible for reduced sperm numbers.

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Section: Discussionmentioning

confidence: 99%

From Nose to Lumbar Spinal Cord – Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf’s Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome

Yolaş¹,

Kanat²,

Zeynal³

et al. 2023

Neuroendocrinology

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“…With technological advancements in CT, growing evidence suggests the critical role of paranasal sinuses in craniofacial growth and orthodontic treatment [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. In the present study, the three-dimensional size and volume of the frontal sinus were measured using CT images taken before orthodontic treatment in female adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Benington et al [ 21 ] demonstrated that the group with the largest sinus size was the open bite group, which might be attributed to the reduced transmission of occlusal forces along the nasal pillars because of the lack of contact between the maxillary and mandibular incisors, and weaker muscles associated with the hyperdivergent morphology. Furthermore, recently, Celiker et al [ 11 ] investigated the relationship between the size of the frontal sinus and mortality in patients with cranial trauma, and suggested that the larger the sinus, the greater the risk of death resulting from trauma to the head. Our results showed very weak correlation between the three-dimensional size and volume of the frontal sinus and overbite, except a significant, but weak, negative correlation between the sinus height and overbite after the treatment in patients with skeletal Class II malocclusion.…”

Section: Discussionmentioning

confidence: 99%

Volumetric Assessment of the Frontal Sinus in Female Adolescents and Its Relationship with Craniofacial Morphology and Orthodontic Treatment: A Pilot Study

Sawada¹,

Yamada²,

Higashino

et al. 2022

IJERPH

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The present study aimed to evaluate the correlation between frontal sinus morphology and craniofacial morphology, and to investigate the effects of orthodontic treatment on the development of the frontal sinus in female adolescents (mean age: 13.9 ± 1.3 years). In total, 53 patients were recruited and underwent cephalography and computed tomography before and after orthodontic treatment. Of these patients, most had a bilaterally symmetrical fan-shaped frontal sinus without any fusion. The average size and volume of the frontal sinus before orthodontic treatment were 45.8 ± 12.3 mm in breadth, 29.8 ± 7.3 mm in height, 22.7 ± 5.1 mm in depth, and 5151.6 ± 2711.4 mm2 in volume. Sinus volume in patients with skeletal Class III malocclusion tended to be larger than that in patients with skeletal Class I and II malocclusion. Upon comparison with the pretreatment measurements, the sizes and volumes of the frontal sinus were significantly larger following orthodontic treatment, regardless of the skeletal pattern; however, since these changes were small, the increases in the size and volume of the frontal sinus may have been caused by pubertal growth and not orthodontic treatment. The clinical relevance of the frontal sinus remains controversial.

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“…The scientific principles are an important issue in current clinical practice (39), (40). The importance of observational experimental studies lies in the identification of changes and in providing impetus to future research (41).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Important Finding for COVID-19 Pandemic: Hydrocephalus-producing effect of Vaporized Alcohol Disinfectant

Kanat

Aydın

Şahin

et al. 2022

J Neurol Surg A Cent Eur Neurosurg

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BACKGROUND: Alcohol exposure may cause hydrocephalus. In this study, the effect of vaporized nasal alcohol exposure on the choroid plexus, ependymal cells, and developing hydrocephalus was investigated. METHODS: 24 males (∼380g) Wistar rats were used in this study. Animals were divided into three groups, as the control, SHAM and study groups. Then, the study group was again divided into two groups as exposed to light or heavy dose alcohol. The choroid plexuses and intraventricular ependymal cells and ventricles volumes were assessed and compared. RESULTS: Degenerated epithelial cells density 22±5 /mm3 in the control group, 56±11 /mm3 in the SHAM group, 175±37 /mm3 in the light, and 356±85 /mm3 in the heavy alcohol exposure group. Evan's index was less than <34% in the control, larger than >36% in the SHAM, larger than >40% in the group which was exposed to light alcohol (light alcohol group), larger than >50% in heavy alcohol (heavy alcohol group) exposed. CONCLUSIONS: It was found that alcohol exposure causes choroid plexus and ependymal cell degeneration with ciliopathy and the enlarged lateral ventricles or hydrocephalus. In the COVID-19 Pandemic Era, our findings are functionally important; alcohol has often been used for hygiene and prevention of transmission of COVID-19 pandemic.

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Controversy about the protective role of volume in the frontal sinus after severe head trauma: larger sinus equates with higher risk of death

Cited by 10 publications

References 25 publications

From Nose to Lumbar Spinal Cord – Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf’s Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome

From Nose to Lumbar Spinal Cord – Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf’s Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome

Volumetric Assessment of the Frontal Sinus in Female Adolescents and Its Relationship with Craniofacial Morphology and Orthodontic Treatment: A Pilot Study

Important Finding for COVID-19 Pandemic: Hydrocephalus-producing effect of Vaporized Alcohol Disinfectant

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