Controlling nucleation and growth of nano-CaCO3 via CO2 sequestration by a calcium alkoxide solution to produce nanocomposites for drug delivery applications

Palmqvist, N.G. Martin; Nédélec, Jean-Marie; Seisenbaeva, Gulaim A.; Kessler, Vadim G.

doi:10.1016/j.actbio.2017.05.006

Cited by 20 publications

(8 citation statements)

References 54 publications

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“…The nanosized channels on the shells can facilitate the exchange of the substrates between the inside and outside of the chambers. The biomineralized nanogels will find applications in biocatalysis, drug/protein delivery, and cell harvesting …”

Section: Resultssupporting

confidence: 59%

“…The biomineralized nanogels will find applications in biocatalysis, drug/protein delivery,a nd cell harvesting. [33,34] Experimental Section Synthesis of P(NIPAM-co-PDSMA) P(NIPAM-co-PDSMA) was synthesized through RAFT polymerization. NIPAM (1.00 g, 8.85 mmol), PDSMA monomer (45.0 mg, 0.177 mmol), S-1-dodecyl-S'-(a,a'-dimethyl-a''-acetic acid) trithiocarbonate (10.74 mg, 0.02950 mmol), and azobisisobutyronitrile (AIBN;0 .97 mg, 0.0059 mmol) were dissolved in anhydrous DMF (4 mL) in a1 0mLS chlenk flask.…”

Section: Resultsmentioning

confidence: 99%

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Biomimetic Mineralization of Protein Nanogels for Enzyme Protection

Liu

et al. 2019

Chemistry A European J

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Protein nanogelsh ave found aw idev ariety of applications, ranging from biocatalysis to drug/protein delivery. However,i np ractical applications, proteinsi nn anogelsm ay suffer from enzymic hydrolysis and denaturation. Inspired by the structure and functionalities of the fowl eggshells, biomimetic mineralization of protein nanogels was studied in this research. Protein nanogelsw ith embedded porcine pancreas lipase (PPL) in the cross-linked nanostructures were synthesized throught he thiol-disulfide reactionb etween thiol-functionalized PPL and poly(N-isopropylacrylamide) with pendant pyridyl disulfide groups.T he nanogels were further reacted with reducedb ovine serum albumin( BSA) and BSAmolecules were coated on the nanogels. Mineraliza-tion of BSA leads to the synthesis of biomineralized shells on the nanogels. With the growth of CaCO 3 on the shells, the nanogels aggregate into suprastructures. Thermogravimetric analysis, XRD, dynamic light scattering, and TEM were employed to study the mechanismo ft he biomineralization process and analyze the structureso ft he mineralized nanogels. The biomineralized shells can effectively protect the PPL molecules from hydrolysis by trypsin;m eanwhile, the nanosized channels on the mineralized shells allow the transport of small-molecule substrates across the shells.B ioactivity measurements indicatet hat PPL in the nanogels maintains more than 80 %b ioactivity after biomineralization.[a] Q.

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Section: Resultssupporting

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Biomimetic Mineralization of Protein Nanogels for Enzyme Protection

Liu

et al. 2019

Chemistry A European J

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“…WBS and EBS could also be employed as scaffolds for drug delivery and tissue engineering. Palmqvist et al [103] controlled nucleation and growth of produced nano by the sol-gel process to generate nanocomposites for drug delivery purposes by CO 2 seques-tration by a calcium alkoxide solution. In neutral aqueous conditions, the composite particles are stable but are readily dissolved at pH = 7.40 in an acid media or also in phosphate-buffered saline (PBS), releasing the hydrophobic organic part in the form of a reasonably stable colloid solution.…”

Section: Calcium Composite Drug Carriersmentioning

confidence: 99%

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

Azadani

Sabbagh²,

Salehi

et al. 2021

jcc

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“…Since water is an inducing factor for the crystallization of ACC, [ 105 ] so one strategy is to use organic solvents such as ethanol or methanol instead of water as the solvent. [ 106 ] For example, Dong et al. [ 107 ] synthesized CaCO 3 nanoparticles modified with PEG with an average diameter of around 100 nm by a gas diffusion reaction using ethanol as the solvent.…”

Section: Calcium Carbonate‐based Nanocarriersmentioning

confidence: 99%

Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery

Cai

Zhu

2020

Adv Materials Inter

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drugs are not loaded into the carriers and are taken into the body of the patient by oral or injection. As a result, the traditional drug delivery system without drug carriers has some problems, for example, the drug is rapidly released (burst drug release) in a short period of time after being taken into the patient's body, leading to high drug concentration in vivo which is usually harmful to the patient. In addition, the burst drug release at early stage of drug administration will lead to rapid decrease in drug concentration in vivo in a short time, which is lower than that required for effective treatment, that is, the time that the drug can effectively treat the disease is significantly shortened, as shown in

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Controlling nucleation and growth of nano-CaCO3 via CO2 sequestration by a calcium alkoxide solution to produce nanocomposites for drug delivery applications

Cited by 20 publications

References 54 publications

Biomimetic Mineralization of Protein Nanogels for Enzyme Protection

Biomimetic Mineralization of Protein Nanogels for Enzyme Protection

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery

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