Controlled release of gentamicin from calcium phosphate—poly(lactic acid-co-glycolic acid) composite bone cement

Schnieders, Julia; Gbureck, Uwe; Thulĺ, R.; Kissel, Thomas

doi:10.1016/j.biomaterials.2006.03.032

Cited by 148 publications

(96 citation statements)

References 33 publications

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“…Therefore it may be necessary to extend the period in which the antibiotic is released from the implant reservoir. To achieve this, polymeric microspheres may be used to encapsulate the antibiotic, which may be incorporated into the cement [42] and [43]. Cement cylinders without gentamicin were shown to exhibit some ability to inhibit the growth of S. aureus but had limited effect against S. epidermidis ( Fig.…”

Section: 1mentioning

confidence: 99%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calciumphosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (b28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.

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Section: 1mentioning

confidence: 99%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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“…However, PMMA is not a resorbable polymer and must be removed in a second surgical procedure (Vallet-Regí et al 2007;Shi et al 2009). In this context, it should be pointed out that most previous work on loading biomaterials with antibiotics for orthopaedic applications has been carried out on bone-filler materials and bone cements (Takechi et al 1998;Armstrong et al 2002;Diez-Peñ a et al 2002;Gbureck et al 2002;Joseph et al 2003;Hanssen 2004;Joosten et al 2004;Webb et al 2005;Schnieders et al 2006;Krasko et al 2007;Zilberman & Elsner 2008). In one of the first attempts to develop multifunctional re-absorbable implants, Queiroz et al (2001) prepared sodium ampicillin which was adsorbed onto HA and glass-reinforced HA composites as a potential pharmaceutical formulation for periodontitis.…”

Section: Controlled Release Of Antibioticsmentioning

confidence: 99%

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

Mouriño

Boccaccını

2009

J. R. Soc. Interface.

471

298

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This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs. Typical drugs considered include gentamicin and other antibiotics generally used to combat osteomyelitis, as well as anti-inflammatory drugs and bisphosphonates, but delivery of growth factors is not covered in this review. In each case reviewed, special attention has been given to the technology used for controlling the release of the loaded drugs. The possibility of designing multifunctional three-dimensional bone TE scaffolds for the emerging field of bone TE therapeutics is discussed. A detailed summary of drugs included in three-dimensional scaffolds and the several approaches developed to combine bioceramics with various polymeric biomaterials in composites for drug-delivery systems is included. The main results presented in the literature are discussed and the remaining challenges in the field are summarized with suggestions for future research directions.

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“…Besides, incorporation of microspheres into scaffolds can abolish the initial burst by a combination of pore diffusion and polymer erosion. 33,34 Bioadhesive materials The objective of using mucoadhesive or bioadhesive controlled drug delivery system is to prolong their residence at a specific site of delivery, thus facilitating the drug absorption process. For mucoadhesive agent, first-pass metabolism in the liver and presystemic elimination in the GI tract is avoided as the mucosa is well supplied with both vascular and lymphatic drainage.…”

Section: Biodegradable Materialsmentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Controlled release of gentamicin from calcium phosphate—poly(lactic acid-co-glycolic acid) composite bone cement

Cited by 148 publications

References 33 publications

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

Recent advances in materials for extended-release antibiotic delivery system

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