Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox, Sophie C.; Jamshidi, Parastoo; Eisenstein, Neil; Webber, Mark A.; Hassanin, Hany; Attallah, Moataz M.; Shepherd, Duncan E.T.; Addison, Owen; Grover, Liam M.

doi:10.1016/j.msec.2016.04.006

Cited by 75 publications

(63 citation statements)

References 40 publications

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“…Lifecycle cost, sustainability, supply chain and production costs have been less focused on. General aspects of AM (Bikas et al, 2015;Bogers et al, 2016;Brans, 2013;Cardaropoli et al, 2012a;Ferro et al, 2016;Gao et al, 2015;Go & Hart, 2016;Hedrick et al, 2015;Kianian et al, 2016;Lindemann et al, 2015;Mellor et al, 2014;Muita et al, 2015;Nickels, 2016;Rayna & Striukova, 2016;Scholz et al, 2016;Winkless, 2015;Wits et al, 2016;Wong & Hernandez, 2012); industry (Brettel et al, 2016;Gaub, 2015;Fera & Macchiaroli, 2010;Stock & Seliger, 2016); implications of its use (Bogers et al, 2016;Huang et al;Newman et al, 2015;Rayna & Striukova, 2016); example of its application (Caiazzo et al, 2013;Cardaropoli et al, 2012b;Gupta et al, 2016;Huang et al;Uhlmann et al, 2015;Wits et al, 2016); flexibility (Brettel et al, 2016;Cox et al, 2016) and technology selection (Newman et al, 2015) allow us to contextualize AM in an actual production system. There are many papers on mechanical characteristics, microstructures and properties (Brugo et al, 2016;Hinojos et al, 2016;Huynh et al;List et al, 2014;<...>…”

Section: Literature Review Methodsmentioning

confidence: 99%

Cost models of additive manufacturing: A literature review

Costabile¹,

Fera²,

Fruggiero³

et al. 2017

10.5267/j.ijiec

104

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From the past decades, increasing attention has been paid to the quality level of technological and mechanical properties achieved by the Additive Manufacturing (AM); these two elements have achieved a good performance, and it is possible to compare this with the results achieved by traditional technology. Therefore, the AM maturity is high enough to let industries adopt this technology in a more general production framework as the mechanical manufacturing industrial one is. Since the technological and mechanical properties are also beneficial for the materials produced with AM, the primary objective of this paper is to focus more on managerial facets, such as the cost control of a production environment, where these new technologies are present. This paper aims to analyse the existing literature about the cost models developed specifically for AM from an operations management point of view and discusses the strengths and weaknesses of all models.

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Section: Literature Review Methodsmentioning

confidence: 99%

Cost models of additive manufacturing: A literature review

Costabile¹,

Fera²,

Fruggiero³

et al. 2017

10.5267/j.ijiec

104

View full text Add to dashboard Cite

show abstract

“…These techniques have been implemented to produce parts with the desired precision and surface quality [2,11,12] . Selective laser melting (SLM) is one of the additive manufacturing techniques in which a 3D product is built layer-by-layer [13][14][15] . SLM allows more freedom for the Computer Aided Drafting (CAD) designers to enable design and topology optimisation.…”

Section: Take Down Policymentioning

confidence: 99%

Manufacturing of Ti–6Al–4V Micro‐Implantable Parts Using Hybrid Selective Laser Melting and Micro‐Electrical Discharge Machining

Hassanin

Modica²,

El‐Sayed

et al. 2016

Adv Eng Mater

Self Cite

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“…Robocasting has been used to incorporate a range of agents including levofloxacin 13 , quaternary ammonium compounds 14 or silver nanoparticles 15 , in a field again largely aimed at developing bone implants. Selective Laser Melting (SLM) of titanium 16 or cobalt-chromium-molybdenum 17 has been employed by several groups to develop bone implants -adding antimicrobial functionality to these generally requires a post-processing step, likely due to the high temperatures involved in melting metal being deleterious to many antimicrobials. To the best of our knowledge, no antimicrobial materials made using Laser Sintering have been described to date in the academic literature.…”

mentioning

confidence: 99%

Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts

Turner

Wingham

Paterson

et al. 2020

Sci Rep

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Infectious diseases (exacerbated by antimicrobial resistance) cause death, loss of quality of life and economic burden globally. Materials with inherent antimicrobial properties offer the potential to reduce the spread of infection through transfer via surfaces or solutions, or to directly reduce microbial numbers in a host if used as implants. Additive Manufacturing (AM) techniques offer shorter supply chains, faster delivery, mass customisation and reduced unit costs, as well as highly complicated part geometries which are potentially harder to clean and sterilise. Here, we present a new approach to introducing antibacterial properties into AM, using Laser Sintering, by combining antimicrobial and base polymer powders prior to processing. We demonstrate that the mechanical properties of the resultant composite parts are similar to standard polymer parts and reveal the mode of the antibacterial activity. We show that antibacterial activity is modulated by the presence of obstructing compounds in different experimental media, which will inform appropriate use cases. We show that the material is not toxic to mammalian cells. This material could be quickly used for commercial products, and our approach could be adopted more generally to add new functionality to Laser Sintered parts. The global Additive Manufacturing (AM) market has grown by an average of 26.9% annually for the last 30 years, with the overall revenue of the industry currently estimated at $9.8 billion, and aerospace, automotive and healthcare being major sectors 1. Parts are produced in a layer-by-layer manner, directly from a Computer-Aided Design (CAD) file. This layer-by-layer approach provides key benefits through removing the need for tooling and increasing the ease with which complex geometries can be produced. However, despite their clear potential, the range of materials that can be used in AM processes is limited compared to more traditional manufacturing techniques, which in turn has restricted the range of applications in which they can be used. Laser Sintering is an AM technology that produces parts by selectively scanning and melting consecutive cross-sections of polymer powder particles. Areas which have not been scanned remain as loose powder throughout the process, acting to support any overhanging areas, which in turn allows the economic production of highly complex part geometries. This geometric capability makes Laser Sintering highly suited to production of complex, optimised, products and devices, or to the production of products and devices personalised to individuals. However, particularly when considering hand-held and/or medical products, increasing geometric complexity can render them difficult and time-consuming to clean effectively, potentially providing increased chance of spread of bacteria. Incorporation of antibacterial properties into the parts themselves could reduce or eliminate this risk, and is the focus of this work. Many antimicrobial products are currently available to purchase, with a growing global market fo...

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Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cited by 75 publications

References 40 publications

Cost models of additive manufacturing: A literature review

Cost models of additive manufacturing: A literature review

Manufacturing of Ti–6Al–4V Micro‐Implantable Parts Using Hybrid Selective Laser Melting and Micro‐Electrical Discharge Machining

Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts

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