Controlled release of ferulic acid from a hybrid hydrotalcite and its application as an antioxidant for human fibroblasts

Lima, Enrique; Flores, Jose; Cruz, Alejandra Santana; Leyva-Gómez, Gerardo; Krötzsch, Edgar

doi:10.1016/j.micromeso.2013.07.014

Cited by 34 publications

(24 citation statements)

References 41 publications

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“…[22][23][24]25]. LDHs have been specifically used as nanocarriers of AOs, such as carnosine, gallic acid, vanillic acid, and ferulic acid [26,27]. The intercalation between the layers protects the AO from oxidation during storage [22,24], reduces the effects of migration, and shows release behaviour suitable for their use in controlled delivery systems [22].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Thermo-oxidative stabilization of poly(lactic acid) with antioxidant intercalated layered double hydroxides

Amaro

Cicogna

Passaglia

et al. 2016

Polymer Degradation and Stability

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Two antioxidant modified layered double hydroxides (AO-LDHs) were successfully prepared by the intercalation of 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid (IrganoxCOOH) and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) in the layered structure of LDH. It was found that by anchoring the phenolic moieties to the LDH layers the antioxidant power is retained in the case of Trolox, and even amplified in the case of IrganoxCOOH. A small amount of the two AO-LDHs was incorporated into poly(lactic acid), PLA, by solution mixing and melt extrusion. The thermo-oxidative stability of the composites was compared with that of the neat PLA and PLA containing free AOs. SEC analysis indicates that, after a controlled period of ageing, both the AO-LDHs protect the PLA from chain scission. The oxidation induction time (OIT, DSC) at 230 °C shows also the beneficial effects of the presence of the functional filler in the polymer matrix. Further, results from a preliminary migration test suggest that the AO species have a low tendency to migrate away from the AO-LDHs embedded in the polymer matrix thus keeping the AO protected inside the nanofiller layers thereby remaining active for a longer time.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Thermo-oxidative stabilization of poly(lactic acid) with antioxidant intercalated layered double hydroxides

Amaro

Cicogna

Passaglia

et al. 2016

Polymer Degradation and Stability

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“…Ferulic acid has been quantified by many analytical methods, such as high-performance liquid chromatography (HPLC) coupled with photodiode array wavelength detector (PDA) or UV-Vis detector [9][10][11][12][13], UV-Vis spectroscopy [14,15], thin layer chromatography [16], high-performance thin-layer chromatography [17], gas chromatography [18], chemiluminescence [19] and capillary electrophoresis [20]. However, HPLC is considered the most reliable and popular methodology for investigating phenolic acids [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Ferulic Acid in Arabica Coffee Bean (Coffea Arabica L.) Using Solid Phase Extraction–high Performance Liquid Chromatography

et al. 2019

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Objective: The purpose of this research is quantitatively analyzing of ferulic acid in the Arabica coffee bean extract from three samples with different regions (Garut, Pangalengan, Tasikmalaya, West Java Indonesia) using Solid Phase Extraction-High Performance Liquid Chromatography (SPE-HPLC) method which is validated. Methods: The analysis method used reversed phase HPLC with an Enduro C 18 G (250 mm × 4.6 mm) column and detector UV 312 nm, with a mobile phase of methanol and water containing 1% (v/v) of acetic acid (42:58) at a flow rate of 1.0 ml/min and validation method was examined in linearity, Limit of Detection (LOD), Limit of Quantification (LOQ), precision, and accuracy. Results: The results showed that the precision of retention was 8.853 min, correlation coefficient (R) was 0.9996, and the recovery was 96.909%. The quantitative analysis of ferulic acid content in the extract of coffee from thus samples of three different regions were 0.0385%, 0.0169% and 0.0076%, respectively. Conclusion: The analytical method was meet the validation criteria. Ferulic acid levels results from the extraction of the digestion process and pretreatment methods of Solid Phase Extraction (SPE) is 0.0385% from Garut area, 0.0169% from Pangalengan area and 0.0076% from Tasikmalaya area.

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“…FA has been quantified by many analytical methods, such as high-performance liquid chromatography (HPLC) coupled with photodiode array wavelength detector (PDA) or UV-Vis detector (Anselmi et al, 2006;Craparo et al, 2009;Kareparamban et al, 2013;Li et al, 2007;Li et al, 2004;Li, Bi, 2003;Lu et al, 2005;Nadal et al, 2015;Picone et al, 2009;Qi et al, 2007;Wang et al, 2011), liquid chromatography tandem mass spectrometry (Guy et al, 2009;Wang et al, 2013;Zhang et al, 2009), UV-Vis spectroscopy (Lima et al, 2013;Merlin et al, 2012), thin layer chromatography (Mabinya, Mafunga, Brand, 2006), high-performance thin layer chromatography (Hingse, Digole, Annapure, 2014;Srivastava, Singh, Singh Rawat, 2012), gas chromatography (Olthof et al, 2003), chemiluminescence (Shen et al, 2013), capillary electrophoresis (Lima, Duarte, Esteves, 2007), micellar electrokinetic chromatography (Guo et al, 2003), electrochemical analysis (Vilian, Chen, 2014) and paper-based platforms (Tee-Ngam et al, 2013). However, HPLC is considered the most reliable and popular methodology for investigating phenolic acids (Barberousse et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles

Lima

Khalil

Mainardes

2017

Braz. J. Pharm. Sci.

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The development and validation of a simple and efficient method for the quantification of ferulic acid in poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan (CS) by reverse phase high performance liquid chromatography coupled to photodiode array detection was described. For the chromatographic analysis, a reverse phase C-18 column was used, mobile phase consisting of acetonitrile and 0.5% acetic acid (37:63, v/v), isocratically eluted at a flow rate of 1 mL/min. Drug determination was performed at 320 nm. The method was validated in terms of the selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification. The method was linear in the range of 10 to 100 μg/mL (r=0.999) and presented limit of detection and quantification of 102 ng/mL and 310 ng/mL, respectively. The method was precise (intra and inter-day) based on relative standard deviation values (less than 3.20%). The recovery was between 101.06 and 102.10%. Robustness was demonstrated considering change in mobile phase proportion. Specificity assay showed no interference from the components of nanoparticles or from the degradation products derived from acidic and oxidative conditions. The proposed method was suitable to be applied in determining the encapsulation efficiency of ferulic acid in PLGA-CS nanoparticles and can be employed as stability indicating one.Uniterms: Nanoparticles. Ferulic acid/encapsulation efficiency. Ferulic acid/quantification. Stability. High performance liquid chromatography/validation. PLGA-poly(lactide-co-glycolide)/nanoparticles. Chitosan.

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Controlled release of ferulic acid from a hybrid hydrotalcite and its application as an antioxidant for human fibroblasts

Cited by 34 publications

References 41 publications

Thermo-oxidative stabilization of poly(lactic acid) with antioxidant intercalated layered double hydroxides

Thermo-oxidative stabilization of poly(lactic acid) with antioxidant intercalated layered double hydroxides

Analysis of Ferulic Acid in Arabica Coffee Bean (Coffea Arabica L.) Using Solid Phase Extraction–high Performance Liquid Chromatography

A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles

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