Controlled-Release Multiple-Units and Single-Unit Doses a Literature Review

Bechgaard, Helle; Nielsen, G. Hegermann

doi:10.3109/03639047809055639

Cited by 208 publications

(80 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The application of oral sustained release formulations has improved patient compliance due to a lower dosing frequency and a reduced incidence of adverse side effects [5]. Moreover, the production of sustained release multiparticulate dosage forms is advantageous since their transport in the gastro-intestinal tract is independent of gastric emptying and they exhibit a reduced risk of dose accumulation and local irritation when compared to single-unit dosage forms [6].…”

Section: Introductionmentioning

confidence: 99%

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Vervaeck

Saerens

Geest

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Vervaeck

Saerens

Geest

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

“…5 When multiple-unit systems are taken orally, the subunits of these multiple-unit preparations distribute over a large surface area of the gastrointestinal tract. These small particles (<2 mm) act as liquids which leave the stomach within a short period.…”

Section: Features Of Multiparticulate Dosage Formmentioning

confidence: 99%

Multiple Unit Pellet System (Mups Technology) for Development of Modified Release Fast Disintegrating Tablets: A Review

Patel¹,

Patel²,

Joshi³

2017

J. Pharm. Sci. Innov.

View full text Add to dashboard Cite

Oral drug delivery system becomes challenging when the drug product needs to be delivered in modified release pattern in elderly patients, especially since it is difficult to swallow for them. Multiparticulates are the choice of dosage form when fast disintegration is desirable without loss of original release profile. Compressed multi-particulate system prepared by using pellets have several pharmacokinetic, pharmacodynamic, commercial and other advantages as mentioned henceforth in this review article. It includes not only different types of modified release pellets that can be compressed into Multiple Unit Pellet System (MUPS) but also factors regulating the compression behavior of pellets including properties of pellets, core material, and compressible excipients. This review also presents detailed explanation on physicochemical properties of pellets and formulation strategies of MUPS.

show abstract

“…As they tend to spread uniformly, avoid the differences in gastric emptying and transit rates, and thereby release the drugs more uniformly throughout the GIT. 1,2 On chronic dosing of a drug multiple unit dosage forms prevents the exposure of organs to higher drug concentrations unlike single unit dosage forms. 3,4 They are more preferred owing to their higher degree of dispersion in GI tract, increased bioavailability, decreased dosing frequency, and reduced risk of toxicity.…”

Section: Introductionmentioning

confidence: 99%

Enteric Delivery of Diclofenac Sodium through Functionally Modified Poly(acrylamide-grafted-Ghatti gum)-based pH-sensitive Hydrogel Beads: Development, Formulation and Evaluation

Moin¹,

Hussain²,

Gowda³

2017

JYP

View full text Add to dashboard Cite

Background: To prepare and characterize modified Poly(acrylamide-grafted-Ghatti gum). To formulate & evaluate using this grafted polymer pH-sensitive hydrogel beads of diclofenac sodium for enteric delivery. Methods: Polyacrylamide was grafted onto ghatti gum with microwave assistance using ceric ammonium nitrate as redox initiator. Optimization of formulation was done by varying the irradiation time, amount of initiator and acrylamide keeping amount of ghatti gum (GG) as constant. The copolymer was characterized using Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), Differential scanning calorimetry (DSC), elemental analysis, viscosity, molecular weight, neutralization equivalent, swelling, biodegradability and acute oral toxicity studies. Results: The copolymer was found to be biodegradable and non-toxic. Further the optimized copolymer was used to generate novel pH sensitive hydrogel. Diclofenac sodium (DS) was loaded into pH sensitive beads by ionotropic gelation technique using AlCl 3 as crosslinking agent. Pulsatile swelling study indicated that the copolymer exhibits considerable pH-sensitive behaviour unlike pure gum. In vitro release studies were performed and it was found to be much less from copolymeric beads than from pure ghatti beads. Furthermore, a maximum of 20 % drug was released from copolymeric beads in pH 1.2-5.5 in first 3 h period, while 80 % was released in pH 6.8-7.4 in 8 hr. Key words: Acrylamide grafted ghatti gum; Biodegradable; Diclofenac sodium; pH-sensitive hydrogel; Controlled-release. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

show abstract

Controlled-Release Multiple-Units and Single-Unit Doses a Literature Review

Cited by 208 publications

References 35 publications

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Multiple Unit Pellet System (Mups Technology) for Development of Modified Release Fast Disintegrating Tablets: A Review

Enteric Delivery of Diclofenac Sodium through Functionally Modified Poly(acrylamide-grafted-Ghatti gum)-based pH-sensitive Hydrogel Beads: Development, Formulation and Evaluation

Contact Info

Product

Resources

About