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lowest saralasin infusion rate. At the higher infusion rates blood pressure decreased continuously to a minimum of 75/55 mm Hg at the end of the infusion period. At that moment the patient felt seriously ill, had a pale complexion, and vomited several times. After the infusion was stopped the blood pressure reached its preinfusion level within 30 min. Plasma renin activity (PRA) was measured at the beginning and the end of each infusion (see table). PRA (,ug'l 3 h) Before After saralasin saralasin Moderate sodium intake 10 6 3 After six days' chlorthalidone 100 mg, day 40 > 125 The findings in this patient show firstly that saralasin infusion may lead to a potentially hazardous initial rise in blood pressure when PRA is low, as has been demonstrated by others,2 and secondly that saralasin infused after severe sodium depletion with chlorthiazide diuretics and vigorously stimulated PRA may cause severe hypotension even at low-dose infusion rates.

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An aqueous jelly and two oleaginous ointments containing less than 3 % boric acid wlv, were applied on the skin of anaesthetized rats. When application was made on the intact skin of the dorsal surface (about 28 cm2) determination of boric acid concentrations in the urine 8 hours later showed no or slight increases above the normal level. When the skin was damaged the ointments caused increased excretion up to 4-8 times that of the excretion found in control animals, while the jelly caused a 34 times increase. When an enclosed skin area of 4.3 cm2 was damaged and treated, and simultaneous recording of boric acid recovery in both the urine and applied preparations (jelly and one ointment) was made 5 hours later, about 98 % boric acid still remained in the ointment, but only 25 % in the jelly. The recoveries in the urine were 1 % and 25 % respectively, indicating slight absorption and rapid excretion in the case of the oleaginous ointment, and high absorption with inadequate excretion when the aqueous jelly was applied.