Multiple Unit Pellet System (Mups Technology) for Development of Modified Release Fast Disintegrating Tablets: A Review

Patel, Nrupa; Patel, Sandipkumar A.; Joshi, Abhijeet

doi:10.7897/2277-4572.06352

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Such drug-layered pellets (multiparticulates) can be placed in hard capsule shells or sachets and are intended to be sprinkled onto a teaspoon or tablespoon of soft food or liquid and swallowed immediately without chewing. The drug substance is contained in many independent units, which makes the formulation very flexible, so that the dose of the drug can be regulated only by the mass of the RSC multiparticulates applied [ 33 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium

Cal

Mikolaszek

Hess³

et al. 2023

Pharmaceuticals

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Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS (multiple-unit pellet system) containing rosuvastatin calcium as a model drug substance was successfully developed. The formulation was prepared by drug layering technique using novel calcium phosphate-based starting pellets (PharSQ® Spheres CM) of three different particle sizes. The study showed that the developed multiparticulates were characterized by uniform distribution of coating layers thickness, as well as fast dissolution rate (more than 85% of rosuvastatin calcium dissolved within 30 min, as required by the relevant USP/NF monograph). Rosuvastatin calcium, like other statins, has a bitter, unpleasant taste. Investigations conducted with an electronic tongue suggested that the developed formulation achieved the desired taste-masking efficiency. The effect was found to be particle size-dependent, improving as the size of the multiparticulates increased.

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Section: Discussionmentioning

confidence: 99%

The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium

Cal

Mikolaszek

Hess³

et al. 2023

Pharmaceuticals

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“…Manufactured pellets demonstrate superior flow properties in comparison to their individual counterparts, which allows for better flow from the hopper to the tablet die during compression, thereby increasing content uniformity due to less mass variation [ 137 , 149 ]. Whilst better powder flow results in higher processing speeds, such compositions also demand lower lubricant concentrations, thereby lowering processing costs [ 144 , 150 ]. This technique is well suited to formulations where differences in particle size of the APIs and excipients are a concern, as pellets negate concerns of segregation within a mixture.…”

Section: Formulation Approachesmentioning

confidence: 99%

Fixed-Dose Combination Formulations in Solid Oral Drug Therapy: Advantages, Limitations, and Design Features

Wilkins,

Hamman,

Hamman

et al. 2024

Pharmaceutics

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Whilst monotherapy is traditionally the preferred treatment starting point for chronic conditions such as hypertension and diabetes, other diseases require the use of multiple drugs (polytherapy) from the onset of treatment (e.g., human immunodeficiency virus acquired immunodeficiency syndrome, tuberculosis, and malaria). Successful treatment of these chronic conditions is sometimes hampered by patient non-adherence to polytherapy. The options available for polytherapy are either the sequential addition of individual drug products to deliver an effective multi-drug regimen or the use of a single fixed-dose combination (FDC) therapy product. This article intends to critically review the use of FDC drug therapy and provide an insight into FDC products which are already commercially available. Shortcomings of FDC formulations are discussed from multiple perspectives and research gaps are identified. Moreover, an overview of fundamental formulation considerations is provided to aid formulation scientists in the design and development of new FDC products.

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“…Incompatible drugs can be combined into one preparation form and can be designed to produce different release profiles from the same drug or from different drugs. MUPS is made from pellets coated with a reservoir with a characteristic of polymer coating that can withstand compression strength, in which the coating must not be crushed or even change shape 19 .…”

Section: Coating Systemmentioning

confidence: 99%

Efforts in Improving Tablets’ Tensile Strength With a Coating System and Brittle Excipient: A Review

Ainurofiq,

Wuslatush Sholekah,

Hanifah

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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Tablets are the most in-demand pharmaceutical preparation by pharmaceutical companies or users because they provide the best capabilities from all oral preparations. Maintaining the grade and quality of tablets need to be of great concern. Factors affecting the physical quality of tablets must always be evaluated, including tensile strength. Tensile strength directly affects the process of distribution, storage, disintegration, and dissolution of tablets. Tensile strength problem is often found during tablet production with the wet granulation method, in which overgranulation often occurs, especially in high-shear wet granulation (HSWG). The solution for over granulating is the addition of brittle excipients to form a strong bond when combined, thus increasing tensile strength. An ideal tensile strength may be achieved because the mechanical strength of the tablet is increased proportionally to the increased area of the bond. Another solution to increase tensile strength is by using a coating system using the Multiple Unit Pellet Systems (MUPS). The MUPS coating system often experiences problems such as caking. This problem can be overcome using a coating polymer that is stable on high RH and supports a strong tablet formulation. The solution to the tensile strength problem with the addition of brittle excipients and coating will be reviewed in this article to increase tensile strength.

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Multiple Unit Pellet System (Mups Technology) for Development of Modified Release Fast Disintegrating Tablets: A Review

Cited by 6 publications

References 24 publications

The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium

The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium

Fixed-Dose Combination Formulations in Solid Oral Drug Therapy: Advantages, Limitations, and Design Features

Efforts in Improving Tablets’ Tensile Strength With a Coating System and Brittle Excipient: A Review

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