Controlled Hemostasis in Thoracic Surgery Using Drugs with Oxidized Cellulose

Habal, Petr; Omran, Nedal; Mandak, Jiri; Šimek, Jiřı́; Stĕtina, M

doi:10.14712/18059694.2016.40

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…The vast majority of published works were performed with haemostats based on ORC (2)(3)(4)(5)(6)(7)(8)(9). Only few papers describe the effect of ONRC haemostatic gauze (10)(11)(12)(13)(14) or felt (15)(16)(17) and only one published work compares the effect of ORC and ONRC knitted gauze in a larger group of patients (18). The works published so far show that ONRC has a similar or even superior effect (10,18).…”

Section: Comparison Of Efficacy and Safety Of Non-regenerated And Reg...mentioning

confidence: 99%

Comparison of Efficacy and Safety of Non-Regenerated and Regenerated Oxidized Cellulose Based Fibrous Haemostats

Habal

Sívková²,

Votava³

2022

Acta Med. (Hradec Kralove, Czech Repub.)

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Purpose: Various forms of local haemostats are increasingly used routinely in surgical procedures. Our work is the first comparison of the efficacy and safety of non-regenerated and regenerated oxidized cellulose based fibrous haemostats. Methods: The haemostatic efficacy and safety of fibrous haemostats based on ONRC and ORC were compared in a randomized multicenter study. The primary endpoint was successful haemostasis within 3 minutes of application and no need for surgical revision within 12 hours after the procedure for recurrent bleeding. Results: There was a significant difference in the rate of successful haemostasis in 3 minutes that was achieved in 82% and 55% in the ONRC and ORC groups, respectively (confidence interval 99%; p = 0.009). Mean time to haemostasis was 133.9 ± 53.95 seconds and 178.0 ± 82.33 seconds, in the ONRC, and ORC group, respectively (p = 0.002). Revision surgery for re-bleeding was necessary in 0 (0%), and 1 (2%) of patients in the ONRC, and ORC group, respectively. No adverse events were reported. Conclusion: Fibrous haemostat based on ONRC was non-inferior compared to fibrous haemostat based on ORC when used in accordance with its intended purpose, and was safe and efficient.

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Section: Comparison Of Efficacy and Safety Of Non-regenerated And Reg...mentioning

confidence: 99%

Comparison of Efficacy and Safety of Non-Regenerated and Regenerated Oxidized Cellulose Based Fibrous Haemostats

Habal

Sívková²,

Votava³

2022

Acta Med. (Hradec Kralove, Czech Repub.)

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“…It is important to tailor hemostatic materials to suit certain needs at the hemorrhagic site in different cases such as bone surgery and dentistry . Additionally, it is recommended that the hemostatic material should be nonimmunogenic and have antibacterial effects to avoid sepsis. − …”

Section: Introductionmentioning

confidence: 99%

Multifunctional Hemostatic PVA/Chitosan Sponges Loaded with Hydroxyapatite and Ciprofloxacin

et al. 2022

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The present study describes the development of multifunctional hemostatic sponges to control bleeding. Chitosan (Ch) and poly(vinyl alcohol) (PVA) were selected as the basic polymeric matrix [Ch/PVA] for sponges. Glycerol and citric acid were used as crosslinkers [Ch/PVA/G(Cl)] to enhance the mechanical properties of the developed sponges. Ciprofloxacin (AB) was added to the developed sponge to impart antibacterial activity. Hydroxyapatite (HA) was also added, which would make the sponge suitable for bone surgery. Among the developed sponges, the Ch/PVA/G(Cl)-HA-AB sponge demonstrated enhanced cell viability, mechanical properties, and strong antimicrobial effect against Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus , in addition to platelet aggregation activity. The addition of ciprofloxacin and hydroxyapatite promotes a unique synergistic effect of antimicrobial activity and hemostasis. Thus, the present study introduces Ch/PVA/G(Cl)-HA-AB, a multifunctional hemostatic sponge that would be suitable for bone surgical applications.

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“…In the last decades, many topical hemostatic agents have been used during surgery and their use have become a common practice (4,5). One of these substances is oxidized cellulose (OC), an absorbable passive hemostatic agent (6).…”

Section: Introductionmentioning

confidence: 99%

A lymph node mediastinal foreign body reaction mimicking nodal metastasis: A case series

et al. 2022

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IntroductionIn the last decades, many haemostatic substances included oxidized cellulose topically applied have been used during surgery and their use have become a common practice. Oxidized cellulose (OC) is one of the most used haemostatic substances. However, different studies have shown the persistence of OC deposits after surgical procedures that may simulate recurrent malignancies and abscesses. We present a case series of patients with enlarged on CT and PET-FDG positive lymphadenopathies due to foreign body inflammatory reaction to OC after lung surgery for pulmonary malignancies.MethodsRetrospective chart review of patients from 2021 to 2022 who underwent EBUS-TBNA for the characterization of hilar and/or mediastinal lymphadenopathies and a histopathological diagnosis of foreign body inflammatory reaction to OC.ResultsEight patients were referred to “Ospedali Riuniti di Ancona” (n = 7) and “Ospedale San Martino” (Genoa) (n = 1) Interventional Pulmonology Units for the characterization of hilar and/or mediastinal lymphadenopathies. All the evaluated patients underwent surgical procedures for lung cancers within the previous 12 months. EBUS-TBNA was performed in all the patients to rule out nodal metastasis. The cyto-pathological evaluation revealed amorphous acellular eosinofilic material surrounded by inflammatory reaction. As no other apparent causes might explain this finding and considering the temporal relationship between the lymphadenopathy and the lung surgery, foreign body inflammatory reaction to OC is the most likely cause of the phenomenon.ConclusionIn patients who underwent surgery for lung cancer, especially within few months, the development of lymph node foreign body reaction due to surgical material retention should always be considered.

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Controlled Hemostasis in Thoracic Surgery Using Drugs with Oxidized Cellulose

Cited by 6 publications

References 12 publications

Comparison of Efficacy and Safety of Non-Regenerated and Regenerated Oxidized Cellulose Based Fibrous Haemostats

Comparison of Efficacy and Safety of Non-Regenerated and Regenerated Oxidized Cellulose Based Fibrous Haemostats

Multifunctional Hemostatic PVA/Chitosan Sponges Loaded with Hydroxyapatite and Ciprofloxacin

A lymph node mediastinal foreign body reaction mimicking nodal metastasis: A case series

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