A lymph node mediastinal foreign body reaction mimicking nodal metastasis: A case series

Abstract

IntroductionIn the last decades, many haemostatic substances included oxidized cellulose topically applied have been used during surgery and their use have become a common practice. Oxidized cellulose (OC) is one of the most used haemostatic substances. However, different studies have shown the persistence of OC deposits after surgical procedures that may simulate recurrent malignancies and abscesses. We present a case series of patients with enlarged on CT and PET-FDG positive lymphadenopathies due to foreign body inflammatory reaction to OC after lung surgery for pulmonary malignancies.MethodsRetrospective chart review of patients from 2021 to 2022 who underwent EBUS-TBNA for the characterization of hilar and/or mediastinal lymphadenopathies and a histopathological diagnosis of foreign body inflammatory reaction to OC.ResultsEight patients were referred to “Ospedali Riuniti di Ancona” (n = 7) and “Ospedale San Martino” (Genoa) (n = 1) Interventional Pulmonology Units for the characterization of hilar and/or mediastinal lymphadenopathies. All the evaluated patients underwent surgical procedures for lung cancers within the previous 12 months. EBUS-TBNA was performed in all the patients to rule out nodal metastasis. The cyto-pathological evaluation revealed amorphous acellular eosinofilic material surrounded by inflammatory reaction. As no other apparent causes might explain this finding and considering the temporal relationship between the lymphadenopathy and the lung surgery, foreign body inflammatory reaction to OC is the most likely cause of the phenomenon.ConclusionIn patients who underwent surgery for lung cancer, especially within few months, the development of lymph node foreign body reaction due to surgical material retention should always be considered.

Foreign Body Reaction Mimicking Lymph Node Metastasis is Not Rare After Lung Cancer Resection

“…1 Furthermore, the low pH it creates helps vasoconstriction and reduces the risk of infection. 2 It begins to take effect on small arterial, venous, and capillary hemorrhages approximately 2 to 8 minutes after insertion. 3 It is an absorbable material and is expected to be absorbed within 1 to 2 weeks after the operation.…”

Commentary: A lymph node mediastinal foreign body reaction mimicking nodal metastasis: a case series

“…I read the article of Lina Zuccatosta and colleagues entitled “ A lymph node mediastinal foreign body reaction mimicking nodal metastasis: a case series ” and published on “Frontiers in Medicine” ( 1 ).…”

“…The Authors report a series of eight patients with enlarged on CT and PET-FDG positive lymphadenopathies due to foreign body inflammatory reaction to Oxidized Cellulose (OC) after lung surgery ( 1 ).…”