Controlled fabrication of multi-core alginate microcapsules

Eqbal, Danish; Gundabala, Venkat

doi:10.1016/j.jcis.2017.07.100

Cited by 27 publications

(17 citation statements)

References 34 publications

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“…Alginate gelation occurs when divalent cations (calcium ions and chitosan) interact with blocks of guluronic acid residues, leading to the formation of an egg‐box structure . This structure of alginate capsule has shown potential for use in drug delivery systems, in the immobilization of living cells, in the controlled release of functional ingredients or bioactive materials, and in masking undesirable tastes . Calcium alginate capsules have some serious drawbacks, however, such as the quick breakdown of the capsules and problems with the controlled release of drugs …”

Section: Introductionmentioning

confidence: 99%

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Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

Mohammadi

Ehsani

Bakhoda

2018

Flavour & Fragrance J

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Caffeine was encapsulated into calcium alginate microcapsules, and these microcapsules were produced with four types of material – starch, xanthan, chitosan, and whey protein isolate – in combination with alginate. Formulation characteristics such as the efficiency of microencapsulation, microcapsule size, viscosity, and texture properties of the microcapsules have been evaluated. The release of caffeine from different microcapsules was conducted in simulated saliva fluid. Alginate microcapsules with chitosan coating provided the slowest release of caffeine, compared with the other microcapsules. Significant differences in the appearance of the microcapsules were detectable by scanning electron microscopy (SEM) and optical microscopy. Fourier‐transform infrared spectrometry (FTIR) analysis confirmed the existence of carbonyl groups in caffeine‐loaded microcapsules, and differential scanning calorimetry (DSC) thermograms indicated the glass transition temperature of the microcapsules. This study showed that the microencapsulation of caffeine with alginate may be helpful for designing fast (alginate) as well as prolonged caffeine release (alginate–starch–xanthan with chitosan).

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Section: Introductionmentioning

confidence: 99%

“…bioactive materials, 17,18 and in masking undesirable tastes. 19 Calcium alginate capsules have some serious drawbacks, however, such as the quick breakdown of the capsules and problems with the controlled release of drugs.…”

mentioning

confidence: 99%

Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

Mohammadi

Ehsani

Bakhoda

2018

Flavour & Fragrance J

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“…This is an important feature of CTE as reported by earlier studies. [13,15,22] Upon complexation with SC, the luminescence of CS is almost completely quenched; whereas PS is still highly luminescent ( Figure S3E,F, Supporting Information). Energy transfer from CS or PS to SC is unlikely, owing to energy disparity and the lack of overlap between the absorption of SC and the emission of CS or PS.…”

Section: Resultsmentioning

confidence: 99%

A Bioinspired, Sustained‐Release Material in Response to Internal Signals for Biphasic Chemical Sensing in Wound Therapy

Lai

Deng

et al. 2020

Adv Healthcare Materials

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Biofluorescence in living entities is a functional process associated with information conveyance; whereas the capacity to respond to internal physiological signals is a unique property of a cell. By integrating these two biological features into materials design, a bioinspired material, namely CPS, is developed. Contrary to conventional luminescent polymeric systems whose emission comes from π‐conjugated structures, this material displays clusterization‐triggered emission. In the preclinical trial on a dermal punch model of tissue repair, it successfully increases the rate of wound closure, reduces inflammatory cell infiltration, and enhances collagen deposition. It can also relay changes in internal chemical signals into changes in its intrinsic luminescence for biphasic chemical sensing to prevent possible occurrence of skin hyperpigmentation caused by minocycline hydrochloride in wound therapy. Together with its ease of fabrication, high biocompatibility, high drug loading efficiency, and high release sustainability, CPS shows high potential to be developed into an intelligent solid‐state device for wound treatment in the future.

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“…When microcracks in propagation encounter capsules, they trigger to rupture, and the rejuvenator fills the cracks by capillarity reconstituting the chemical composition of bitumen caused by ageing [4]. For this, low-cost and low-environmental impact rejuvenators such as cooking oil [5] and bio-oil [6] have been encapsulated using alginate, a biopolymer presenting nontoxicity, excellent biocompatibility, easy gelation, and long-term stability [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterisation of biocapsules containing low-cost rejuvenators for asphalt self-healing

et al. 2021

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This study aimed to characterise polynuclear biocapsules containing low-cost rejuvenating agents for asphalt self-healing. Capsules consisted of a biopolymeric matrix of calcium alginate containing cooking oil and mineral oil as rejuvenating agents, being synthesised using ionic gelation through the pumping dripping technique. The physical-chemical properties of the oil-in-biopolymer emulsions and their stability over time were studied. The morphological and thermophysical properties of the biocapsules, as well as the encapsulation efficiency of the rejuvenating agents, were quantified and characterised by microscopic techniques and laboratory tests. Main results showed that emulsions should be used for encapsulation purposes within a period no longer than 3h, reducing the effect of instability phenomena. Besides, the biopolymer-based polynuclear capsules presented uniform size, internal multicavity microstructure resulting in high encapsulation efficiencies and thermal stability at high temperatures, proving that cooking oil and mineral oil can be potentially used as low-cost rejuvenating agents and thermally stable additives for asphalt self-healing purposes.

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Controlled fabrication of multi-core alginate microcapsules

Cited by 27 publications

References 34 publications

Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

A Bioinspired, Sustained‐Release Material in Response to Internal Signals for Biphasic Chemical Sensing in Wound Therapy

Synthesis and characterisation of biocapsules containing low-cost rejuvenators for asphalt self-healing

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