A Bioinspired, Sustained‐Release Material in Response to Internal Signals for Biphasic Chemical Sensing in Wound Therapy

Abstract

Biofluorescence in living entities is a functional process associated with information conveyance; whereas the capacity to respond to internal physiological signals is a unique property of a cell. By integrating these two biological features into materials design, a bioinspired material, namely CPS, is developed. Contrary to conventional luminescent polymeric systems whose emission comes from π‐conjugated structures, this material displays clusterization‐triggered emission. In the preclinical trial on a dermal punch model of tissue repair, it successfully increases the rate of wound closure, reduces inflammatory cell infiltration, and enhances collagen deposition. It can also relay changes in internal chemical signals into changes in its intrinsic luminescence for biphasic chemical sensing to prevent possible occurrence of skin hyperpigmentation caused by minocycline hydrochloride in wound therapy. Together with its ease of fabrication, high biocompatibility, high drug loading efficiency, and high release sustainability, CPS shows high potential to be developed into an intelligent solid‐state device for wound treatment in the future.

ROS-Generating Amine-Functionalized Magnetic Nanoparticles Coupled with Carboxymethyl Chitosan for pH-Responsive Release of Doxorubicin

“…Apart from metal nanoparticles, natural biodegradable polymers are advancing the research front in bioactive agent delivery. [22][23][24][25] For instance, chitin and its derivatives have been employed to administer drugs or nutritional supplements.- 26 One of the most widely studied derivatives of chitin is chitosan (CS), [27][28][29][30] whose various favourable properties (including the film-forming ability, the antibacterial activity, the ability to interact with different substances, and the high solubility across a wide pH range) enabling it and its derivatives to be adopted not only in wound therapy 31 and cancer treatment 32,33 but also in immunological modulation. 34 In this study, we combine carboxymethyl CS (CMC), which is a biocompatible and biodegradable polymer possessing free hydroxyl, amino, and carboxylic groups to cross-link with diverse functional groups found in bioactive compounds, 35 with ROS-generating magnetic metal nanoparticles to fabricate a bioactive carrier for pH-responsive release of the loaded agent.…”

Design and Practical Considerations for Active Polymeric Films in Food Packaging

“…An alternative to natural polymers are synthetic polymers [ 40 , 41 , 42 , 43 , 44 ]. One example is polyethylene (PE), which has been adopted in food packaging since the 1940s [ 45 ].…”

Advances in the Analysis of Pharmaceuticals by Using Graphene‐Based Sensors

“…Owing to the gradual sophistication of sensor development and material engineering techniques, [111][112][113][114][115][116] graphene-based sensors have already played important role not only in basic research but also in real-life contexts. One example is the rGObased carbon paste electrode (CPE) developed for potentiometric determination of trihexyphenidyl hydrochloride in pharmaceutical and biological matrices.…”