Controlled Evaluation of a Bandage Contact Lens and a Topical Nonsteroidal Anti-inflammatory Drug in Treating Traumatic Corneal Abrasions

Donnenfeld, Eric D.; Selkin, Bryan A.; Perry, Henry D.; Moadel, Ken; Selkin, Gilbert T.; Cohen, Adam J.; Sperber, Lawrence T.B.

doi:10.1016/s0161-6420(95)30926-8

Cited by 60 publications

(43 citation statements)

References 7 publications

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“…Therapeutic contact lenses promote epithelial migration, basement membrane regeneration, and epithelial-stromal adhesion by protecting the ocular surface from the sweeping action of the upper lid. 51 Collagen corneal bandage lenses have also been reported to accelerate re-epithelialisation and to prevent relapses of recurrent erosions. 52,53 However, long-term continuous use of contact lenses may predispose to bacterial keratitis, vascularisation, and scarring.…”

Section: Therapeutic Bandage Contact Lensesmentioning

confidence: 99%

Pathogenesis, clinical features and management of recurrent corneal erosions

Ramamurthi

Rahman

Dutton

et al. 2005

Eye

109

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Recurrent corneal erosions (RCE) are common. They are characterised by repeated episodes of pain, difficulty in opening the eyes, watering, and photophobia resulting from poor epithelial adhesion. In the majority of patients with RCE, trauma is the initiating factor. Epithelial, stromal, and endothelial corneal dystrophies have all been described in association with RCE. Other causes that may lead to RCE include chemical and thermal injuries, previous herpetic keratitis, meibomian gland dysfunction, ocular rosacea, diabetes mellitus, Salzmann's nodular degeneration, band keratopathy, previous bacterial ulceration, kerato-conjunctivitis sicca, and epidermolysis bullosa. The conditions that are associated with RCE can be either primary or secondary depending on whether the basement membrane complex abnormality is intrinsic or acquired. Primary types tend to be bilateral, symmetrical and develop in multiple corneal locations. The pathogenetic mechanism of this disorder is related to poor adhesion of the corneal epithelium to the underlying stroma. Excessive matrix metalloproteinase (MMP) activity may play a role in the pathogenesis. Although the majority of patients will respond to simple measures such as padding and antibiotic ointment, RCE resistant to simple measures require approaches that are more elaborate. The common goal of these approaches is to encourage proper formation of adhesion complexes between the epithelium and the stroma. The use of longterm contact lenses, autologous serum eye drops, botulinum toxin, induced ptosis, oral MMP inhibitors, diamond burr polishing of Bowman's membrane have been reported with varying degree of success in treating RCE. Anterior stromal puncture with insulin needles or Neodymium : aluminium-yttriumgarnet may enhance the epithelial adhesion to the basement membrane by scar formation and success rates of up to 80% have been reported in the treatment of recalcitrant RCE. Excimer laser photo-therapeutic keratectomy (PTK) is now a well-established treatment modality for RCE and is being used both safely and effectively. Partial ablation of Bowman's layer with PTK gives a smooth surface for the newly generating epithelium to migrate and form adhesion complexes. The pathogenesis, clinical features, and management options of this common disorder are discussed in this review article.

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Section: Therapeutic Bandage Contact Lensesmentioning

confidence: 99%

Pathogenesis, clinical features and management of recurrent corneal erosions

Ramamurthi

Rahman

Dutton

et al. 2005

Eye

109

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“…14,20 Subsequent studies have also reported that bandage contact lenses are effective in reducing pain and enabling patients to engage in immediate activities. 10Y13 Our study also has more or less the same findings as previous research.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Bandage Contact Lenses and Pressure Patching on the Erosion Area and Pain Scale in Patients With Corneal Erosion

Triharpini¹,

Jayanegara²,

Handayani³

et al. 2015

Asia-Pacific Journal of Ophthalmology

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“…In the past, researchers have attempted to reduce postoperative surface pain following procedures such as vitreoretinal surgery, 4 refractive surgery, 5-7 and corneal abrasions 8,9 using large bandage contact lenses, nonsteroidal anti-inflammatory agents, and pressure patches. This study describes the use of a biodegradable polymer to temporarily coat the ocular surface and try to alleviate surface pain.…”

Section: Discussionmentioning

confidence: 99%