Controllable self-patterning behaviours of flexible self-assembling peptide nanofibers

Abstract

In recent years, fabricating flexible one-dimensional nanofibers with high aspect ratio and controlling their two-dimensional patterns on certain surface have attracted more and more attention. Although molecular self-assembly as a...

Advances in hybrid peptide-based self-assembly systems and their applications

“…4e and f ). 98 Fibre-like structures were formed at low pH, which changed into homogeneous spheres with less intensive H-bonding at pH 8. At higher pH, the curvature of the self-assembled structure increased due to strong electrostatic repulsion, which was balanced at low pH.…”

“…Furthermore, the intermolecular bonding arrangement also changes in response to acidic or basic solution. [97][98][99] For a peptide sample to change its assembling pattern, the pH of the solution needs to change gradually. A sudden jump in pH can disrupt the self-assembling ability of a peptide due to drastic conformational changes.…”

“…TEM image of a DGGAAVVD peptide (e) showing a fibre-like morphology at pH 5.0 and (f ) a homogeneous spherical aggregate at pH 8.0. Adapted with permission 98. Copyright 2021, Royal Society of Chemistry.…”