Advances in hybrid peptide-based self-assembly systems and their applications

Abstract

Self-assembly of peptides demonstrate a great potential for designing highly ordered, finely tailored supramolecular arrangements enriched with high specificity, improved efficacy and biological activity. Along with natural peptides, hybrid peptide...

Visualizing the global trends of peptides in wound healing through an in‐depth bibliometric analysis

“…The modularity Q value and Silhouette value, as the basic indicators, were employed to gauge the network's clustering effect and homogeneity, respectively. A Q value higher than 0.3 implies that the community structure is consequential; an S value higher than 0.5 indicates that clustering is credible, and an S value higher than 0.7 means that clustering is persuasive 28 . The modular Q value was 0.9564, and the mean silhouette S value peaked at 0.9773 (Figure S1), indicating outstanding network homogeneity and clustering impact.…”

“…Generally, due to α‐helix and 𝛽‐sheet conformations, hydrophobic effect and electrostatic forces, the structure of self‐assembly peptides including nanotubes, nanospheres, fibre bundles, and 3D network‐nanofibers 7 . Therefore, peptide‐based molecules and drug delivery have also shown considerable potential for multimodal treatment due to their multifunctionality, good biocompatibility, various forms, and ease of design and synthesis during complicated wound processes 10,28,29 . For instance, lots of bionic hydrogel constructed by self‐assembly peptides for skin wound healing, 30 spinal cord regeneration 31 and liver injury 32 .…”

“… 7 Therefore, peptide‐based molecules and drug delivery have also shown considerable potential for multimodal treatment due to their multifunctionality, good biocompatibility, various forms, and ease of design and synthesis during complicated wound processes. 10 , 28 , 29 For instance, lots of bionic hydrogel constructed by self‐assembly peptides for skin wound healing, 30 spinal cord regeneration 31 and liver injury. 32 Although various reviews have focused on the application of peptides in wound healing, there is a lack of comprehensive analysis to clarify the current trends and hotspots.…”

ROS-Responsive Methionine-Containing Amphiphilic Peptides Impart Enzyme-Triggered Phase Transition and Antioxidant Cell Protection

“…The redox reactivity of Met has inspired the design of biomaterials responsive to ROS. − Redox-responsive polypeptides based on Met have been designed to control properties such as the thermal phase transition upon oxidation . In addition, self-assembling peptides − have been recognized as highly important components for designing biomaterials. Alternating hydrophilic and hydrophobic amino acid sequences is often used to design hydrogel-forming amphiphilic peptides that aggregate through hydrophobic interactions and β-sheet formation.…”

Biodegradation of Amphipathic Fluorinated Peptides Reveals a New Bacterial Defluorinating Activity and a New Source of Natural Organofluorine Compounds

“…Self-assembling peptides (SAPs), which are composed of alternating hydrophobic/hydrophilic amino acid residues, are of interest in applications in tissue engineering owing to their biocompatibility, ease of biodegradation, and biofunctionality. , Inclusion of fluorinated amino acids can fine tune the biophysical properties of amphipathic peptide hydrophobicity, peptide secondary structure formation/protein folding, and self-assembly, often with favorable outcomes. − However, most studies focused on the single and site-specific replacement of canonical amino acids with their fluorinated counterparts, whereas the chemical and biological nature of synthetic peptides containing a large proportion of fluorinated amino acids remains largely unexplored. We recently designed a small library of cationic (Lys-rich) and polyfluorinated SAPs including the iterative incorporation of either α-aminobutyric acid (Abu), (2 S )-4-monofluoroethylglycine (MfeGly), (2 S )-4,4-difluoroethylglycine (DfeGly), and (2 S )-4,4,4-trifluoroethylglycine (TfeGly) as hydrophobic components.…”