Contribution to the Optimization of a Gas Chromatographic Method by QbD Approach used for Analysis of Essential Oils from Salvia officinalis

Robu, Silvia; Romila, Aurelia; Buzia, Olimpia Dumitriu; Spac, A; Diaconu, Camelia Cristina; Tutunaru, Dana; Lisa, E. Hensley; Nechita, Aurel

doi:10.37358/rc.19.6.7266

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…A variety of analytical methods for medicinal plants have been developed through an AQbD approach, such as the mass spectrometry analysis [ 84 , 85 ], capillary electrophoresis analysis [ 86 , 87 , 88 ], supercritical fluid chromatography analysis [ 89 , 90 ], gas chromatography analysis [ 91 , 92 ] and so on. Applications of AQbD to the development a HPLC analysis were announced in many studies [ 36 , 37 , 38 , 39 , 40 , 48 , 49 ].…”

Section: Perspectives : Challenges and Prospectsmentioning

confidence: 99%

Analytical Quality by Design (AQbD) Approach to the Development of Analytical Procedures for Medicinal Plants

Park

Kim

et al. 2022

Plants

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Scientific regulatory systems with suitable analytical methods for monitoring quality, safety, and efficacy are essential in medicinal plant drug discovery. There have been only few attempts to adopt the analytical quality by design (AQbD) strategy in medicinal plants analysis over the last few years. AQbD is a holistic method and development approach that understands analytical procedure, from risk assessment to lifecycle management. The enhanced AQbD approach reduces the time and effort necessary to develop reliable analytical methods, leads to flexible change control through the method operable design region (MODR), and lowers the out-of-specification (OOS) results. However, it is difficult to follow all the AQbD workflow steps in the field of medicinal plants analysis, such as defining the analytical target profiles (ATPs), identifying critical analytical procedure parameters (CAPPs), among others, because the complexity of chemical and biological properties in medicinal plants acts as a barrier. In this review, various applications of AQbD to medicinal plant analytical procedures are discussed. Unlike the analysis of a single compound, medicinal plant analysis is characterized by analyzing multiple components contained in biological materials, so it will be summarized by focusing on the following points: Analytical methods showing correlations within analysis parameters for the specific medicinal plant analysis, plant raw material diversity, one or more analysis targets defined for multiple phytochemicals, key analysis attributes, and analysis control strategies. In addition, the opportunities available through the use of design-based quality management techniques and the challenges that coexist are also discussed.

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Section: Perspectives : Challenges and Prospectsmentioning

confidence: 99%

Analytical Quality by Design (AQbD) Approach to the Development of Analytical Procedures for Medicinal Plants

Park

Kim

et al. 2022

Plants

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“…For example, there are studies about the development of HPLC-UV/PDA methods for the analysis of flavonoids [ 13 , 14 ], saponins [ 15 , 16 ], terpenoids [ 17 ], quinones [ 9 ], and phenolic [ 18 ]; HPLC-MS methods to determine terpene lactones [ 19 ] and polyphenols [ 20 ]; HPLC-ELSD methods to quantify sugars and their derivatives [ 21 ], etc. In addition, other chromatographic methods have also been developed based on AQbD, such as capillary electrophoresis [ 22 , 23 ], supercritical fluid chromatography [ 24 , 25 ], gas chromatography [ 26 , 27 ], etc. However, the practice of applying APLC and AQbD to developing qNMR methods for herbal medicines has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Application of the Analytical Procedure Lifecycle Concept to a Quantitative 1H NMR Method for Total Dammarane-Type Saponins

Yang

Zhao

et al. 2023

Pharmaceuticals

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Dammarane-type saponins (DTSs) exist in various medicinal plants, which are a class of active ingredients with effects on improving myocardial ischemia and immunomodulation. In this study, a quantitative 1H NMR method of total DTSs in herbal medicines was developed based on the analytical procedure lifecycle. In the first stage (analytical procedure design), the Ishikawa diagram and failure mode effects and criticality analysis were used to conduct risk identification and risk ranking. Plackett–Burman design and central composite design were used to screen and optimize critical analytical procedure parameter. Then, the method operable design region was obtained through modeling. In the second stage (analytical procedure performance qualification), the performance of methodological indexes was investigated based on analytical quality by design. As examples of continued procedure performance verification, the method was successfully applied to determine the total DTSs in herbal pharmaceutical preparations and botanical extracts. As a general analytical method to quantify total DTSs in medicinal plants or pharmaceutical preparations, the developed method provides a new quality control strategy for various products containing dammarane-type saponin.

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“…The representatives of Lamiaceae family (Salvia, Lavandula, Mentha, Origanum etc.) are aromatic species, known for their flavoring properties due to essential oil [5,13,21,25]. Teucrium genus is not as known and investigated as other Lamiaceae representatives, but some of its variations are presently used as medicinal (Teucrium chamaedrys L., T. montanum L.) or food spices (Teucrium polium L.) in many traditional communities throughout the world (Greece, Spain, Turkey, Iran, Morocco, etc.).…”

Section: Introductionmentioning

confidence: 99%

Comparative Chemical and Biological Activity of Selective Herbal Extracts

Humulescu¹

2021

FARMACIA

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Contribution to the Optimization of a Gas Chromatographic Method by QbD Approach used for Analysis of Essential Oils from Salvia officinalis

Cited by 7 publications

References 17 publications

Analytical Quality by Design (AQbD) Approach to the Development of Analytical Procedures for Medicinal Plants

Analytical Quality by Design (AQbD) Approach to the Development of Analytical Procedures for Medicinal Plants

Application of the Analytical Procedure Lifecycle Concept to a Quantitative 1H NMR Method for Total Dammarane-Type Saponins

Comparative Chemical and Biological Activity of Selective Herbal Extracts

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