Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil

Fukuda, Yasuko; Nagata, Minoru; Osawa, Toshihiko; Namiki, Mitsuo

doi:10.1007/bf02673792

Cited by 264 publications

(186 citation statements)

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“…1 TEMPOL was purchased from Sigma-Aldrich Chem. Co. (St. Louis, MO) and dissolved in physiological saline (Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan) at a concentration of 200 mM.…”

Section: Reagentsmentioning

confidence: 99%

“…1). 1 The multiple biological functions of sesamin and episesamin that have been previously reported include the inhibition of ∆5-desaturase, 2 antioxidant activities, [3][4][5][6][7][8] and anti-inflammatory and antihypertensive effects. [8][9][10] Several studies have described the suppressive effects of sesamin on lipid peroxidation in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antioxidative Effects of Sesamin on the In vivo Hepatic Reducing Abilities by a Radiofrequency ESR Method

et al. 2013

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Antioxidative effects of sesamin (a mixture of sesamin and episesamin) were evaluated in the liver, kidney and inferior vena cava of living rats using a radiofrequency ESR method. TEMPOL, 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl, was used as an in vivo redox probe, the half-life of which is believed to be correlated with the antioxidant status. The oral administration of sesamin (250 mg/kg rat weight) 3 h before ESR measurements shortened the half-life of TEMPOL in the liver by 10 -15% as compared with the controls, but did not affect the other organs. This effect was maintained for at least 3 h after the administration, and then disappeared at 24 h, corresponding to the results of our preliminary pharmacokinetic studies. Changes in the reducing ability were observed only in the hepatic sites of the sesamin-treated rats. These findings suggest that sesamin exhibits effective antioxidant activity in the liver via modulation of the intracellular redox status related to TEMPOL reduction.

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“…1 TEMPOL was purchased from Sigma-Aldrich Chem. Co. (St. Louis, MO) and dissolved in physiological saline (Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan) at a concentration of 200 mM.…”

Section: Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidative Effects of Sesamin on the In vivo Hepatic Reducing Abilities by a Radiofrequency ESR Method

et al. 2013

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“…Lignans Sesame lignans are prepared by the method of Fukuda et al (2) from refined sesame seed oil. Sesame lignans were analyzed by HPLC method and it was 97.5% pure (sesamin : episesamin 51.4:48.6, w/w).…”

Section: Preparation and Analysis Of Sesamementioning

confidence: 99%

“…Sesame lignans (sesamin and episesamin) are compounds commonly found in refined sesame oil. Episesamin, one of the important components of sesame lignans is generated from equivalent amount of sesamin by isomerization during the acid-clay bleaching of oil (2). Sesame lignans have multiple physiological functions including antioxidant activity (3), antihypertensive effects (4) in rats and alleviation of hepatic injury caused by alcohol or carbon tetrachloride (5) in mice.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Effect of Sesame Lignans in Diabetes Mellitus Blood: an in vitro study

Dhar¹,

Chattopadhyay

Bhattacharyya

et al. 2005

J. Oleo Sci.

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Refined and bleached sesame oil (Sesamum indicum L.) contains sesame lignans, mainly sesamin and episesamin, and they are isolated from refined sesame oil. The in vitro antioxidant properties of sesame lignans and sesamol are investigated on oxidative modification of human plasma, low-density lipoprotein (LDL) and erythrocyte membrane lipid. Blood samples are collected from diabetic and non-diabetic (normal) healthy individuals. Sesame lignans and sesamol are added at 0.05% and 0.1% concentrations to plasma, LDL and erythrocyte membrane isolated from the respective blood samples and peroxidations are determined against control samples. A significant increase of peroxidation levels was observed consequently in diabetic control blood and the non-diabetic control blood. Sesamol and sesame lignans decreased lipid peroxidation. The findings suggest that sesamol and sesame lignans (mainly sesamin and episesamin) are potentially effective antioxidants that can protect plasma, LDL and erythrocyte membrane from oxidation which may be effective in reducing the risk of coronary heart disease in diabetes.

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“…The DNA G+C content of species ranges from 36 to 59 mol% (Ash et al, 1993;Shida et al, 1997;De Vos et al, 2009). In this communication, we describe the polyphasic taxonomic characterization of a sesaminol-producing bacterium, strain KB0549 T , which was isolated from sesame oil cake (SOC) and was determined to be affiliated with the genus Paenibacillus.Sesaminol is one of several lignans found in sesame oil, having strong antioxidant activity as well as a variety of health benefits to humans (Fukuda et al, 1986;Kang et al, 1998;Kumazawa et al, 2003). Sesame seeds contain large amounts of sesaminol in glycosidic form.…”

mentioning

confidence: 99%

Paenibacillus relictisesami sp. nov., isolated from sesame oil cake

Shimoyama

Johari

Tsuruya

et al. 2014

International Journal of Systematic and Evolutionary Microbiology

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A facultatively anaerobic, Gram-stain-positive, rod-shaped bacterium, designated strain KB0549 T , was isolated from sesame oil cake. Cells were motile, round-ended rods, and produced central or terminal spores. The cell wall peptidoglycan contained meso-diaminopimelic acid as the diamino acid. The major fatty acids were anteiso-C 15 : 0 and anteiso-C 17 : 0 . The DNA G+C content of strain KB0549 T was 51.9 mol%. On the basis of 16S rRNA gene sequence phylogeny, strain KB0549 T was affiliated with the genus Paenibacillus in the phylum Firmicutes and was most closely related to Paenibacillus cookii with 97.4 % sequence similarity. Strain KB0549 T was physiologically differentiated from P. cookii by the high content of anteiso-C 17 : 0 , inability to grow at 50 6C, spore position, and negative Voges-Proskauer reaction. Based on these unique physiological and phylogenetic characteristics, it is proposed that the isolate represents a novel species, Paenibacillus relictisesami sp. nov.; the type strain is KB0549 T (5JCM 18068 T 5DSM 25385 T ). Ash et al. (1993) proposed that 11 strains belonging to 'Group 3' within the genus Bacillus should be transferred to the genus Paenibacillus. The descriptions of Paenibacillus amylolyticus, Paenibacillus illinoisensis and Paenibacillus chibensis as species within the genus Paenibacillus were later amended by Shida et al. (1997). At the time of writing, the genus Paenibacillus contains 147 species and four subspecies (http://www.bacterio.net/p/paenibacillus.html).Members of the genus Paenibacillus are aerobic or facultatively anaerobic, rod-shaped, endospore-forming bacteria. Species of this genus have been isolated from various sources, including soil (Yoon et al., 2007), rhizosphere (Daane et al., 2002;Kuisiene et al., 2008), compost (Iida et al., 2005Ueda et al., 2013), warm springs (Saha et al., 2005) and human faeces (Hoyles et al., 2012). Several of the characterized strains have useful enzymic activities; for example, Paenibacillus sp. JDR-2 produces xylanase and is, therefore, able to utilize hemicellulosic polysaccharides (St John et al., 2006). Members of the genus Paenibacillus contain meso-diaminopimelic acid as the major diamino acid in peptidoglycan, and have anteiso-C 15 : 0 as the major cellular fatty acid. The DNA G+C content of species ranges from 36 to 59 mol% (Ash et al., 1993;Shida et al., 1997;De Vos et al., 2009). In this communication, we describe the polyphasic taxonomic characterization of a sesaminol-producing bacterium, strain KB0549 T , which was isolated from sesame oil cake (SOC) and was determined to be affiliated with the genus Paenibacillus.Sesaminol is one of several lignans found in sesame oil, having strong antioxidant activity as well as a variety of health benefits to humans (Fukuda et al., 1986;Kang et al., 1998;Kumazawa et al., 2003). Sesame seeds contain large amounts of sesaminol in glycosidic form. Sesaminolis the most abundant lignan in sesame seeds and is therefore a potentially important source of sesaminol. However, due to its bra...

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Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil

Cited by 264 publications

References 10 publications

Evaluation of Antioxidative Effects of Sesamin on the In vivo Hepatic Reducing Abilities by a Radiofrequency ESR Method

Evaluation of Antioxidative Effects of Sesamin on the In vivo Hepatic Reducing Abilities by a Radiofrequency ESR Method

Antioxidative Effect of Sesame Lignans in Diabetes Mellitus Blood: an in vitro study

Paenibacillus relictisesami sp. nov., isolated from sesame oil cake

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