Antioxidative Effect of Sesame Lignans in Diabetes Mellitus Blood: an in vitro study

Dhar, Pubali; Chattopadhyay, Kalicharan; Bhattacharyya, Debasish; Ghosh, Santinath

doi:10.5650/jos.54.39

Cited by 8 publications

(6 citation statements)

References 18 publications

(11 reference statements)

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“…Oxidative stress is involved in the pathogenesis of CVDs, hence why diabetic patients also have a higher risk of developing cardiovascular complications ( Oguntibeju, 2019 ). A study investigating the effect of sesamin on peroxidation levels of diabetic blood samples concludes that the antioxidant properties of sesamin can potentially protect plasma, LDL, and erythrocyte membrane from oxidation, and thus reduce the risk of developing coronary heart disease ( Dhar et al, 2005 ). Moreover, sesamin is found to possess cardioprotective properties ( Thuy et al, 2017 ).…”

Section: Effects Of Sesamin On Diabetesmentioning

confidence: 99%

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Dalibalta

Majdalawieh

Manjikian

2020

Saudi Pharmaceutical Journal

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Sesamin, a major lignin isolated from sesame ( Sesamum indicum ) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro , and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.

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Section: Effects Of Sesamin On Diabetesmentioning

confidence: 99%

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Dalibalta

Majdalawieh

Manjikian

2020

Saudi Pharmaceutical Journal

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“…137,138 With respect to plasma LDL control, there is substantial data indicating that lignans, as a class, act as effective antioxidants in preventing LDL cholesterol from being oxidized, rendering them less atherogenic. [139][140][141][142] This finding was substantiated by Kangas et al, 140 who demonstrated that 7 hydroxy-matairesinol (from Picea abies) is incorporated into isolated LDL fractions to protect LDL cholesterol from being oxidized. Surprisingly, the LDL oxidation inhibition efficiency of hydroxyl-matairesinol is approximately 50% of that of vitamin E, whereas its peroxyl radical scavenging ratio is 4:1 versus 2:1 for vitamin E, indicating a less effective/different mode of action.…”

Section: Lignansmentioning

confidence: 96%

“…Soy lignans (∼2 mg/100 g of beans, effective dose ∼100 mg/day) comprise isolariciresinol (29%; Figure 1F), pinoresinol (21%; Figure 1G), syringaresinol (18%), secoisolariciresinol (16%), lariciresinol (14%), and matairesinol (1%), which are dietary precursors of the mammalian lignans enterolactone and enterodiol 137,138 . With respect to plasma LDL control, there is substantial data indicating that lignans, as a class, act as effective antioxidants in preventing LDL cholesterol from being oxidized, rendering them less atherogenic 139–142 . This finding was substantiated by Kangas et al., 140 who demonstrated that 7 hydroxy‐matairesinol (from Picea abies ) is incorporated into isolated LDL fractions to protect LDL cholesterol from being oxidized.…”

Section: Lignansmentioning

confidence: 97%

Soy constituents: modes of action in low-density lipoprotein management

Ee¹

2009

Nutrition Reviews

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Reviewed here are the modes of action of soy components used as ingredients in foods, which can lower plasma levels of low-density lipoprotein (LDL) and cholesterol, which are markers for the risk for atherosclerosis. Soy ingredients act via more than one mode of action including the following: LDL absorption suppression, cholesterol efflux stimulation, LDL resorption stimulation, LDL oxidation prevention, LDL particle size increase, cholesterol synthesis reduction, and bile secretion increase. Individual genetics, lifestyle, and nutrition habits alter LDL management and a better understanding of the various modes of actions of soy ingredients may facilitate the composition of effective ingredient cocktails. The optimization of food components offers further alternatives to LDL management to augment drug therapy for patients who are unable to reach their target LDL cholesterol levels or who are suffering from side effects or drug insensitivity.

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“…참깨는 아시아에서 재배 되는 아주 중요한 유지 종자 곡물로 인도가 세계생산량 의 약 27%를 차지하고 있다. 참기름의 강력한 산화에 대한 안정성은 sesamol 때문이고 이는 자연오일에서 매 우 소량만 존재한다 [14]. …”

Section: 서 론unclassified

A Study on the Anti-wrinkle Activities of Sesamum indicum L. Ethanol Extracts on CCD-986sk

주다혜¹,

유단희²,

이진영³

2016

Journal of the Society of Cosmetic Scientists of Korea

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요 약: 본 연구에서는 참깨 추출물의 주름개선 화장품 원료로의 가능성을 확인하기 위하여, 참깨의 70% 에탄올 추출물을 제조하여, 엘라스타제 저해능, 콜라게나제 저해능, matrixmetallopoteinases (MMPs)의 단백질, mRNA 발현 저해 효능을 측정하였다. Elastase와 collagenase 저해활성은 1000 µg/mL 농도에서 각각 37.8%와 45%의 효소 활성을 억제를 나타내었다. 섬유아세포에서 참깨 에탄올 추출물의 세포 생존율을 확인한 결과 100 µg/mL 농도에서 96%의 생존율을 보였다. 참깨 에탄올 추출물을 처리한 섬유아세포에서 matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3)의 단백질 발현 및 mRNA 발현 억제 효과를 확인한 결과 단백질 발현은 100 µg/mL 농도에서 63%, 43%, 49%의 저해율을 나타내었고, mRNA 발현 억제는 최고농도인 100 µg/mL에서 각각 82% 79%, 82%의 저해율을 나타내었다. 이러한 결과로 보아 참깨 70% 에탄올 추출물이 주름개선용 기능성 화장품 소재로서의 응용이 가능할 것으로 판단되었다. Abstract:In order to investigate the possibility of Sesamum indicum L. (S. indicum) extract as an active ingredient for wrinkle-care cosmetics, we prepared 70% ethanolic extract of S. indicum and measured its elastase inhibitory activity and collagenase inhibitory activity. We also evaluated the effect of S. indicum extract on protein and mRNA expression of MMPs in fibroblast cell (CCD-986sk). For anti-wrinkle effects, elastase inhibition activities and collagenase inhibition activities were 37.8% and 45% at a dose of 1,000 µg/mL of S. indicum 70% ethanol extract. For a cell viability test, measured on fibroblast cell by ethanol extract of S. indicum, results showed 96% with cell viability at 100 µg/mL concentration. According to the results of western blot of ethanol extract from S. indicum the expression of the matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3) protein was decreased by 63%, 43%, 49% at 100 µg/mL concentration. Reverse transcription-polymerase chain reaction (PCR) of ethanol extract from S. indicum showed that the expression of MMP-1, MMP-2, MMP-3 mRNA was decreased by 82%, 79%, 82% at 100 µg/mL concentration. The findings suggest that 70% ethanol extract from S. indicum has potential as a cosmeceutical ingredient with anti-wrinkle effects.

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Antioxidative Effect of Sesame Lignans in Diabetes Mellitus Blood: an in vitro study

Cited by 8 publications

References 18 publications

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Health benefits of sesamin on cardiovascular disease and its associated risk factors

Soy constituents: modes of action in low-density lipoprotein management

A Study on the Anti-wrinkle Activities of Sesamum indicum L. Ethanol Extracts on CCD-986sk

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