Contribution of CB1Rs in anxiety-related behaviors but not locomotor deficits induced by methamphetamine

Ramshini, Effat; Sepehri, Gholamreza; Ahmadi-Zeidabadi, Meysam; Arjmand, Shokouh; Khaksari, Mohammad; Shabani, Mohammad

doi:10.1016/j.neulet.2017.12.021

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…For histology study, METH (5 mg/kg) was dissolved in isotonic (0.9% NaCl) saline. WIN (3 mg/kg) 26 and SR (10 mg/kg) were dissolved in a mixture of sterile isotonic saline and anhydrous dimethyl sulfoxide (DMSO, 9:1 v/v) added one drop of 0.4% Tween oil-80 as dispersing or emulsifier agent.…”

Section: Methodsmentioning

confidence: 99%

Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells

et al. 2020

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Our previous studies on cannabinoid type1 receptor (CB1R) activation on Methamphetamine (METH)-induced neurodegeneration and locomotion impairments in male rats suggest an interaction between CB1Rs and METH. However, the role of these receptors in METH-neurotoxicity has not been fully identified. Therefore, the purpose of the present study is to investigate the involvement of CB1Rs in these effects. We conducted an electrophysiological study to evaluate functional interactions between METH and CB1Rs using whole-cell patch current clamp recording. Furthermore, we designed the Nissl staining protocol to assess the effect of METH on the basic cerebellar Purkinje cell structure. Our findings revealed that METH significantly increased the action potential half-width, spontaneous interspike intervals, first spike latency, and decreased the rebound action potential and spontaneous firing frequency. Using CB1R agonist and antagonist, our results showed a significant interaction with some of the electrophysiological alterations induced by METH. Further, Nissl staining revealed that the exposure to the combination of METH and SR141716A resulted in the necrotic cell death. Results of the current study raises the possibility that METH consumption profoundly affect the intrinsic membrane properties of cerebellar Purkinje neurons and cannabinoid system manipulations may counteract some of these effects. In summary, our findings provide further insights into the modulatory role of the endocannabinoid system in METH-induced neurologic changes, which can be used in the development of potential therapeutic interventions for METH dependence.

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Section: Methodsmentioning

confidence: 99%

Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells

et al. 2020

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“…The animals were placed inside a pre-cleaned 50 × 80 × 80 cm box, with a camera on the box. The animal's level of locomotor activity and exploration including rearing, grooming and crossing was recorded for 5 min to be analyzed later (19).…”

Section: Open Field Testmentioning

confidence: 99%

The Effects of Urtica Dioica Root and Rosa Damascena Mill Petal Extracts on Andropause symptoms and Reproductive Characteristics of Middle-age Male Rats

esfahlani,

Haghpanah,

Afarinesh

et al. 2024

Preprint

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Background Andropause starts in middle-aged men and affects hormonal balance and behavioral/sexual functions. The aim of the present study was to determine the effects of two Rosa Damascena Mill. (Rosaceae, Rosa) and Urtica dioica L. (Urticaceae, Urtica); in relieving andropause symptoms due to their antioxidant and reproductive properties. Methods Animals were allocated into five groups including the young, control vehicle, Rosa, Urtica and Rosa + Urtica groups. Behavioral tests were performed. Sperm parameters and sex hormones were also assessed. Results Both extracts, especially in combined form increased preference index and muscle strength and decreased the level of depression significantly. Semen quality increased in the extract-treated groups. Testosterone level was increased significantly in the Rosa + Urtica group in middle-aged animals after 50 days of treatment. luteinizing hormone (LH), follicle-stimulating hormone (FSH), and the level of sex hormone binding globulin (SHBG) also changed in the extract-treated groups. Conclusions Rosa Damascena Mill and Urtica dioica can change testosterone level in the middle-aged animals and also ameliorate andropause symptoms. Mood, muscle strength and cognition would improve following administration of these herbs. The herbal nature of these extracts and their worldwide use in traditional medicine make them more appropriate for human studies and applications.

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“…To exclude the possibility that the behavioral alterations were associated with inability of locomotion activity, we carried out the rotarod test and open-field test, which are used to examine motor coordination and spontaneous locomotion (Moniruzzaman et al 2018;Ramshini et al 2018). It was found that there was no significant difference among the groups in the two tests in terms of time stayed on the rod and traveled distance in the open field (Fig.…”

Section: Nai Exposure Ameliorates Cms-induced Depression-like Behaviorsmentioning

confidence: 99%

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice

Niu

et al. 2022

Environ Sci Pollut Res

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The presence of negative air ions (NAI) is suggested to be a beneficial factor in improving psychological status and used in treating depression as an alternative approach. However, more biological evidence from animal models is needed to ensure the effects of NAI on the mood regulation, through which can facilitate identification of possible underlying mechanisms. In this study, the chronic mild stress (CMS) protocol was used to induce depressive-like behaviors in mice, and the effects of NAI exposure on CMS-induced depression-like behaviors were examined. Thirty-day NAI exposure prevented the CMS-induced depression-like behaviors as shown by the restoration of sucrose preference and reduced immobility time in the tail suspension test. In addition, the elevation of serous corticosterone was present in CMS-treated mice but not existed in those with the NAI exposure. Furthermore, we observed altered ratios of some cytokines secreted by type 1 T helper (Th1) cells and Th2 cells in CMS-treated mice, but it could be restored after NAI exposure. In conclusion, NAI intervention is able to ameliorate CMS-induced depression-like behaviors in mice, and this effect is associated with the alteration of corticosterone and functional rebalance between Th1 and Th2 cells.

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Contribution of CB1Rs in anxiety-related behaviors but not locomotor deficits induced by methamphetamine

Cited by 8 publications

References 28 publications

Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells

Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells

The Effects of Urtica Dioica Root and Rosa Damascena Mill Petal Extracts on Andropause symptoms and Reproductive Characteristics of Middle-age Male Rats

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice

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