Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice

Abstract

The presence of negative air ions (NAI) is suggested to be a beneficial factor in improving psychological status and used in treating depression as an alternative approach. However, more biological evidence from animal models is needed to ensure the effects of NAI on the mood regulation, through which can facilitate identification of possible underlying mechanisms. In this study, the chronic mild stress (CMS) protocol was used to induce depressive-like behaviors in mice, and the effects of NAI exposure on CMS-induced depression-like behaviors were examined. Thirty-day NAI exposure prevented the CMS-induced depression-like behaviors as shown by the restoration of sucrose preference and reduced immobility time in the tail suspension test. In addition, the elevation of serous corticosterone was present in CMS-treated mice but not existed in those with the NAI exposure. Furthermore, we observed altered ratios of some cytokines secreted by type 1 T helper (Th1) cells and Th2 cells in CMS-treated mice, but it could be restored after NAI exposure. In conclusion, NAI intervention is able to ameliorate CMS-induced depression-like behaviors in mice, and this effect is associated with the alteration of corticosterone and functional rebalance between Th1 and Th2 cells.

Biological effects of negative air ions on human health and integrated multiomics to identify biomarkers: a literature review

“… NAIs have antioxidant and anti-inflammatory effects and can promote wound healing. Hu YQ/ 2022 a Six-week-old male C57BL/6 mice were randomly divided into four groups. (1) Control mice, (2) chronic mild stress (CMS)-treated mice, (3) control mice with 4.0 × 10 4 ions/cm 3 NAIs exposure, and (4) CMS-treated mice with 4.0 × 10 4 ions/cm 3 NAIs exposure for 30 days.…”

Association of Dietary Inflammatory Index With Depression and Suicidal Ideation in Older Adult: Results From the National Health and Nutrition Examination Surveys 2005–2018

“…There is research evidence that depression is significantly associated with chronic systemic inflammation (9). Chronic inflammation can mediate a permanent reorganization of inflammatory neurotransmitter pathways, resulting in the transition from acute to chronic pain and promoting depression, anxiety, and sleep disturbances (10)(11)(12). The association between diet and chronic systemic inflammation is quite close, and an inappropriate dietary structure or pattern is a significant source of chronic systemic inflammation in the organism (13).…”