Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage

Ma, Fang; Cang, Yan-qin; Zhao, Bin; Liu, Yuanyuan; Wang, Chaoqing; Liu, Bo; Wu, Tianfu; Song, Yanan; Peng, Ai

doi:10.1093/ndt/gfr789

Cited by 59 publications

(60 citation statements)

References 21 publications

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“…SonoVue, a second-generation ultrasound contrast agent, which consists of stabilized microbubbles of a sulphur hexafluoride with remarkable properties [13], is used in this study. It can pass the capillary bed and show the microcirculation [14]. Besides, SonoVue can enhance the echo contrast of blood flow in tissues and conveniently detect the lesion and surrounding tissue perfusion changes through the real-time dynamic observation of the CEUS [15,16].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia

Shi

Yin

et al. 2014

Diagn Pathol

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BackgroundThis study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person.MethodsA retrospective study of sixty BPH patients (aged 73.5 ± 20.5 years old) and thirty normal controls without prostate diseases (aged 75.3 ± 19.7 years old) who had accepted CEUS detection were performed. Time-intensity curves were obtained for all tests in regions of interest. Images were processed using ACQ software and the following parameters were obtained: arrival time (AT), peak intensity (P), time to peak (TP), area under the curve (AUC), mean transit time (MTT) and extinction time (ET). Differences in inner and outer gland of prostate between BPH and the normal tissue were evaluated.ResultsThere was a clear boundary between the inner and outer gland of BPH prostate. AT, TP, MTT, ET and P in BPH outer gland were significantly higher than the control group. In inner gland, MTT, ET, AUC and P were also significantly higher than the controls. The accurate rate to diagnose BPH using CEUS was 95.6%, and the sensitivity and specificity were 95.0% and 96.7%, respectively.ConclusionsAmong these significantly changed parameters, the increases of MTT, ET and AUC in inner gland and AT, TP in outer gland were most likely related to BPH. These parameters provide an objective visual assessment to diagnosis of BPH.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4852383312229155

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia

Shi

Yin

et al. 2014

Diagn Pathol

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“…This pRCC showed hyper-enhancement by CEUS. The vascularity of renal parenchyma in patients with end-stage renal disease is less than that found in the general population [24,25], which may influence the appearance of renal tumours.…”

Section: Discussionmentioning

confidence: 89%

Papillary renal cell carcinoma and clear cell renal cell carcinoma: Differentiation of distinct histological types with contrast – enhanced ultrasonography

Xue

Lü

Huang

et al. 2015

European Journal of Radiology

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“…Besides serum or urine test, imaging techniques may help to diagnose CKD [23], [24], [25]. Conventional US can provide some effective information to detect ESRD, such as volume reducing, corticomedullary differentiation disappearing, cortical thinning and echogenicity of cortex increased [26], [27], [28].…”

Section: Discussionmentioning

confidence: 99%

Acoustic Radiation Force Impulse Imaging for Noninvasive Evaluation of Renal Parenchyma Elasticity: Preliminary Findings

et al. 2013

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ObjectiveTo evaluate the diagnostic value of acoustic radiation force impulse (ARFI) to test the elasticity of renal parenchyma by measuring the shear wave velocity (SWV) which might be used to detect chronic kidney disease (CKD).Methods327 healthy volunteers and 64 CKD patients were enrolled in the study. The potential influencing factors and measurement reproducibility were evaluated in the healthy volunteers. Correlations between SWV and laboratory tests were analyzed in CKD patients.?Receiver-operating characteristic curve (ROC) analyses were performed to assess the diagnostic performance of ARFI.ResultsThe SWV of healthy volunteers correlated significantly to age (r = −0.22, P<0.001, n = 327) and differed significantly between men and women (2.06±0.48 m/s vs. 2.2±0.52 m/s, P = 0.018, n = 327). However, it did not correlate significantly to height, weight, body mass index, waistline, kidney dimension and the depth for SWV measurement (n = 30). Inter- and intraobserver agreement expressed as intraclass coefficient correlation were 0.64 (95% CI: 0.13 to 0.82, P = 0.011) and 0.6 (95% CI: 0.31 to 0.81, P = 0.001) (n = 40). The mean SWV in healthy volunteers was 2.15±0.51 m/s, while was 1.81±0.43 m/s, 1.79±0.29 m/s, 1.81±0.44 m/s, 1.64±0.55 m/s, and 1.36±0.17 m/s for stage 1, 2, 3, 4 and 5 in CKD patients respectively. The SWV was significantly higher for healthy volunteers compared with each stage in CKD patients. ARFI could not predict the different stages of CKD except stage 5. In CKD patients, SWV correlated to e-GFR (r = 0.3, P = 0.018), to urea nitrogen (r = −0.3, P = 0.016), and to creatinine (r = −0.41, P = 0.001). ROC analyses indicated that the area under the ROC curve was 0.752 (95% CI: 0.704 to 0.797) (P<0.001). The cut-off value for predicting CKD was 1.88 m/s (sensitivity 71.87% and specificity 69.69%).ConclusionARFI may be a potentially useful tool in detecting CKD.

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Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage

Cited by 59 publications

References 21 publications

RETRACTED ARTICLE: Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia

RETRACTED ARTICLE: Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia

Papillary renal cell carcinoma and clear cell renal cell carcinoma: Differentiation of distinct histological types with contrast – enhanced ultrasonography

Acoustic Radiation Force Impulse Imaging for Noninvasive Evaluation of Renal Parenchyma Elasticity: Preliminary Findings

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