Contrast-Enhanced Ultrasound Imaging

Pretorius, Dolores H.; Fines-Dailey, Verlee; Horani, Javine; Nelson, Thomas R.

doi:10.3109/9781420004632-4

Cited by 7 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A microbubble (MB) excited by an ultrasound pressure wave is an instance of a complex nonlinear dynamical system with resonances, several attractors and their basins, multiple bifurcations and chaotic behavior and not “yet fully describable behavior” due to its infinite complexity [1] , [2] , [3] . In spite of the complexity, MBs are used in industrial applications like cleaning [4] , [5] , food production [6] , sonochemistry [7] , [8] , [9] , sonoluminescence [9] , [10] , mixing [11] , [12] , therapeutic [13] , [14] , [15] , [16] and diagnostic [17] , [18] , [19] , [20] ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

Sojahrood

Haghi

Karshafian

et al. 2021

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

Sojahrood

Haghi

Karshafian

et al. 2021

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

“…in the liver, kidney and the myocardium) [38][39][40]. Due the absence of SHs and UHs in tissues response to diagnostic ultrasound [20,[41][42][43]; SH and UH emissions by bubbles allow the detection of blood flow with exceptional contrast enhancement [20,[41][42][43]. Furthermore, SH emissions have lower frequencies and are attenuated less by the tissue.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear dynamics of acoustic bubbles excited by their pressure dependent subharmonic resonance frequency: oversaturation and enhancement of the subharmonic signal

Sojahrood,

Earl,

et al. 2019

Preprint

View full text Add to dashboard Cite

The acoustic bubble is an example of a highly nonlinear system which is the building block of several applications and phenomena ranging from underwater acoustics to sonochemistry and medicine. Nonlinear behavior of bubbles, and most importantly 1 2 order subharmonics (SH), are used to increase the contrast to tissue ratio (CTR) in diagnostic ultrasound (US) and to monitor bubble mediated therapeutic US. It is shown experimentally and numerically that when bubbles are sonicated with their SH resonance frequency (f sh = 2fr where fr is the linear resonance frequency), SHs are generated at the lowest excitation pressure. SHs then increase rapidly with pressure increase and reach an upper limit of the achievable SH signal strength. Numerous studies have investigated the pressure threshold of SH oscillations; however, conditions to enhance the saturation level of SHs has not been investigated. In this paper nonlinear dynamics of bubbles excited by frequencies in the range of fr < f < 2fr is studied for different sizes of bubbles (400nm-8 µm). We show that the SH resonance frequency is pressure dependent and decreases as pressure increases. When a bubble is sonicated with its pressure dependent SH resonance frequency, oscillations undergo a saddle node bifurcation from a P1 or P2 regime to a P2 oscillation regime with higher amplitude. The saddle node bifurcation is concomitant with over saturation of the SH and UH amplitude and eventual enhancement of the upper limit of SH and UH strength (e.g. ≈ 7 dB in UH amplitude). This can increase the CTR and signal to noise ratio in applications. Here, we show that the highest non-destructive SH amplitude occurs when f ≅ 1.5 − 1.8fr

show abstract

“…Therefore, studying the tumor angiogenesis and microvessel density (MVD) can help to assess the prognosis of cancer patients 5-6. Currently, imaging techniques such as CT, MRI, and ultrasound have been widely used in preoperative diagnosis of ovarian tumors 7, 8. Thereinto, ultrasound is a convenient imaging technique.…”

Section: Introductionmentioning

confidence: 99%

Study on the Characteristics of Contrast-Enhanced Ultrasound and Its Utility in Assessing the Microvessel Density in Ovarian Tumors or Tumor-Like Lesions

Wang¹,

Lv²,

Fei³

et al. 2011

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Angiogenesis is a critical factor in tumor growth and metastasis, and microvessel density (MVD) was an important parameter for assessing vessels in tumors. However, radiologic assessment of tumor vascularity is not yet well established. In our study, we aimed at investigating the efficacy of contrast-enhanced ultrasonography (CEUS) in exploring the vascularity of the ovarian tumors or tumor-like lesions to assess the relationship between the parameters of the peak intensity (PI) and area under curve (AUC) on CEUS and MVD in ovarian masses. Compared to the contrast-enhanced ultrasound technique, conventional ultrasound shows limitation in differentiating benign and malignant ovarian tumors. The former is promising in improving the sensitivity of detecting small vessels and blood flow in ovarian tumors. Our results showed clear differences in enhancement patterns between benign and malignant ovary tumors or tumor-like lesions. The PI and AUC in the malignant tumors were significantly higher than those in the benign tumors or tumor-like lesions (p=0.001 and =0.01, respectively). The MVD was 43.1 ± 20.4 in the benign tumors or tumor-like lesions and was 65.3 ± 22.3 in the malignant ones (p= 0.01). In both the benign and malignant groups, the PI and AUC were correlated significantly with the MVD (r=0.595, p = 0.001; r =0.533, p = 0.003, respectively). The PI and AUC in CEUS can reflect the MVD in ovarin tumors. The PI and AUC of the ovarian masses in the contrast transvaginal sonography show significant correlation with the angiogenesis and may help in assessing tumor vascularity in ovarian masses.

show abstract

Contrast-Enhanced Ultrasound Imaging

Cited by 7 publications

References 40 publications

Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

Nonlinear dynamics of acoustic bubbles excited by their pressure dependent subharmonic resonance frequency: oversaturation and enhancement of the subharmonic signal

Study on the Characteristics of Contrast-Enhanced Ultrasound and Its Utility in Assessing the Microvessel Density in Ovarian Tumors or Tumor-Like Lesions

Contact Info

Product

Resources

About