Contrast-enhanced dynamic magnetic resonance imaging of finger joints in osteoarthritis and rheumatoid arthritis: an analysis based on pharmacokinetic modeling

Abstract

DCE-MRI may provide useful information that can help differentiate synovitis in OA from synovitis in RA.

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

“…In clinical imaging and research of RA, the exploitation of the potential of MRI is continuously increasing [20][21][22]. Bone marrow oedema has been identified as a possible precursor to erosions and as an early marker of RA [23].…”

Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T

“…In previous studies, DCE-MRI was suggested for assessment of synovitis [7][8][9][10][11]. The EER or the relative early enhancement rate (RER) [18] are often applied for assessment of inflamed synovium for it enhances rapidly within the first 20-30 s after a bolus injection of intravenous contrast-medium.…”

“…Within the last years, dynamic contrast enhanced MRI (DCE-MRI) with the sequential acquisition of T1-weighted images after intravenous administration of gadolinium-chelates was extensively investigated [7][8][9]. The early enhancement rate (EER) measured between 30 and 60 s has been shown to correlate with disease activity including histological measures of inflammation such as vascularity and perivascular edema [10,11].…”

“…However, the underlying mechanisms include changes of physiological parameters such as a morecompartmental distribution of the contrast-material due to increased capillary permeability and diffusion through differently active synovial layers, as well as sequence dependant effects. Therefore, the newer approaches apply a morecompartment model to the signal intensity-time curves to estimate these pathophysiological changes [8,9].…”

Synovitis maps for the assessment of inflammatory diseases of the hand

“…To perform DCE-MRI of the hand and wrist, improved temporal and spatial resolution is necessary due to the fast enhancement of the synovium and the relatively small anatomical structures. Therefore, rapid 3D sequences with high spatial resolution should be chosen [20,21]. A correlation between the results of DCE-MR and clinical findings such as joint swelling, pain and disease activity scores has been reported [22][23][24].…”