Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

Buchbender, Christian; Scherer, A.; Kröpil, Patric; Körbl, Birthe; Quentin, Michael; Reichelt, D; Lanzman, Rotem S.; Mathys, Christian; Blondin, D.; Bittersohl, Bernd; Zilkens, Christoph; Hofer, Matthias; Wittsack, Hans‐Jörg; Schneider, Matthias; Antoch, Gerald; Ostendorf, Benedikt; Miese, Falk

doi:10.1007/s00256-011-1276-2

Cited by 29 publications

(12 citation statements)

References 45 publications

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“…So far, a few studies have applied dGEMRIC and T2 mapping for the assessment of cartilage changes in healthy control subjects and patients with RA 7 11 15 16. These data, conducted in a small number of subjects, have shown that both techniques are feasible to measure the biochemical properties of cartilage in the finger joints.…”

Section: Introductionmentioning

confidence: 99%

Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis

et al. 2013

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Objectives To investigate the relation between anatomic changes of the synovium, the bone, the bone marrow and the cartilage to biochemical properties of the cartilage in patients with rheumatoid arthritis (RA). Methods 33 patients with RA received 3-T MRI scans of the metacarpophalangeal joints. Two independent methods, (A) the delayed gadolinium enhanced MRI of the cartilage (dGEMRIC, T2-mapping), which was used to assess the biochemical properties of the cartilage; (B) synovitis, osteitis and bone erosions were quantified according to the RA MRI scoring (RAMRIS) method and cartilage thickness (CT), interbone joint space (IBJS, distance between proximal and distal bone surface) and intercartilage joint space (ICJS, distance between proximal and distal cartilage surface) were measured. Results Biochemical changes of the cartilage, corresponding to low dGEMRIC and high T2 values, were more likely to be seen in joints with decreased IBJS and ICJS as well as decreased CT. For instance, dGEMRIC was directly correlated to the IBJS ( p=0.001) and ICJS ( p=0.001), whereas T2 mapping was inversely correlated to IBJS and ICJS (both p=0.017). Moreover, the degree of osteitis, and to some extent synovitis, was correlated to biochemical cartilage changes as measured by dGEMRIC ( p=0.003) or the T2 mapping ( p=0.013). By contrast, bone erosions did not correlate to the degree of biochemical cartilage changes. Discussion These data support the concept that synovitis and osteitis may be two main triggers for cartilage damage. Thus, the actual inflammatory state of a joint, but not so much the degree of bone erosion, appears to influence cartilage properties in RA.

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Section: Introductionmentioning

confidence: 99%

Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis

et al. 2013

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“…Several specialized MRI techniques are available for the detection and quantification of early cartilage damage such as delayed Gadolinium-Enhanced MRI of the Cartilage (dGEMRIC), T2 mapping, T1-sodium MRI, and cartilage volume/thickness measurements. 32,33 With advanced cartilage disease in inflammatory arthritis, chondral loss is seen throughout the articular surface in contradistinction to OA where cartilage damage mainly affects the weightbearing surfaces. In addition, cartilage loss in inflammatory conditions often involves the bare areas of the joint that are located adjacent to the joint capsule.…”

Section: Cartilagementioning

confidence: 99%

Hip Inflammatory Conditions: A Practical Differential Diagnosis Algorithmic Approach in Adults and Children

Jaremko

Teh

Weidekamm

et al. 2019

Semin Musculoskelet Radiol

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The child or adult patient presenting with acute hip pain in the absence of major trauma often presents a difficult diagnostic dilemma, due to the complex anatomy and diversity of pathology at the hip. A correct diagnosis is important because untreated hip inflammatory disease can lead to lifelong morbidity from structural damage at this weightbearing joint. An effective and efficient process of reaching an appropriate diagnosis often requires multiple imaging modalities overseen by careful clinical judgment. This article reviews an algorithmic approach to imaging the acutely painful hip, with attention to uses and limitations of each imaging modality, and it offers details on the key differential diagnoses in adults and children.

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“…Niedrige dGEMRIC Signale korrelieren mit weniger GAG Gehalt des Knorpels [26]. Es konnte gezeigt werden, dass dies auch im Knorpel der MCP Gelenke gesunder dargestellt werden kann [27]. So korreliert das Ausmaß der entzündlichen Veränderungen des RAMRIS (für Synovialitis und Knochenmarködem) deutlich besser mit der Abnahme der Knorpelqualität als der Erosionsscore [28].…”

Section: Innovative Mrt-sequenzenunclassified

Magnetresonanztomografie peripherer Gelenke – up-date 2016

2016

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ZusammenfassungModerne und innovative bildgebende Verfahren spielen heute in der Rheumatologie eine zunehmend wichtige Rolle und werden dabei regelhaft bei Diagnosestellung und Therapiekontrolle eingesetzt. Neben der Sonografie, welche heute die rechte Hand des Rheumatologen darstellt, ist die Magnetresonanz-Tomografie (MRT), auch und gerade peripherer Gelenke, zunehmend in den wissenschaftlichen Fokus gerückt. Sie ist in der Lage hochsensitiv entzündliche artikuläre, periartikuläre und ossäre Veränderungen (wie die Synovialitis oder das Knochenmarködem) zu erkennen und dann darüber hinaus deutlich früher als bspw. das konventionelle Röntgen erosive Gelenkveränderungen ab zu bilden. Neben diesen Vorteilen ist es heute durch standardisierte Scoring-Systeme möglich MRT-Untersuchungen besser zu vergleichen, wobei hierfür erste vereinfachte Scores entwickelt und evaluiert wurden. Durch neue und innovative Sequenzen können frühzeitig Veränderungen des Knorpels erkannt werden. Dynamische MRT-Sequenzen versprechen eine noch genauere Darstellung lokaler Inflammation und sind neben hybriden bildgebenden Verfahren (z. B. PET-MRT oder SPECT-MRT) aktuell Gegenstand intensiver wissenschaftlicher Forschung.

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Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

Abstract: The data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of ΔR1 does not increase the diagnostic value of dGEMRIC.

Cited by 29 publications

References 45 publications

Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis

Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis

Hip Inflammatory Conditions: A Practical Differential Diagnosis Algorithmic Approach in Adults and Children

Magnetresonanztomografie peripherer Gelenke – up-date 2016

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