Continuous positive air pressure improves orthonasal olfactory function of patients with obstructive sleep apnea

Walliczek‐Dworschak, Ute; Cassel, Werner; Mittendorf, Luisa; Pellegrino, Robert; Koehler, Ulrich; Güldner, Christian; Dworschak, Philipp; Hildebrandt, Olaf; Daniel, Hanna; Günzel, Thomas; Teymoortash, Afshin; Hummel, Thomas

doi:10.1016/j.sleep.2017.02.018

Cited by 12 publications

(9 citation statements)

References 37 publications

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“…11,20 Positive airway pressure treatment may improve olfactory dysfunction in patients with OSA through diverse interactions. 5,10 The cholinergic neurotransmitter system is involved in many cognitive functions and sensitive to cerebral hypoxemia. Positive airway pressure through normalizing the synthesis of neurotransmitters may improve cognitive dysfunction in patients with OSA.…”

Section: Discussionmentioning

confidence: 99%

“…Also, a negative correlation between the olfactory function and the severity of OSA has been shown in the literature. 5,7 The goal in the management of OSA is to control the effects of snoring, daytime sleepiness, and neurocognitive impairment, as well as limiting morbidity and mortality associated with long-term cardiovascular disease and motor vehicle accidents. 8 Positive airway pressure (PAP) is accepted as the gold-standard treatment in OSA disease.…”

Section: Introductionmentioning

confidence: 99%

“…9 Previous studies reported that PAP treatment may improve olfaction in patients with OSA through various mechanisms. 5,10,11 The aim of this study is to investigate the contribution of PAP to olfactory function in patients with OSA.…”

Section: Introductionmentioning

confidence: 99%

“…Also, a negative correlation between the olfactory function and the severity of OSA has been shown in the literature. 5,7…”

Section: Introductionmentioning

confidence: 99%

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Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure

et al. 2019

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Previous studies reported that positive airway pressure (PAP) treatment may improve olfaction function in patients with obstructive sleep apnea (OSA) through various mechanisms. Olfactory function before and after PAP treatment is understudied regarding patient group at issue. The aim of this study is to investigate the contribution of PAP to olfactory function in patients with OSA. The study was conducted on 26 patients with OSA (10 females and 16 males, mean age 50.1 [9.3] years) who scheduled for PAP treatment. The Connecticut Chemosensory Clinical Research Center odor test was performed before and 4 months after PAP treatment. Patients were grouped (normal, anosmia, mild hyposmia, moderate hyposmia, and severe hyposmia) with respect to olfactory function by measuring odor test parameters, including threshold determination and identification. The odor test average scores of the patients after 4-month PAP treatment compared to pretreatment scores were increased and the difference was statistically significant ( P = .002). In the apnea hypopnea index groups, statistically significant difference was found in the threshold and discrimination values regarding before PAP treatment ( P = .038, P = .022, respectively). This study revealed that improvement in olfactory thresholds in patients with OSA receiving PAP treatment seems to improve olfactory dysfunction. This provides minimization of OSA consequences, including progressive upper airway inflammation, cognitive impairment, and associated olfactory dysfunction. Resolving the associations between olfactory function and PAP treatment is an important area for future research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Also, a negative correlation between the olfactory function and the severity of OSA has been shown in the literature. 5,7…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure

et al. 2019

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“…It is noteworthy that some previous studies have found threshold tests to be somewhat more sensitive than odor identification tests to olfactory alterations secondary to chronic renal failure, 20 migraine headaches, 21 iron deficiency anemia, 22 and continuous positive airway pressure (CPAP). 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

Impact of antibiotics on smell dysfunction

Wang

Chen

Doty

2018

World j. otorhinolaryngol.-head neck surg.

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ObjectiveViral or bacterial respiratory infections can cause long-lasting olfactory dysfunction. Antibiotic therapy is indicated in severe cases; however, it is unclear whether antibiotic use produces a positive, negative, or null effect on olfactory function. This retrospective study sought to determine whether antibiotic use has an influence on odor identification and detection threshold test scores of patients with smell dysfunction secondary to upper respiratory infections (URIs), lower respiratory infections (LRIs), or rhinosinusitis.MethodsData from a total of 288 patients presenting to the University of Pennsylvania Smell and Taste Center were evaluated.ResultsPatients with a URI etiology who had taken bactericidal antibiotics had lower detection thresholds than did patients who had not taken antibiotics (P < 0.023; analysis of covariance with age and time since infection onset as covariates). Moreover, thresholds were lower for bactericidal antibiotic users than for bacteriostatic antibiotic users with either URI (P = 0.023) or rhinosinusitis (P = 0.028) etiologies. No meaningful influences of antibiotics on the odor identification test scores were evident.ConclusionsThese findings, which need to be confirmed in prospective double-blind studies, suggest that bactericidal antibiotic therapy may be beneficial in mitigating, at least to some degree, chronic decrements in smell sensitivity due to URIs and rhinosinusitis.

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Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions

Dinç

Çayönü

Duyar³

et al. 2019

Sleep Breath

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Continuous positive air pressure improves orthonasal olfactory function of patients with obstructive sleep apnea

Cited by 12 publications

References 37 publications

Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure

Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure

Impact of antibiotics on smell dysfunction

Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions

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