Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure

Kaya, Kerem Sami; Akpınar, Meltem; Türk, Bilge; Seyhun, Nurullah; Cankaya, Mahmut; Coşkun, Berna Uslu

doi:10.1177/0145561319878949

Cited by 3 publications

(2 citation statements)

References 28 publications

(87 reference statements)

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“…Most of our patients, even without having been admitted to an intensive care unit for invasive ventilation, experienced severe acute respiratory failure: it is possible that chemosensory impairment could at least partly be considered as a consequence of the impaired respiratory function [9,10].…”

Section: Discussionmentioning

confidence: 99%

Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life

Meini

Suardi

Busoni

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. This topic is currently arousing great interest, and a growing number of papers are being published. Aim of this study is to investigate the timing of recovery from OD and GD in a reallife population hospitalized for COVID-19. Methods We followed up by a phone interview the first 100 patients discharged a month earlier from three Italian nonintensive care wards. Results All 100 patients were Caucasian, mean age was 65 years, 60% were males. Forty-two patients (mean age 63 years) experienced subjective chemosensory dysfunctions (29 OD and 41 GD): the male/female ratio was 2:1; 83% reported a complete or near complete recovery at follow-up. The recovery rate was not significantly different between males and females. The mean duration of OD and GD was 18 and 16 days, respectively. The mean recovery time from OD or GD resulted significantly longer for females than for males (26 vs 14 days, P = 0.009). Among the 42 symptomatic, the mean age of males was significantly higher than that of females (66 vs 57 years, P = 0.04), while the opposite was observed in the 58 asymptomatic patients (60 vs 73 years, P = 0.0018). Conclusions Recovery from OD or GD was rapid, occurring within 4 weeks in most patients. Chemosensory dysfunctions in women was less frequent, but longer lasting. The value of our study is its focus on a population of hospitalized patients significantly older than those previously described, and the additional data on gender differences.

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Section: Discussionmentioning

confidence: 99%

Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life

Meini

Suardi

Busoni

et al. 2020

Eur Arch Otorhinolaryngol

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“…In OSA, disorders of olfaction have been characterized as well, with the degree of olfactory disturbance correlating with the severity of disease [24]. Furthermore, there is improvement in olfaction after therapy with OSA [25], demonstrating that olfactory pathways maybe early sites of involvement with both diseases.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea and Dementia-Common Gene Associations through Network-Based Identification of Common Driver Genes

Jeong

Chandrakantan

Adler

2021

Genes

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Background: Obstructive Sleep Apnea (OSA) occurs in 7% of the adult population. The relationship between neurodegenerative diseases such as dementia and sleep disorders have long attracted clinical attention; however, no comprehensive data exists elucidating common gene expression between the two diseases. The objective of this study was to (1) demonstrate the practicability and feasibility of utilizing a systems biology approach called network-based identification of common driver genes (NICD) to identify common genomic features between two associated diseases and (2) utilize this approach to identify genes associated with both OSA and dementia. Methods: This study utilized 2 public databases (PCNet, DisGeNET) and a permutation assay in order to identify common genes between two co-morbid but mutually exclusive diseases. These genes were then linked to their mechanistic pathways through Enrichr, producing a list of genes that were common between the two different diseases. Results: 42 common genes were identified between OSA and dementia which were primarily linked to the G-coupled protein receptor (GPCR) and olfactory pathways. No single nucleotide polymorphisms (SNPs) were identified. Conclusions: This study demonstrates the viability of using publicly available databases and permutation assays along with canonical pathway linkage to identify common gene drivers as potential mechanistic targets for comorbid diseases.

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Correlation and agreement of olfactory perception assessed by the Connecticut Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test

Aniteli¹,

Marson²,

Cunha³

et al. 2022

Brazilian Journal of Otorhinolaryngology

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Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure

Cited by 3 publications

References 28 publications

Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life

Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life

Obstructive Sleep Apnea and Dementia-Common Gene Associations through Network-Based Identification of Common Driver Genes

Correlation and agreement of olfactory perception assessed by the Connecticut Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test

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