Contamination status and accumulation features of persistent organochlorines in pet dogs and cats from Japan

Kunisue, Tatsuya; Nakanishi, S; Watanabe, M.; Abé, Takao; Nakatsu, Satoshi; Kawauchi, Sakio; Sano, Akihiko; Horii, Akira; Y, Kano; Tanabe, Shinsuke

doi:10.1016/j.envpol.2004.12.039

Cited by 39 publications

(41 citation statements)

References 33 publications

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“…Our results, however, were much higher than those described in gonadal tissues of domestic dogs in Japan in 2005 (Kunisue et al 2005), although this comparison may not be appropriate, since it has been reported that HCB in dogs is distributed effectively firstly to the lungs, and later to other visceral organs (mainly liver, kidneys and spleen), and afterwards, much more slowly, to fatty tissues and other target tissues, where this pollutant reaches low concentrations (Sundlof et al 1982). On the other hand, the plasma levels of HCB in humans of this study were fully comparable with those described recently in other European countries (Koppen et al 2009;Mari et al 2013).…”

Section: Concentrations Of Ocps In Dog and Human Plasmacontrasting

confidence: 56%

“…Reversely, in samples of canine plasma the situation was radically different, as the median value was 0 ng/g lw, and detection frequency did not exceed 8% for any of these analytes. This had already been described in dogs of Pakistan and Japan (Kunisue et al 2005;Ali et al 2013), and also in Russian wolves (Shore et al 2001), so it has been suggested that canines, unlike many other mammalian species, do not accumulate these pollutants throughout their life, probably because they are equipped with efficient mechanisms of biotransformation and elimination (Kunisue et al 2005). All the evidences set out above, in which the values of most of the contaminants in this group were much higher in humans than in dogs, especially so different pollution profiles between the two species, indicate that the dog is not a good indicator of human exposure to OCPs.…”

Section: Dog Plasmamentioning

confidence: 99%

“…In any case, it has also been suggested that the canines could have the ability to efficiently metabolize PCBs, or at least some congeners (Kunisue et al 2005), since the few studies that have investigated the levels of these pollutants in dogs have also reported a very low level thereof as compared to those commonly found in mammalian species (Shore et al 2001;Kunisue et al 2005;Ali et al 2013).…”

Section: Concentrations Of Pcbs In Dog and Human Plasmamentioning

confidence: 99%

“…Numerous studies have revealed that POPs, individually and in combination, may contribute to the development of severe health problems such as immune suppression, genotoxic effects or cancer and are of public health concern worldwide (WHO 2003;Kortenkamp 2007;Kortenkamp et al 2007Kortenkamp et al , 2011Valeron et al 2009;Lauby-Secretan et al 2013;Jarvis et al 2014). As far as we know, there is no research that has assessed exposure to PAHs in dogs to date, and very few scientific studies have evaluated organochlorine contamination of dogs and cats (Kunisue et al 2005;Storelli et al 2009;Ali et al 2013;Dirtu et al 2013). These studies have indicated that dogs, as occurs with other canines (Georgii et al 1994;Shore et al 2001), accumulated minor amounts of some of these compounds (particularly DDT and its metabolites, and the highly chlorinated biphenyls) than other mammalian species.…”

Section: Introductionmentioning

confidence: 99%

“…These studies have indicated that dogs, as occurs with other canines (Georgii et al 1994;Shore et al 2001), accumulated minor amounts of some of these compounds (particularly DDT and its metabolites, and the highly chlorinated biphenyls) than other mammalian species. Therefore, it has been suggested that the canines may have greater metabolic capacity and elimination of these compounds than other mammalian species (Georgii et al 1994;Kunisue et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Ruiz-Suárez

Rial

Boada

et al. 2015

Journal of Applied Animal Research

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Several studies have shown that pet dogs and cats, since they share the habitat with people, could be good sentinels for human exposure to environmental pollutants. However, some publications have suggested that dogs could efficiently metabolize and eliminate some persistent organic pollutants (POPs), which are accumulated by humans throughout life. For this reason, the role of domestic dogs as sentinels could not be appropriate, at least for certain contaminants. To test this hypothesis, we designed this study in which we determined plasma levels of 56 POPs (11 organochlorine pesticides [OCPs], 18 polychlorinated biphenyls [PCBs] and 27 polycyclic aromatic hydrocarbons) in the plasma of 87 dogs and 100 people from the same area (the Canary Islands, Spain). We detected most of these contaminants in the plasma of both species, although the frequencies of detection, concentrations and profiles were very different from each other, especially for ∑OCPs and ∑PCBs. In light of these results, we can conclude that, although they share the environment, sources of exposure to these pollutants and/or the metabolic capabilities do not seem to be comparable between the two species, so that the dog does not seem to be a good sentinel for human exposure to these contaminants.

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Section: Concentrations Of Ocps In Dog and Human Plasmacontrasting

confidence: 56%

Section: Dog Plasmamentioning

confidence: 99%

Section: Concentrations Of Pcbs In Dog and Human Plasmamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Ruiz-Suárez

Rial

Boada

et al. 2015

Journal of Applied Animal Research

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Dioxin‐like and perfluorinated compounds in pigs in an Indian open waste dumping site: Toxicokinetics and effects on hepatic cytochrome P450 and blood plasma hormones

Watanabe

Kunisue

Lin

et al. 2010

Enviro Toxic and Chemistry

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Dioxins and related compounds (DRCs) and perfluorinated compounds were measured in the livers of pigs (Sus scrofa) collected from an open waste dumping site in South India. Hepatic concentrations of DRCs and perfluorooctanesulfonate (PFOS; up to 200 ng/g wet wt) were significantly higher in male and female pigs, respectively, collected from the dumping site than in those from a reference site. Results suggest that dumping sites are a source of DRCs and PFOS. Hepatic concentrations of DRCs in piglets were higher than in mothers, especially for the congeners with molecular weights in the range of 360 to 400, implying congener-specific maternal transfer of DRCs in swine. Concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans and some non-ortho dioxin-like polychlorinated biphenyls (PCBs) in the liver of pigs were higher than those in the adipose fat and muscle of the same specimens. In addition, the liver-to-adipose concentration ratios for each congener had a significant positive correlation with the levels of hepatic cytochrome P450 (CYP)1A-like protein, suggesting congener-specific and CYP1A-dependent hepatic sequestration of DRCs in the swine. Total hepatic 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (TEQs; 8.9-350 pg/g fat wt) had a significant positive correlation with CYP1A-like protein expression (r=0.56, p=0.012), suggesting the induction of CYP1A by DRCs. However, the total TEQs had a significant negative correlation with CYP4A-like protein (r=-0.49, p=0.029), suggesting repression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-mediated signaling pathway by DRCs. Decreases in plasma total thyroxine (T4), free T4, and immunoglobulin (Ig) G were also found in pigs from the dumping site compared with those from the reference site. This study provides insight into the toxicological impacts of DRCs and perfluorinated compounds in wild animals from open waste dumping sites.

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Pets as Sentinels of Indoor Contamination

Poma

Malarvannan

2019

Pets as Sentinels, Forecasters and Promoters of Human Health

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Historically, domestic and wild animals have been used as sentinels for human exposure to environmental contaminants, providing an early warning system for public health intervention. Since domestic animals, particularly cats and dogs, share their (indoor) environment with humans, they can respond to or be affected by toxic assaults like their owners. Given that, the potential for pets to act as biosentinels of human exposure to environmental contaminants has been explored in many scientific papers. In this chapter, an overview of literature studies of how pets have served as sentinels for human health effects resulting from exposure to several classes of environmental contaminants (such as metals, persistent organic pollutants, flame retardants, and polycyclic aromatic hydrocarbons) is reported and discussed. The possible links among the studies and/or the potential gaps in knowledge and research were also investigated. The presented studies indicated that cats and dogs are exposed to complex mixtures of industrial chemicals. The research outcomes demonstrated how pets well may be serving as sentinels for human health, as they breathe in, ingest, or absorb the same chemicals that are in our (indoor) environments.

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Contamination status and accumulation features of persistent organochlorines in pet dogs and cats from Japan

Cited by 39 publications

References 33 publications

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Dioxin‐like and perfluorinated compounds in pigs in an Indian open waste dumping site: Toxicokinetics and effects on hepatic cytochrome P450 and blood plasma hormones

Pets as Sentinels of Indoor Contamination

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