Contact Dermatitis From Selenium Sulfide Shampoo

Eisenberg, Ben C.

doi:10.1001/archderm.1955.03730310073016

Cited by 8 publications

(3 citation statements)

References 1 publication

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“…Skin irritation with pruritus is the most common side effect. Contact dermatitis confirmed by patch testing has also been reported [71]. Hair discoloration has also been reported, with all cases being reversible within weeks after cessation [68, 72].…”

Section: Adjuvant Therapymentioning

confidence: 99%

Treatment of Tinea Capitis

Alkeswani

Cantrell²,

Elewski

2019

Skin Appendage Disord

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Tinea capitis is a common fungal infection of the hair of the scalp affecting predominately prepubertal children. In the US, griseofulvin has been considered a first-line therapy agent for tinea capitis since the 1960s. However, it has been falling out of favor due to significant treatment failure, high cost, and long duration of treatment. Other antifungal agents have been researched as an alternative to griseofulvin. This paper will review the relevant pharmacologic properties, dosing, cost, efficacy, and adverse events profile for griseofulvin, terbinafine, itraconazole, fluconazole, and some adjuvant therapy options such as selenium sulfide shampoos and topical ketoconazole.

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Section: Adjuvant Therapymentioning

confidence: 99%

Treatment of Tinea Capitis

Alkeswani

Cantrell²,

Elewski

2019

Skin Appendage Disord

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“…Selenium sulfide was first approved for medical use in 1951 [ 14 ]. Since then, it has been widely used for the treatment of seborrheic dermatitis [ 15 ]. As reported by Clark et al, selenium sulfide can control the symptoms associated with dandruff and seborrheic dermatitis at a fraction of the cost of other treatments [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Safety, Efficacy and Attributes of 2.5% Selenium Sulfide Shampoo in the Treatment of Dandruff: A Single-Center Study

Godse,

Godse

2024

Cureus

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Background: Selenium sulfide, available as a shampoo or topical lotion at 1%, or 2.5% concentrations in India, is used as a topical antiseborrheic and antifungal for the treatment of dandruff, seborrheic dermatitis, psoriasis, and tinea versicolor. In the present study, the safety, efficacy, and attributes of 2.5% selenium sulfide shampoo were evaluated in Indian participants with dandruff. Methods: A single-center, single-arm, prospective, investigator-initiated, open-label, post-marketing interventional study was conducted on Indian subjects aged 18-70 years diagnosed with moderate dandruff who were prescribed 2.5% selenium sulfide shampoo every three days for four weeks. The primary endpoints were 1) reduction in total dandruff score assessed using a clinical grading scale for adherent and loose dandruff from baseline to weeks 1, 2, and 4, and 2) incidence of adverse events up to the end of the study. The key secondary endpoints were 1) participants’ perception of shampoo attributes (dandruff reduction, scalp itch, scalp oiliness/greasiness, or fragrance) as assessed by a subjective self-assessment questionnaire post-first wash and at weeks 1, 2, and/or 4; 2) satisfaction with treatment as assessed by investigators and participants using a subjective self-assessment questionnaire at week 4; and 3) reduction in scalp sebum as assessed with a meibometer at weeks 2 and 4. Statistical analysis was performed using the Wilcoxon signed-rank test for continuous variables and the Chi-square test for categorical variables. A p-value of 0.05 was considered to be statistically significant. Results: Of 34 enrolled subjects, 30 completed the four-week study. The mean (standard deviation, SD) age of the study participants was 29.8 (7.87) years, with the majority being females (n=18; 60.0%). Mean (SD) total dandruff score significantly (p=0.001) reduced from a baseline score of 11.5 (2.15) to 7.17 (2.12) at week 1, 4.93 (1.72) at week 2, and 2.5 (1.17) at week 4. All the participants reported dandruff reduction and acceptable fragrance of the shampoo at four weeks. Absence of itching and reduction in oiliness was reported by 73.3% (n=22) of participants at week 4 and by 50.0% (n=15) of participants at week 2, respectively. All participants reported good, very good, or excellent satisfaction with the test shampoo at week 4, whereas the investigators rated the shampoo as very good or excellent in managing dandruff in all participants. At week 4, erythema was reported to be absent in all participants. No adverse events were reported during the study. Conclusions: The 2.5% selenium sulfide shampoo was found to be effective in the management of dandruff and related symptoms like itching, oiliness, and greasiness and had a good safety profile in Indian participants with dandruff.

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“…Daily application of selenium sulfide lotion to the entire cutaneous surface daily for 1 week did not affect blood and urine selenium levels, suggesting that systemic absorption is limited when used topically (23). Cases of allergic contact dermatitis have been documented and verified with patch testing (24). A single‐case report has associated the use of selenium sulfide suspension with suppression of lactation in a 32‐year‐old patient who was applying the medication for tinea versicolor (25).…”

Section: Discussionmentioning

confidence: 99%

Scalp Discoloration from Selenium Sulfide Shampoo: A Case Series and Review of the Literature

Gilbertson

Jarrett

Bayliss

et al. 2011

Pediatric Dermatology

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We describe six patients who developed orange to red-brown scalp discoloration after application of selenium sulfide-containing shampoos. This phenomenon has been described only once previously. In all of the cases, the discoloration resolved shortly after discontinuing the selenium sulfide. Lightly swabbing with isopropyl alcohol facilitated removal of the discoloration. This simple technique serves as a painless diagnostic method, which may prevent unnecessary evaluation with a biopsy.

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Contact Dermatitis From Selenium Sulfide Shampoo

Cited by 8 publications

References 1 publication

Treatment of Tinea Capitis

Treatment of Tinea Capitis

Safety, Efficacy and Attributes of 2.5% Selenium Sulfide Shampoo in the Treatment of Dandruff: A Single-Center Study

Scalp Discoloration from Selenium Sulfide Shampoo: A Case Series and Review of the Literature

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