Consumption of three most widely used analgesics in six European countries

Hudec, Roman; Bozekova, L; Tisonova, J

doi:10.1111/j.1365-2710.2011.01256.x

Cited by 29 publications

(25 citation statements)

References 8 publications

(12 reference statements)

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“…Paracetamol is one of the most frequently used analgesics in Europe , and we showed that the sales of paracetamol have increased in all Nordic countries. The sales of paracetamol have previously been reported to increase from 2003 to 2009 in Denmark, Norway and Finland . We showed that this trend continued through 2015.…”

Section: Discussionsupporting

confidence: 63%

Trends in Use of Paracetamol in the Nordic Countries

Wastesson

Martikainen

Zoëga

et al. 2018

Basic Clin Pharma Tox

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Paracetamol (acetaminophen) is one of the most commonly used analgesics in Europe; however, both the safety and efficacy of paracetamol have recently been questioned. Little is known about cross-national differences in the sales of paracetamol. Using national wholesale statistics and nationwide prescription drug registers, we investigated trends in total and prescribed use of paracetamol in the Nordic countries. The total sales of paracetamol (Anatomical Therapeutic Chemical (ATC) classification system code: N02BE01) measured as defined daily doses (DDD) per 1000 inhabitants/day, and the sales by prescription (users per 1000 inhabitants/year), increased in the Nordic countries from 2000 to 2015. The total sales were highest in Denmark throughout the period, with 65 DDD per 1000 inhabitants/day and lowest in Iceland with 30 DDD per 1000 inhabitants/day in 2015. The cross-national difference in total sales of paracetamol was smaller in 2015 than in 2000. The proportion of paracetamol (DDD per 1000 inhabitants/day) sold by prescription was also highest in Denmark (78%), compared with 75% in Finland, 69% in Sweden, 61% in Norway and 38% in Iceland. Paracetamol by prescription was more common at older ages and among women. Total and prescribed sales of paracetamol have increased in all five Nordic countries over time. Cross-national differences exist, with highest sales per capita in Denmark throughout the period.

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Section: Discussionsupporting

confidence: 63%

Trends in Use of Paracetamol in the Nordic Countries

Wastesson

Martikainen

Zoëga

et al. 2018

Basic Clin Pharma Tox

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“…Sales of analgesics have risen steadily over the past 20 years in Europe [9][10][11][12]. Indeed, in France, analgesics were the most used therapeutic class within primary care settings in 2013 (22% of the market share for all medications) [13].…”

Section: Introductionmentioning

confidence: 99%

Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe

Hider‐Mlynarz

Cavalié

Maison

2018

Brit J Clinical Pharma

129

106

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“…The widespread use of NSAIDs as painkillers has positioned them among the most consumed non-prescription drugs in the market [3,58]. Lipids are characterized by a sharp phase transition temperature that depends on the length of the alkyl chains [55] and the type of polar head groups [56].…”

Section: Discussionmentioning

confidence: 99%

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

Manrique-Moreno

Heinbockel

Suwalsky

et al. 2016

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Non-steroidal anti-inflammatory drugs (NSAIDs) represent an effective pain treatment option and therefore one of the most sold therapeutic agents worldwide. The study of the molecular interactions responsible for their physiological activity, but also for their side effects, is therefore important. This report presents data on the interaction of the most consumed NSAIDs (ibuprofen, naproxen and diclofenac) with one main phospholipid in eukaryotic cells, dimyristoylphosphatidylserine (DMPS). The applied techniques are Fourier-transform infrared spectroscopy (FTIR), with which in transmission the gel to liquid crystalline phase transition of the acyl chains in the absence and presence of the NSAID are monitored, supplemented by differential scanning calorimetry (DSC) data on the phase transition. FTIR in reflection (ATR, attenuated total reflectance) is applied to record the dependence of the interactions of the NSAID with particular functional groups observed in the DMPS spectrum such as the ester carbonyl and phosphate vibrational bands. With Förster resonance energy transfer (FRET) a possible intercalation of the NSAID into the DMPS liposomes and with isothermal titration calorimetry (ITC) the thermodynamics of the interaction are monitored. The data show that the NSAID react in a particular way with this lipid, but in some parameters the three NSAID clearly differ, with which now a clear picture of the interaction processes is possible.

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Consumption of three most widely used analgesics in six European countries

Abstract: Effective therapy needs good prescribing and well-informed prescribers and patients. Our study highlights wide differences in analgesic consumption even among similar European countries. The basis of these differences and their potential clinical impact require further investigation.

Cited by 29 publications

References 8 publications

Trends in Use of Paracetamol in the Nordic Countries

Trends in Use of Paracetamol in the Nordic Countries

Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

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