The objective of this paper was to identify the factors influencing the attitudes of Malaysian farmers in the Cameron Highlands, Pahang, Malaysia, towards Genetically Modified (GM) crops. The survey was conducted between December 2019 and February 2020. Using a simple random sampling method, 348 questionnaires were distributed personally to vegetable farmers in the Cameron Highland by trained enumerators. However, only 176 complete and valid responses were retained for analysis. Descriptive and linear regression analyses were performed using the Statistical Package for Social Sciences (SPSS®) software, Version 24. The results showed that the farmers have high self-efficacy when it comes to farming GM crops, acknowledged the great benefits of GM crops, rated the cost of farming such crops as moderate, and expressed a highly positive attitudes towards GM crops. However, they were also cautious about GM crops in that they perceived them as having moderate risks and a moderate fit with existing farming practices. Additionally, they claimed that government support and market demand were low. Regression analyses indicated that six factors have a significant relationship with attitudes to GM crops, with perceived self-efficacy as the strongest predictor, followed by government support, perceived cost, perceived risks, perceived benefits, and market demand. The results have valuable implications for the future growth of agricultural biotechnology in Malaysia and in other developing countries with a similar culture.