Construction of pH-responsive nanoplatform from stable magnetic nanoparticles for targeted drug delivery and intracellular imaging

Li, Ziqi; Wan, Weimin; Bai, Ziwei; Peng, Bo; Wang, Xi; Cui, Liu; Liu, Zhaoyun; Lin, Kui; Yang, Jian; Hao, Jia; Tian, Fei

doi:10.1016/j.snb.2022.132869

Cited by 15 publications

(3 citation statements)

References 27 publications

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“…Due to the stability of the boronate ester bond between Cur and VB at neutral pH, the DDS exhibited remarkable pH-dependent release, with only 2.5% of Cur released at pH 7.2 and 78% at pH 5.4, demonstrating good selectivity for cancer cells. Moreover, selectivity was also confirmed by cellular uptake studies that showed that the particles can be successfully internalized into HepG2 cells, while no internalization occurs in normal L02 hepatocytes [ 174 ]. Other active targeting techniques used FA as the cancer-cell-targeting agent.…”

Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

et al. 2023

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With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.

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Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

et al. 2023

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“…Guo et al fabricated self-assembled pH-responsive NPs loaded with a TMEM16A inhibitor for the dual-targeting antitumor therapy for lung adenocarcinoma, which demonstrated a significant antitumor activity with dual-targeting therapy using a xenograft mouse model [ 172 ]. Additionally, these polymers are also applicable for the imaging of a wide range of tumors [ 173 ]. The developed system simply accesses the acidic tumor microenvironment or is internalized into endocytic organelles within the tumor endothelial cells, demonstrating a broad tumor specificity across a variety of tumor models [ 174 ].…”

Section: Polymer-based Ddss For Cancer Therapeuticsmentioning

confidence: 99%

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Ding,

Agrawal,

Singh

et al. 2024

Polymers

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Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, the off-target effects of chemotherapy are known to produce side effects and dose-limiting toxicities. Novel delivery platforms based on natural and synthetic polymers with enhanced pharmacokinetic and therapeutic potential for the treatment of cancer have grown tremendously over the past 10 years. Polymers can facilitate selective targeting, enhance and prolong circulation, improve delivery, and provide the controlled release of cargos through various mechanisms, including physical adsorption, chemical conjugation, and/or internal loading. Notably, polymers that are biodegradable, biocompatible, and physicochemically stable are considered to be ideal delivery carriers. This biomimetic and bio-inspired system offers a bright future for effective drug delivery with the potential to overcome the obstacles encountered. This review focuses on the barriers that impact the success of chemotherapy drug delivery as well as the recent developments based on natural and synthetic polymers as platforms for improving drug delivery for treating cancer.

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“…Then, NPMs can be guided with the help of a magnetic field to the tumor and deliver the drug directly to the target. [26][27][28] Huang et al used cisplatin (CDDP)-loaded magnetite-hydroxyapatite nanoparticles for better efficacy in chemotherapy and hyperthermia-based combination therapy against lung cancer. [29] Iglesias et al also used combination therapy with the magnetite and a polymer coating with drug doxorubicin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hyperthermic Potential and Acute Toxicity of PLGA‐PEG/Magnetite Microspheres Loaded with Oxaliplatin Using Mice as a Test System

Pereira¹,

Souza

Pinto

et al. 2023

Macro Reaction Engineering

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Oxaliplatin and modified magnetic nanoparticles (magnetite‐lysine) are inserted into microspheres of previously synthesized poly(lactic acid‐co‐glycolic acid‐b‐ethylene glycol) PLGA‐PEG to evaluate the in vitro hyperthermal potential and the acute toxicity in mice. The used nanoparticles are synthesized by the coprecipitation method, using Fe II and Fe III, and modification with lysine is performed during the synthesis. The drug and the magnetic nanoparticles are inserted into the polymer beads through oil in water (O/W) emulsion. The obtained composites are then characterized by Fourier‐transform infrared (FTIR), Thermogravimetric analysis (TGA), X‐ray Diffraction (XRD), and submitted to magnetic hyperthermia and acute toxicity tests. The hyperthermia tests are conducted according to an experimental design. The magnetite‐lysine nanoparticles reached the temperature for the desired application and are able to raise the temperature by 6 °C at the higher investigated current, time, and concentration conditions. According to the proposed statistical study, only the test time exerted significant positive influence on the observed temperature increase, although synergies between time and concentration and between current and concentration are also significant. In vivo acute toxicity tests are also conducted with swiss mice and revealed that the prepared materials and procedures can be regarded as safe and of low toxicity.

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Construction of pH-responsive nanoplatform from stable magnetic nanoparticles for targeted drug delivery and intracellular imaging

Cited by 15 publications

References 27 publications

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Evaluation of Hyperthermic Potential and Acute Toxicity of PLGA‐PEG/Magnetite Microspheres Loaded with Oxaliplatin Using Mice as a Test System

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