Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

Abstract

With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.

Emerging Applications of Nanotechnology in Healthcare and Medicine

“…Nanotechnology and magnetic drug delivery technology are both innovative approaches in the field of medicine that improve drug delivery and enhance treatment effectiveness. Magnetic drug delivery technology utilizes the application of an external magnetic field to guide drug-loaded nanoparticles to a specific site within the body [ 130 ]. Magnetic nanoparticles can be functionalized with drugs and then injected into the bloodstream.…”

“…This approach allows for more precise drug delivery, minimizing systemic exposure and reducing side effects [ 39 ]. Similarly, by engineering nanoparticles, researchers can create drug carriers with unique properties that are not in conventional drug delivery systems [ 130 , 131 , 132 ]. These nanoparticles can be functionalized and designed specifically to target diseased cells or tissues, improving drug concentration at the desired site and minimizing off-target effects [ 131 ].…”

“…Additionally, nanoparticles can protect the drug payload from degradation, resulting in improved stability and prolonged drug release. Thus, the combination of nanotechnology and magnetic drug delivery technology has shown promise in several areas of medicine [ 130 ]. For example, in cancer treatment, magnetic nanoparticles can be used to deliver chemotherapy drugs directly to tumors, increasing drug concentration at the tumor site and reducing toxicity in healthy tissues.…”

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

“…Magnetic hydroxyapatite composites in drug delivery face challenges arising from complex interaction between different phases, which have an impact on drug stability and release [ 105 , 295 ]. Compared to magnetic hydroxyapatite composites, single-phase magnetic hydroxyapatite is preferred for drug delivery due to its homogeneous structure, which ensures stable drug loading and release properties.…”

Remote Positioning of Spherical Alginate Ferrogels in a Fluid Flow by a Magnetic Field: Experimental and Computer Simulation

“…The creation of smart drug delivery systems with a high level of drug release control at the desired position, at a planned time point, and with the ability to respond either to physiological or external stimuli is in the focus of modern biomedicine [ 1 , 2 , 3 ]. Among the wide variety of targeted delivery systems, the mechanical force-responsive systems are of great interest [ 4 ].…”