Construction of core–shell tecto dendrimers based on supramolecular host–guest assembly for enhanced gene delivery

Chen, Feng; Kong, Lingdan; Wang, Le; Fan, Yu; Shen, Mingwu; Shi, Xiangyang

doi:10.1039/c7tb02585h

Cited by 38 publications

(55 citation statements)

References 44 publications

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“…Due to the non‐covalent interactions the topological structures of the dendrimers can be easily manipulated under certain stimuli. For example, responsive MRI contrast agents and gene delivery carrier were designed to diagnose and treat diseases with good results, showing their great potential in therapeutic applications as drug carriers or biomedical materials …”

Section: Structures Properties and Functions Of Nonlinear Supramolementioning

confidence: 99%

Nonlinear Supramolecular Polymers for Therapeutic Applications

Chen

Kretzschmann

Tian

et al. 2018

Advanced Therapeutics

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An elegant combination of supramolecular polymers exhibiting nonlinear topological structures results in a series of brand new, nonlinear supramolecular polymers. Recently, these polymers have attracted increased attention in various fields due to their diverse and advantageous properties. Especially in therapeutic applications, one can take advantage of their unique chemical, physical, and biological properties such as degradability and stimuli‐responsiveness. Due to the large number of possible module modifications, such polymers have great potential as platforms in disease treatments. In this review, the structures, properties, and functions of different nonlinear supramolecular polymers are summarized. Current therapeutic applications are presented and the prospective design trends are discussed for promoting the development of nonlinear supramolecular polymers.

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Section: Structures Properties and Functions Of Nonlinear Supramolementioning

confidence: 99%

Nonlinear Supramolecular Polymers for Therapeutic Applications

Chen

Kretzschmann

Tian

et al. 2018

Advanced Therapeutics

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“…All these three routes are via a covalent synthetic manner. In view of a non‐covalent approach, the supramolecular “attach‐to” method is often applied to prepare hybrid dendritic polymers, for example, through host‐guest interaction (Chang et al, 2018; F. Chen, Kong, et al, 2017; Song, Xiao, Ouyang, Shen, & Shi, 2020), hydrogen bonding interaction, and metal coordination.…”

Section: Classification and Preparation Of Dendritic Polymersmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

156

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

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“…[ 58 ] The defined architecture and abundant surface amines of PAMAM dendrimers make them become promising non‐viral vectors to electrostatically condense genes for effective gene delivery. [ 59 ] The major advantages of using PAMAM dendrimer/CD nanohybrids for gene therapy lie in the fact that, with the fluorescence properties of CDs, the nanohybrids possess the ability to incorporate dual functions of diagnosis through fluorescence imaging and gene therapy.…”

Section: Biomedical Applications Of Poly(amidoamine) Dendrimer/carbonmentioning

confidence: 99%

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Guo

Shen

Shi

2021

Macromolecular Bioscience

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Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system due to their stable fluorescence property and excellent biocompatibility. The distinctive merits of PAMAM dendrimers and CDs are amenable for them to be constructed as perfect nanohybrids for different biomedical applications, in particular for cancer nanomedicine. Here, the recent advances in the construction of PAMAM dendrimer/CD nanohybrids for diverse biomedical applications, in particular for sensing and cancer theranostics are summarized. Finally, the future perspectives of the PAMAM dendrimer/CD nanohybrids are also briefly discussed.

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Construction of core–shell tecto dendrimers based on supramolecular host–guest assembly for enhanced gene delivery

Abstract: A facile supramolecular assembly approach has been developed to construct core–shell tecto dendrimers with aminated surfaces for enhanced gene delivery.

Cited by 38 publications

References 44 publications

Nonlinear Supramolecular Polymers for Therapeutic Applications

Nonlinear Supramolecular Polymers for Therapeutic Applications

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

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