Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Abstract

Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system due to their stable fluorescence property and excellent biocompatibility. The distinctive merits of PAMAM dendrimers and CDs are amenable for them to be constructed as perfect nanohybrids for different biomedical applications, in particular for cancer nanomedicine. Here, the recent advances in the construction of PAMAM dendrimer/CD nanohybrids for diverse biomedical applications, in particular for sensing and cancer theranostics are summarized. Finally, the future perspectives of the PAMAM dendrimer/CD nanohybrids are also briefly discussed.

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

“…In the progress of dendrimer/carbon‐based nanostructure hybrid carrier systems, dendrimer/CD hybrid platforms have been especially highlighted for the excellent performances in a myriad of biomedical applications such as imaging, sensing and cancer theranostics. [ 431 ] For example, Gopinath and co‐workers prepared a cationic acetylated G5 PAMAM dendrimer, followed by complexing anionic CDs on the periphery via electrostatic interaction. [ 432 ] The fluorescence of the CDs was enhanced by the primary amine groups from the used dendrimer.…”

Engineered Fluorescent Carbon Dots and G4-G6 PAMAM Dendrimer Nanohybrids for Bioimaging and Gene Delivery

“…50−57 Indeed, a review focused on this subject was very recently published, highlighting the application of this type of nanohybrids in biosensing and cancer theranostics. 58 According to this review and to the best of our knowledge too, to date, only a recent work associated CDs with PAMAM dendrimers having in view gene delivery applications. 57 In that study, CDs were prepared from sweet lemon peel and chemically bonded to low generation dendrimers (G1, G2, and G3) to obtain nanohybrids that were promising as targeted non-viral vectors.…”

“…Dendrimers, on the contrary, are monodisperse polymers avoiding this handicap. Nanohybrids of CDs and dendrimers have also been prepared based on CDs from different carbon sources and envisaging distinct applications, most of them in the biosensors and drug delivery fields. − Indeed, a review focused on this subject was very recently published, highlighting the application of this type of nanohybrids in biosensing and cancer theranostics . According to this review and to the best of our knowledge too, to date, only a recent work associated CDs with PAMAM dendrimers having in view gene delivery applications .…”

Hemostatic Electrospun Nanocomposite Containing Poly(lactic acid)/Halloysite Nanotube Functionalized by Poly(amidoamine) Dendrimer for Wound Healing Application: In Vitro and In Vivo Assays

“…Dendrimers are symmetrical 3D monodispersed nanoparticles with functional surface groups surrounding their central core. [ 31,32 ] Multivalence, controllable functional groups on their surface, and the potential to enhance biomaterial interaction with biological environments are some of several advantageous features of dendrimers, especially in the skin. [ 33–35 ] In addition, PAMAM has polar groups on its surface making it more biocompatible than other dendrimer families.…”