Construction of Chitosan‐Based Hydrogel Incorporated with Antimonene Nanosheets for Rapid Capture and Elimination of Bacteria

Abstract

To elaborately construct a novel and efficient photothermal antibacterial nanoplatform is a promising strategy for treating bacterial wound infections. In this work, a composite hydrogel (CS/AM NSs hydrogel) with outstanding antibacterial ability is constructed by incorporating antimonene nanosheets (AM NSs) with extraordinary photothermal properties into the network structure of chitosan (CS). When cultured with bacteria, the CS/AM NSs hydrogel can gather bacteria on the surface through the interaction of CS with the bacterial cell membrane. Subsequently, the intrinsic bactericidal property of CS will kill some of the bacteria. After the introduction of near‐infrared laser, the AM NSs effectively convert light energy into localized heat to eliminate residual bacteria. By virtue of the synergistic action between the capture effect of CS and the photothermal effect of AM NSs, the CS/AM NSs hydrogel shows predominant antibacterial behavior against Escherichia coli and Staphylococcus aureus. In vitro assay and in vivo tests of infected full‐thickness defect wound healing confirm the satisfactory biocompatibility and antibacterial ability. Overall, this work reveals that the CS/AM NSs hydrogel holds great potential as a broad‐spectrum antibacterial wound dressing for treating bacteria‐infected wounds. Additionally, this is the first report of the application of AM NSs in the field of antibacterial treatment.

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

“…Chitosan (CS)/antimonene nanosheets (AMNSs) hydrogels were prepared via a bidirectional freeze-casting approach by Liu’s group. Scanning electron microscope (SEM) images showed that the layered AMNSs were embedded evenly in the framework of the CS hydrogel [ 66 ]. GO lacks stability in a physiological cycle.…”

“…Hence, materials with high photothermal conversion efficiency have gradually caught the attention of researchers. High temperature could cause enzyme inactivation, cell membrane permeability changes [ 66 , 82 ], cytoplasmic outflow [ 66 ], and protein denaturation [ 94 ] ( Figure 1 ). The cell membranes of Escherichia coli became shrunken and blurred after NIR irradiation, and the integrity of the cell membranes was destroyed, indicating that high temperature can destroy bacterial cell membranes [ 95 ].…”

Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

“…[ 1 ] Therefore, there is an urgent need for preparing multifunctional wound dressings to further avoid secondary injuries and accelerate wound healing. [ 2 ] Currently, a variety of wound dressings have been designed to accelerate the reconstruction of skin wound tissue, including membranes, [ 3 ] sponges, [ 4 ] aerogels, [ 5 ] cryogels, [ 6 ] modified gauzes, [ 7 ] and hydrogels. [ 8 ] Among them, hydrogels are widely used because their structures are similar to biological soft tissues.…”

Near‐Infrared Light‐Regulated Drug‐Food Homologous Bioactive Molecules and Photothermal Collaborative Precise Antibacterial Therapy Nanoplatform with Controlled Release Property

“…The relative hemolysis rate of Cu‐GA‐CA‐PDA NRs was determined as described in a previous report with some modifications. [ 34 ] First, the red blood cells (RBCs) were taken from the eyeballs of healthy mice. Then the RBCs were obtained by centrifuging at 8000 rpm for 5 min, and the RBCs were washed with PBS (0.1 m , pH 7.4) for five to six times.…”