Near‐Infrared Light‐Regulated Drug‐Food Homologous Bioactive Molecules and Photothermal Collaborative Precise Antibacterial Therapy Nanoplatform with Controlled Release Property

Sun, Xinyu; Li, Lihua; Zhang, Hui; Dong, Mengna; Wang, Jiao; Jia, Pei; Bu, Tong; Wang, Xin; Wang, Li

doi:10.1002/adhm.202100546

Cited by 25 publications

(19 citation statements)

References 67 publications

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“…The development of controlled release and precise therapy biomedical platform is an effective strategy for combating various diseases, which has attracted extensive attention of a lot of researchers. [ 30,45 ] In this work, the release pattern of CA‐TA‐ZA NSs from CS‐based hydrogels at 25 ± 0.5 °C were evaluated. As shown in Figure 6e,f, when the release equilibrium was reached in CS‐based hydrogels containing different contents (0.2, 0.4, and 0.8 mg) of CA‐TA‐ZA NSs (named as CS0.2, CS0.4, and CS0.8, respectively), the amount of the released CA‐TA‐ZA NSs gradually increased.…”

Section: Resultsmentioning

confidence: 99%

“…This was mainly due to the fact that CA molecules can disturb the fluidity of cell membranes, penetrate cell membranes, and destroy the integrity of cell membranes, resulting in the death of bacteria. [ 30,31 ] As shown in Figure 3b, the SEM images of the bacterial cells showed that the bacterial structures collapsed and shrunk after treating with CA‐TA NEs and CA‐TA‐ZA NSs, leading to the death of the bacteria. However, the morphology of the bacteria treated with TA‐ZA NPs hardly changed, which was consistent with its limited antibacterial activity.…”

Section: Resultsmentioning

confidence: 99%

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Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

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The goal of regenerative wound healing dressings is to restore tissue function back to normal physiological activity and accelerate skin tissue regeneration at wound sites. The optimal strategy to achieve this purpose requires a balance between material functionality, degradation, safety, and tissue regrowth. Herein, for the first time, an ultrasonic-triggered irreversible tending to equilibrium self-assembly and ionic cross-linking codriven strategy is proposed for producing multifunctional cinnamaldehyde-tannic acid-zinc acetate nanospheres (CA-TA-ZA NSs), realizing the fusion of hydrophilic and hydrophobic drug-food small molecules. Moreover, a novel "all-in-one" chitosan (CS)-based hydrogel functionalized by introducing drug-food small molecules self-assembled CA-TA-ZA NSs to the 3D network structures of CS is designed, integrating excellent antibacterial, antioxidant, anti-inflammatory and reducing oxidative stress damage abilities. Additionally, the multifunctional CS-based hydrogel can realize rapid in situ gelation at wound sites and completely cover the irregular wounds. All of these superiorities enable the CS-based hydrogel to clean the wound microenvironment, induce skin tissue remodeling, promote blood vessel repair and hair follicle regeneration, restore the immune system back to normal physiological activity, and accelerate wound healing. Therefore, this study offers a new perspective for the design of advanced functional materials with great application potential in the biomedical field.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

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“…The combined use of these antibacterial mechanisms showed significantly better effects than the use of antibiotics alone and phototherapy (Liu et al, 2018;Xu et al, 2018;Ma et al, 2020). Cu-GA-CA-PDANRs showed the best effects in these studies, leading to almost complete wound healing within 9 days (Sun et al, 2021). For MRSA, PDA/Cu-Cs hydrogel and DNAse-CO@ MPDA also showed excellent bactericidal efficiency and significantly reduced wound injury within 14 days (Xu Q. et al, 2020;Yuan et al, 2021).…”

Section: Synergistic Bactericidal Action Of Pda Nanosystem Mediated Pttmentioning

confidence: 96%

“…The high heat generated by the PDA nanosystem has been shown to be effective in removing bacterial biofilms ( Borzenkov et al, 2020 ). In order to strengthen the antibacterial effects, antibiotic substance is often introduced into the PDA nanosystem, which allows the delivery of antibiotics for selective bacterial killing together with PTT ( Tong et al, 2020 ; Xi et al, 2020 ; Sun et al, 2021 ; Xiao et al, 2021 ). For example, the drug-loaded PDA nanosystem can effectively kill bacteria near a wound and promote wound healing upon irradiation ( Gao et al, 2019 ; Liang et al, 2019 ; Yin et al, 2020 ).…”

Section: Anti-bacterial Effects Of Ptt Mediated By Pda Nanosystemmentioning

confidence: 99%

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

et al. 2022

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Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy (PDT), but PTT can generate heat energy under the excitation of light of specific wavelength, resulting in overheating and damage to target cells or sites. Polydopamine (PDA) has been proved to show plenty of advantages, such as simple preparation, good photothermal conversion effects, high biocompatibility, and easy functionalization and adhesion. Taking these advantages, dopamine is widely used to synthesize the PDA nanosystem with excellent photothermal effects, good biocompatibility, and high drug loading ability, which therefore play more and more important roles for anticancer and antibacterial treatment. PDA nanosystem-mediated PTT has been reported to induce significant tumor inhibition, as well as bacterial killings due to PTT-induced hyperthermia. Moreover, combined with other cancer or bacterial inhibition strategies, PDA nanosystem-mediated PTT can achieve more effective tumor and bacterial inhibitions. In this review, we summarized the progress of preparation methods for the PDA nanosystem, followed by advances of their biological functions and mechanisms for PTT uses, especially in the field of antibacterial treatments. We also provided advances on how to combine PDA nanosystem-mediated PTT with other antibacterial methods for synergistic bacterial killings. Moreover, we further provide some prospects of PDA nanosystem-mediated PTT against intracellular bacteria, which might be helpful to facilitate their future research progress for antibacterial therapy.

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“…In order to obtain a programmed drug release, researchers have developed a number of drug delivery systems that could induce a controllable release of bioactive components by pH, ultrasound or near infrared (NIR) laser [ 37 ]. Among them, the photothermal-controllable release method attracted much attention owing to its potential ability to achieve precise drug release [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Photothermal-Controlled Release of IL-4 in IL-4/PDA-Immobilized Black Titanium Dioxide (TiO2) Nanotubes Surface to Enhance Osseointegration: An In Vivo Study

et al. 2022

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Host immune response has gradually been accepted as a critical factor in achieving successful implant osseointegration. The aim of this study is to create a favorable immune microenvironment by the dominant release of IL-4 during the initial few days after implant insertion to mitigate early inflammatory reactions and facilitate osseointegration. Herein, the B-TNT/PDA/IL-4 substrate was established by immobilizing an interleukin-4 (IL-4)/polydopamine (PDA) coating on a black TiO2 nanotube (B-TNT) surface, achieving on-demand IL-4 release under near infrared (NIR) irradiation. Gene Ontology (GO) enrichment analyses based on high-throughput DNA microarray data revealed that IL-4 addition inhibited osteoclast differentiation and function. Animal experiment results suggested that the B-TNT/PDA/IL-4+Laser substrate induced the least inflammatory, tartrate-resistant acid phosphatase, inducible nitric oxide synthase and the most CD163 positive cells, compared to the Ti group at 7 days post-implantation. In addition, 28 days post-implantation, micro-computed tomography results showed the highest bone volume/total volume, trabecular thickness, trabecular number and the lowest trabecular separation, while Hematoxylin-eosin and Masson-trichrome staining revealed the largest amount of new bone formation for the B-TNT/PDA/IL-4+Laser group. This study revealed the osteoimmunoregulatory function of the novel B-TNT/PDA/IL-4 surface by photothermal release of IL-4 at an early period post-implantation, thus paving a new way for dental implant surface modification.

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Near‐Infrared Light‐Regulated Drug‐Food Homologous Bioactive Molecules and Photothermal Collaborative Precise Antibacterial Therapy Nanoplatform with Controlled Release Property

Cited by 25 publications

References 67 publications

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

Photothermal-Controlled Release of IL-4 in IL-4/PDA-Immobilized Black Titanium Dioxide (TiO2) Nanotubes Surface to Enhance Osseointegration: An In Vivo Study

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