Construction of a quinoline ring via a 3-component reaction in water: crystal structure analysis and H-bonding patterns of a 2-aryl quinoline

Abstract

Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3,3diethoxypropionate in the presence of air oxygen in water. The crystal structure analysis and H-bonding patterns of one compound prepared are presented. † Electronic supplementary information (ESI) available: Experimental procedures, spectral data and copies of NMR for all new compounds. CCDC 864149. For ESI and crystallographic data in CIF or other electronic format see

Microwave Synthesis and Antimicrobial Activity of Some Copper (II), Cobalt (II), Nickel (II) and Chromium (III) Complexes with Schiff Base 2, 6-pyridinedicarboxaldehyde- Thiosemicarbazone

“…The magnetic moment of Co-PDCTC was found to lie in 2.05 BM. Monomeric cobalt complexes have lower magnetic moment values than would be PDCTC 10 15 18 45 60 62 12 16 19 63 64 76 Cu-PDCTC 13 16 20 59 64 68 13 15 20 68 71 80 Co-PDCTC 14 17 21 63 68 72 12 14 18 63 66 72 Ni-PDCTC 16 19 23 72 76 79 11 15 18 57 71 72 Cr-PDCTC 17 20 24 77 80 82 10 16 20 52 76 80 Streptomycin 22 25 29 100 100 100 19 21 25 100 100 100 (Standard) [38][39][40][41][42] .The magnetic moments of Ni (II) complex was observed at 3.73 BM. This value is in the range reported earlier for octahedral complexes 43 .…”

Distant C-H Activation/Functionalization: A New Horizon of Selectivity Beyond Proximity

“…The development of efficient method for their synthesis (113)(114)(115)(116)(117)(118)(119) or selective functionalization at different position is of immense importance (120)(121)(122)(123). Unlike C-2 position where the selectivity is based on inherent reactivity of the C=N or N-adjacent Alternative approach for the quinoline functionalization is installation of N-oxide in the quinoline moiety and its use as the DG.…”

Aldo‐X Bifunctional Building Blocks for the Synthesis of Heterocycles

“…For example, ethyl 3,3‐diethoxypropanoate has often been used as an alternative substance to 1,3‐dicarbonyl compounds in Pechmann condensation and Friedel–Crafts alkylation . However, the C2 position of this compound is able to act as a nucleophilic site, which cooperates with the aldo‐group to make another type of bifunctional building block . Because the reactivity of the acid and ester groups are not involved in the established reactions, in these cases, these compounds cannot be considered as AXB3 s.…”