Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds

Wang, Xin; Sun, Xinyu; Bu, Tong; Wang, Qinzhi; Zhang, Hui; Jia, Pei; Li, Longwen; Wang, Li

doi:10.1016/j.actbio.2021.08.022

Cited by 59 publications

(44 citation statements)

References 42 publications

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“…Promisingly, metal–organic frameworks (MOFs) containing active metal cation centers (e.g., Fe 3+ , Co 3+ , etc. ), such as MIL-100 and ZIF-67, have been explored as promising catalysts for CDT, which can kill bacteria directly by slowly releasing or reacting with H 2 O 2 to generate reactive oxygen species (ROS). − However, single nanomaterials still suffer from a relatively low ROS yield and demand for high concentrations of hydrogen peroxide.…”

Section: Introductionmentioning

confidence: 99%

Growth of Cu₂O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Zhao

Hou

et al. 2022

Inorg. Chem.

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Two-dimensional (2D) metal–organic framework (MOF) nanosheets have been demonstrated to be promising templates for the growth of various kinds of nanomaterials on their surfaces to construct novel 2D composites, thus realizing enhanced performance in various applications. Herein, we report the growth of Cu2O nanoparticles on 2D Zr–ferrocene (Zr-Fc)–MOF (Zr-Fc-MOF) nanosheets to prepare 2D composites for near-infrared (NIR) photothermally enhanced chemodynamic antibacterial therapy. The uniform Zr-Fc-MOF nanosheets are synthesized using the solvothermal method, followed by ultrasound sonication, and Cu2O nanoparticles are then deposited on its surface to obtain the Cu2O-decorated Zr-Fc-MOF (denoted as Cu2O/Zr-Fc-MOF) 2D composite. Promisingly, the Cu2O/Zr-Fc-MOF composite shows higher chemodynamic activity for producing ·OH via Fenton-like reaction than that of the pristine Zr-Fc-MOF nanosheets. More importantly, the chemodynamic activity of the Cu2O/Zr-Fc-MOF composite can be further enhanced by the photothermal effect though NIR laser (808 nm) irradiation. Thus, the Cu2O/Zr-Fc-MOF composite can be used as an efficient nanoagent for photothermally enhanced chemodynamic antibacterial therapy.

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Section: Introductionmentioning

confidence: 99%

Growth of Cu₂O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Zhao

Hou

et al. 2022

Inorg. Chem.

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“…The photothermal nanoagents can absorb the NIR and convert the optical energy into heat, which then initiates the cell membrane breakage and protein denaturation in bacteria, finally leading to their thermal ablation [102][103][104]. Based on this, NIR-responsive nanozymes, such as Au nanoplates [26], Au@Pt nanodots [32], Au NRs/CeO 2 hybrid [91], rough carbon/Fe 3 O 4 nanohybrids [102], cationic chitosan@RuO 2 hybrid [105], MoS 2 nanozymes [43,82,106], N-doped carbon nanozyme [55], PEG@Zr-Fc MOF hydrogel [107], and Fe-and Cu-N-C SAzymes [61,63,64], have been developed. Under the NIR laser irradiation, these NIR-active nanozymes can not only produce local photothermal effect, but more importantly the elevated temperature certainly accelerates catalytic reaction rate, thereby realizing the enhanced synergic CDT and PTT for effectively treating drug-resistant bacterial infections.…”

Section: Nir Stimulationmentioning

confidence: 99%

Efficient nanozyme engineering for antibacterial therapy

et al. 2022

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Antimicrobial resistance (AMR) has posed a huge threat to human health. It is urgent to explore efficient ways to suppress the spread of AMR. Antibacterial nanozymes has become one of the powerful weapons to combat AMR due to their enzyme-like catalytic activity with a broad-spectrum antibacterial performance. However, the inherent low catalytic activity of nanozymes limits their expansion into antibacterial applications. In this regard, a variety of advanced chemical design strategies have been developed to improve the antimicrobial activity of nanozymes. In this review, we have summarized the recent progress of advanced strategies to engineering efficient nanozymes for fighting against AMR, which can be mainly classified into catalytic activity improvement, external stimuli, bacterial affinity enhancement, and multifunctional platform construction according to the basic principles of engineering efficient nanocatalysts and the mechanism of nanozyme catalysis. Moreover, the deep insights into the effects of these enhancing strategies on the nanozyme structures and properties are highlighted. Finally, current challenges and future perspectives of antibacterial nanozymes are discussed for their future clinical potential.

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“…PEG derivatives can be obtained by replacing hydroxyl groups with specific functional groups. [ 58 ] When it is substituted with different end groups, the properties of the molecule have different uses and can link drugs with different drug molecules. Multiple PEG derivatives can be derived from various spatial structures, including straight chain, Y‐shaped, U‐branched, multiarmed, etc., to achieve simultaneous binding to multiple target molecules.…”

Section: Polymeric Micelles For Synthesis Of Responsive Hydrogels In ...mentioning

confidence: 99%

Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

Zhu

et al. 2022

Advanced Materials

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Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds

Cited by 59 publications

References 42 publications

Growth of Cu₂O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Growth of Cu₂O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Efficient nanozyme engineering for antibacterial therapy

Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

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Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds

Cited by 59 publications

References 42 publications

Growth of Cu2O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Growth of Cu2O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Efficient nanozyme engineering for antibacterial therapy

Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

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Growth of Cu₂O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Growth of Cu₂O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy