Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

Zhu, Jia‐Qi; Wu, Han; Li, Zhenli; Xu, Xin‐Fei; Xing, Hao; Wang, Mingda; Jia, Hang‐Dong; Liang, Lei; Li, Chao; Yang, Tian; Wang, Yuguang; Shen, Feng; Huang, Dongsheng; Yang, Tian

doi:10.1002/adma.202201651

Cited by 33 publications

(8 citation statements)

References 232 publications

(292 reference statements)

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“…Many ROS-responsive hydrogels that release therapeutics into the tumor microenvironment (TME) in a controlled manner that contains abundant ROS [ 33 , 34 ]. The F/A@P hydrogel, as an alkyl-loaded platform, releases abundant alkyl free radicals in the tumor microenvironment after thermal triggering to resist tumors.…”

Section: Resultsmentioning

confidence: 99%

Injectable versatile liquid-solid transformation implants alliance checkpoint blockade for magnetothermal dynamic-immunotherapy

Wang

Deng

Cao

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Injectable versatile liquid-solid transformation implants alliance checkpoint blockade for magnetothermal dynamic-immunotherapy

Wang

Deng

Cao

et al. 2022

Materials Today Bio

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“…Nanoparticles are a well-studied system for drug transport, especially for anticancer agents with a high therapeutic impact [263][264][265][266][267]. In the case of curcumin, nanoformulations can significantly increase its stability and physiological concentration and thereby its anticancer effect [158].…”

Section: Future Directionmentioning

confidence: 99%

Therapeutic potential and limitations of curcumin as antimetastatic agent

Dytrych¹,

Kejík²,

Hajduch³

et al. 2023

Biomedicine & Pharmacotherapy

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“…Hydrogels are soft materials with a three-dimensional network structure formed by chemical or physical cross-linking of monomers/polymers. − It can respond to external stimuli (light, temperature, pH, etc.) by adjusting the cross-linking mode of hydrogels and types of monomer/polymers. − Therefore, hydrogels show great application potential in the field of actuators. At present, hydrogel actuators can be divided into bilayer hydrogel actuators, gradient hydrogel actuators, patterned hydrogel actuators, and directional hydrogel actuators according to their structures.…”

Section: Introductionmentioning

confidence: 99%

Synchronous Ultraviolet Polymerization Strategy to Improve the Interfacial Toughness of Bilayer Hydrogel Actuators

Tang

Liu

et al. 2023

Macromolecules

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Bilayer hydrogel actuators are of great interest in mechanical valves, soft robots, and bionic devices benefiting from their flexibility and adaptability to actuate in different environments. They respond rapidly to external stimuli through differential deformation of the internal structure to achieve the actuation effect. However, the bilayer hydrogel is prone to delamination due to the low interfacial toughness of the two gel layers, thus they exhibit poor actuating performances. In this work, a synchronous ultraviolet (UV) polymerization strategy was proposed to enhance the interfacial toughness of bilayer hydrogel actuators. Based on the synchronous UV polymerization strategy, a gelatin/poly(N-hydroxyethyl acrylamide)–poly(N-isopropyl acrylamide-co-N-hydroxyethyl acrylamide) [gelatin/PHEAA–P(NIPAM-co-HEAA)] bilayer hydrogel actuator with gelatin/PHEAA functional layer and P(NIPAM-co-HEAA) actuating layer was prepared. The obtained bilayer hydrogel showed a maximum interfacial toughness of 508.11 ± 45.62 J/m2, which was attributed to the covalent bonding and topological entanglement of polymer chains at the gel–gel interface induced by the permeation–polymerization step. In addition, the copolymerization of NIPAM with the hydrophilic monomer N-hydroxyethyl acrylamide (HEAA) increased the lower critical solution temperature of the bilayer hydrogel actuator, which allowed the actuator to exhibit stable actuating ability at 90 °C and to be used as a bionic gripper for high-temperature pickup. Overall, a synchronous UV polymerization strategy was presented. It simplified the fabrication of bilayer hydrogel actuators and enhanced the interaction between bilayer hydrogels by forming strong covalent bonding and local topological entanglement structure at the hydrogel interface, which provided a new idea for preparing bilayer hydrogel actuators with high interfacial toughness.

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Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

Abstract: Figure 2. Summary of the names, chemical structures, and properties of some typical stimuli-responsive compounds.

Cited by 33 publications

References 232 publications

Injectable versatile liquid-solid transformation implants alliance checkpoint blockade for magnetothermal dynamic-immunotherapy

Injectable versatile liquid-solid transformation implants alliance checkpoint blockade for magnetothermal dynamic-immunotherapy

Therapeutic potential and limitations of curcumin as antimetastatic agent

Synchronous Ultraviolet Polymerization Strategy to Improve the Interfacial Toughness of Bilayer Hydrogel Actuators

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