Constructing mesoporous silica-grown reduced graphene oxide nanoparticles for photothermal-chemotherapy

Guo, Dongxue; Yang, Huailin; Chen, Li

doi:10.1016/j.micromeso.2019.109608

Cited by 14 publications

(5 citation statements)

References 44 publications

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“…The size, morphology, and elemental analysis of nanocomposites were evaluated by TEM. As shown in Figure 1 A, MS-rGO, MS-rGO-FA, and ICG@MS-rGO-FA nanocomposites formed a uniform sphere shape, whereas rGO nanosheet showed a transparent single or double nanosheet structure due to the spontaneous aggregation of rGO [ 44 ]. The average diameters of the MS-rGO, MS-rGO-FA, and ICG@MS-rGO-FA nanocomposites were approximately 165.7 ± 7.2, 175.5 ± 8.5, and 191.7 ± 9.2 nm, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the MS-rGO exhibited a large surface area (283.05 m 2 /g), pore volume (1.33 cm 3 /g), and pore size (3.8 nm). The N 2 adsorption-desorption isotherm curve indicated that the MS-rGO nanocomposites were composed of well-defined mesoporous structures and small pore size distributions [ 44 ]. The surface charge and chemical construction of ICG@MS-rGO-FA nanocomposites were confirmed by zeta potential, FT-IR, and UV-vis spectroscopy.…”

Section: Resultsmentioning

confidence: 99%

“…MS-rGO was synthesized according to a previously reported method with minor modifications [ 44 ]. After ultrasonicating a GO solution (50 mL) for 30 min, CTAB (0.5 g) and NaOH (20 mg) were sequentially added and vigorously stirred at 40 °C for 1 h. To form a mesoporous structure on a GO surface, 250 μL of TEOS was added dropwise and subsequently reacted 40 °C for 8 h. The mesoporous silica-coated GO (MS-GO) was washed by centrifugation (14,000 rpm, 10 min) and subsequently washed several times with ethanol (EtOH) and deionized water (DW).…”

Section: Methodsmentioning

confidence: 99%

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Near-Infrared Light-Triggered Generation of Reactive Oxygen Species and Induction of Local Hyperthermia from Indocyanine Green Encapsulated Mesoporous Silica-Coated Graphene Oxide for Colorectal Cancer Therapy

et al. 2022

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Near-infrared (NIR) light-mediated photothermal therapy (PTT) and photodynamic therapy (PDT) have widely been used for cancer treatment applications. However, a number of limitations (e.g., low NIR absorption capacity of photothermal agents, insufficient loading efficiency of photosensitive molecules) have hindered the widespread use of NIR-mediated cancer therapy. Therefore, we developed a mesoporous silica-coated reduced graphene oxide (rGO) nanocomposite that could provide a high encapsulation rate of indocyanine green (ICG) and enhance PTT/PDT efficiency in vitro and in vivo. The ICG-encapsulated nanocomposite not only enhances the photothermal effect but also generates a large number of tumor toxic reactive oxygen species (ROS). By conjugation of polyethylene glycol (PEG) with folic acid (FA) as a tumor targeting moiety, we confirmed that ICG-encapsulated mesoporous silica (MS)-coated rGO nanocomposite (ICG@MS-rGO-FA) exhibited high colloidal stability and intracellular uptake in folate receptor-expressing CT-26 colorectal cancer cells. Upon NIR laser irradiation, this ICG@MS-rGO-FA nanocomposite induced the apoptosis of only CT-26 cells via enhanced PTT and PDT effects without any damage to normal cells. Furthermore, the ICG@MS-rGO-FA nanocomposite revealed satisfactory tumor targeting and biocompatibility in CT-26 tumor-bearing mice, thereby enhancing the therapeutic effects of PTT and PDT in vivo. Therefore, this tumor-targeted ICG@MS-rGO-FA nanocomposite shows a great potential for phototherapy applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Near-Infrared Light-Triggered Generation of Reactive Oxygen Species and Induction of Local Hyperthermia from Indocyanine Green Encapsulated Mesoporous Silica-Coated Graphene Oxide for Colorectal Cancer Therapy

et al. 2022

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“…Finally, via non-covalent bonding, DOX was loaded to the nanocarrier system. It was reported that the DOX release was initiated only by an acidic medium and when subjected to light radiation, the nanoplatform exhibited improved as well as combined photothermal and chemotherapeutic effects [ 193 ]. Another work based on GO was done by Liu et al in which, GO was PEGylated and then loaded with a 2-photon compound (BL4) and photosensitizer (PPa) simultaneously, for the combined photothermal and photodynamic therapies.…”

Section: The Necessity Of Drug Delivery Applicationsmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

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“…Therefore, it is of great urgency to develop a high effective and relatively affordable method for the treatment of prostate cancer, especially late-stage prostate cancer. Nowadays, with some novel therapeutic methods such as gene therapy, photodynamic therapy (PDT), and photothermal therapy (PTT) etc., emerging, the combination of two or more treatments has become a promising strategy to improve the therapeutic efficacy of chemotherapy (Cheng et al, 2017a;Guo et al, 2019). Due to the noninvasive, controllable and highly selective characteristics for cancer treatment, PTT has attracted wide attention for the past few decades (Yang et al, 2018;Cheng et al, 2019;Wang et al, 2019a).…”

Section: Introductionmentioning

confidence: 99%

Zinc Ion-Stabilized Aptamer-Targeted Black Phosphorus Nanosheets for Enhanced Photothermal/Chemotherapy Against Prostate Cancer

Gao

Teng

Zhang

et al. 2020

Front. Bioeng. Biotechnol.

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Prostate cancer is the second most common malignancy among men worldwide. However, conventional chemotherapy, such as taxane therapy, fails to exhibit efficient treatment for almost half of the patients. In this study, a nano-drug delivery system based on black phosphorus nanosheets (BP NSs) was developed, which was then employed as a multifunctional nanoplatform for targeted combinational chemo-photothermal therapy against prostate cancer. Zinc ion (Zn 2+), which has been proven to be able to inhibit prostate cancer cell proliferation, was also introduced into this system. Zn 2+ coordination could not only enhance the therapeutic effect of combined chemophotothermal therapy, but also improve the intrinsic instability of BP NSs through the stabilization of its lone pair electrons. The in vivo study showed the outstanding performance of this system in targeted photothermal/chemotherapy of prostate cancer without side effect to normal organs.

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Constructing mesoporous silica-grown reduced graphene oxide nanoparticles for photothermal-chemotherapy

Cited by 14 publications

References 44 publications

Near-Infrared Light-Triggered Generation of Reactive Oxygen Species and Induction of Local Hyperthermia from Indocyanine Green Encapsulated Mesoporous Silica-Coated Graphene Oxide for Colorectal Cancer Therapy

Near-Infrared Light-Triggered Generation of Reactive Oxygen Species and Induction of Local Hyperthermia from Indocyanine Green Encapsulated Mesoporous Silica-Coated Graphene Oxide for Colorectal Cancer Therapy

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Zinc Ion-Stabilized Aptamer-Targeted Black Phosphorus Nanosheets for Enhanced Photothermal/Chemotherapy Against Prostate Cancer

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