Constitutive nitric oxide synthase activity is required to trigger ischemic tolerance in mouse retina

Zhu, Yanli; Ohlemiller, Kevin K.; McMahan, Belinda K.; Park, Tae Sung; Gidday, Jeffrey M.

doi:10.1016/j.exer.2005.06.005

Cited by 25 publications

(14 citation statements)

References 38 publications

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“…Models of protective preconditioning have been used well to increase our understanding of innate protective stress responses in retina (Roth et al 1998; Li et al 2001; Grimm et al 2002, 2004, 2005, 2006; Li et al 2003; Zhu et al 2006, 2007, 2008; Chollangi et al 2009; Thiersch et al 2009; Ueki et al 2009; Gidday 2010; Grimm and Willmann 2012; Zhu et al 2012; McLaughlin and Gidday 2013); such approaches are revealing several exciting potential therapeutic targets. In the case of exercise, though, it may be that this form of preconditioning, which is accessible to the majority of the population, is itself a therapeutic intervention.…”

Section: 4 Discussionmentioning

confidence: 99%

Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns

Chrenek

Sellers

Lawson

et al. 2015

Retinal Degenerative Diseases

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To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities.

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Section: 4 Discussionmentioning

confidence: 99%

Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns

Chrenek

Sellers

Lawson

et al. 2015

Retinal Degenerative Diseases

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“…That does not appear to be the case. B6 mice expressing normal activity of endothelial and neuronal NOS show ischemic preconditioning protection against retinal and cerebral ischemia (Atochin et al, 2003;Zhu et al, 2006), while knockout mice for these enzymes on the same background do not. The apparent presence of high levels of HIF-1a under normal conditions in B6 cochlear cells suggests either an adaptive process (i.e., the system is always tolerant to hypoxia) or a maladaptive process (the system cannot dynamically adjust to oxygen levels).…”

Section: Genetic Modulation Of Hypoxic Preconditioningmentioning

confidence: 98%

Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice

et al. 2007

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“…Eight rats were selected as the normal control group and fed with ordinary diet. Thirty-two overnight fasted rats were injected with STZ intraperitoneally [7] . After ten days, these rats showed the plasma glucose level above 300 mg/dL and were classified as diabetic.…”

Section: Sample Preparationmentioning

confidence: 99%

Microscopic hyperspectral imaging studies of normal and diabetic retina of rats

Xue

Zhang

et al. 2008

SCI CHINA SER C

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A microscopic hyperspectral imager was developed based on the microscopic technology and the spectral imaging technology. Some microscopic hyperspectral images of retina sections of the normal, the diabetic, and the treated rats were collected by the new imager. Single-band images and pseudo-color images of each group were obtained and the typical transmittance spectrums were extracted. The results showed that the transmittance of outer nuclear layer cells of the diabetic group was generally higher than that of the normal. A small absorption peak appeared near the 180th band in the spectrum of the diabetic group and this peak weakened or disappeared in the spectrum of the treated group. Our findings indicate that the microscopic hyperspectral images include wealthy information of retina sections which is helpful for the ophthalmologist to reveal the pathogenesis of diabetic retinopathy and explore the therapeutic effect of drugs.

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Constitutive nitric oxide synthase activity is required to trigger ischemic tolerance in mouse retina

Cited by 25 publications

References 38 publications

Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns

Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns

Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice

Microscopic hyperspectral imaging studies of normal and diabetic retina of rats

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